Development of simple firefly luciferin analogs emitting blue, green, red, and near-infrared biological window light

Satoshi Iwano, Rika Obata, Chihiro Miura, Masahiro Kiyama, Kazutoshi Hama, Mitsuhiro Nakamura, Yoshiharu Amano, Satoshi Kojima, Takashi Hirano, Shojiro Maki, Haruki Niwa

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57 Citations (Scopus)

Abstract

Simple firefly luciferin analogs emitting blue, green, and red light were developed. The longest emission maximum was observed at 675 nm, which belongs to the NIR biological window (650-900 nm), useful for deep site bioimaging of living animals. The analogs showed a slow rise of emission intensity compared with the rapid emission of natural luciferin. The light emission of the adenylated analogs was strongly enhanced compared with those of analogs themselves.

Original languageEnglish
Pages (from-to)3847-3856
Number of pages10
JournalTetrahedron
Volume69
Issue number19
DOIs
Publication statusPublished - 2013 May 13

Keywords

  • Biological window
  • Bioluminescence
  • Firefly
  • Luciferin analog
  • Near-infrared

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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    Iwano, S., Obata, R., Miura, C., Kiyama, M., Hama, K., Nakamura, M., Amano, Y., Kojima, S., Hirano, T., Maki, S., & Niwa, H. (2013). Development of simple firefly luciferin analogs emitting blue, green, red, and near-infrared biological window light. Tetrahedron, 69(19), 3847-3856. https://doi.org/10.1016/j.tet.2013.03.050