Development of microfluidic droplet shooter for ultrahigh-sensitive mass spectrometry

Yutaka Kazoe, Yusuke Shimizu, Yasushi Terui, Kyojiro Morikawa, Kazuma Mawatari, Takehiko Kitamori

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Here we proposed and developed a microfluidic device to continuously shoot pL droplets toward controlled direction at kHz, and verified a novel sample injection interface with mass spectrometry (MS). Utilizing microscale laminar gas flows of 10 m/s enabled formation and shooting of uniform droplets and accurate trajectory control. On the contrary to a few percent sample injection rate by conventional electrospray ionization (ESI), the proposed microdroplet shooter can achieve 100% injection for ultrahigh sensitive MS detection. This study will open a new horizon for separation analysis, especially proteins and peptides which are important in state-of-the-art biological researches and medical diagnosis.

Original languageEnglish
Title of host publication22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
PublisherChemical and Biological Microsystems Society
Pages989-990
Number of pages2
ISBN (Electronic)9781510897571
Publication statusPublished - 2018 Jan 1
Event22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 - Kaohsiung, Taiwan, Province of China
Duration: 2018 Nov 112018 Nov 15

Publication series

Name22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
Volume2

Conference

Conference22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
CountryTaiwan, Province of China
CityKaohsiung
Period18/11/1118/11/15

Keywords

  • Droplet
  • Gas flow
  • Mass spectrometry
  • Microfluidics

ASJC Scopus subject areas

  • Chemistry(all)
  • Bioengineering
  • Chemical Engineering (miscellaneous)
  • Control and Systems Engineering

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  • Cite this

    Kazoe, Y., Shimizu, Y., Terui, Y., Morikawa, K., Mawatari, K., & Kitamori, T. (2018). Development of microfluidic droplet shooter for ultrahigh-sensitive mass spectrometry. In 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 (pp. 989-990). (22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018; Vol. 2). Chemical and Biological Microsystems Society.