Development of necrotizing myopathy following interstitial lung disease with anti-signal recognition particle antibody

Tatsuya Kusumoto, Satoshi Okamori, Keita Masuzawa, Takanori Asakura, Naoshi Nishina, Shotaro Chubachi, Katsuhiko Naoki, Koichi Fukunaga, Tomoko Betsuyaku

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A 72-year-old man was admitted due to dyspnea on exertion with interstitial shadows and elevated serum creatinine kinase (CK). Despite a close examination, which included magnetic resonance imaging (MRI), we could not diagnose myopathy. Prednisolone was administered and gradually tapered. One year later, anti-signal recognition particle (SRP) antibody was confirmed and he was re-admitted for hypoxemia with elevated CK. MRI revealed muscle edema and a histopathological examination of a muscle biopsy specimen showed necrotizing myopathy. Prednisolone, cyclosporine, and intravenous immunoglobulin were administered. Physicians should carefully monitor muscle symptoms and serum CK levels in cases of interstitial lung disease with anti-SRP antibodies.

Original languageEnglish
Pages (from-to)2045-2049
Number of pages5
JournalInternal Medicine
Issue number14
Publication statusPublished - 2018 Jan 1



  • Anti-signal recognition particle antibody
  • Anti-SRP antibody
  • ILD
  • Interstitial lung disease
  • Necrotizing myopathy

ASJC Scopus subject areas

  • Internal Medicine

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