Development of simple firefly luciferin analogs emitting blue, green, red, and near-infrared biological window light

Satoshi Iwano; Rika Obata; Chihiro Miura; Masahiro Kiyama; Kazutoshi Hama; Mitsuhiro Nakamura; Yoshiharu Amano; Satoshi Kojima; Takashi Hirano; Shojiro Maki; Haruki Niwa

doi:10.1016/j.tet.2013.03.050

Development of simple firefly luciferin analogs emitting blue, green, red, and near-infrared biological window light

Satoshi Iwano, Rika Obata, Chihiro Miura, Masahiro Kiyama, Kazutoshi Hama, Mitsuhiro Nakamura, Yoshiharu Amano, Satoshi Kojima, Takashi Hirano, Shojiro Maki, Haruki Niwa

Department of Humanities and Social Sciences

Research output: Contribution to journal › Article › peer-review

59 Citations (Scopus)

Abstract

Simple firefly luciferin analogs emitting blue, green, and red light were developed. The longest emission maximum was observed at 675 nm, which belongs to the NIR biological window (650-900 nm), useful for deep site bioimaging of living animals. The analogs showed a slow rise of emission intensity compared with the rapid emission of natural luciferin. The light emission of the adenylated analogs was strongly enhanced compared with those of analogs themselves.

Original language	English
Pages (from-to)	3847-3856
Number of pages	10
Journal	Tetrahedron
Volume	69
Issue number	19
DOIs	https://doi.org/10.1016/j.tet.2013.03.050
Publication status	Published - 2013 May 13

Keywords

Biological window
Bioluminescence
Firefly
Luciferin analog
Near-infrared

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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Development of simple firefly luciferin analogs emitting blue, green, red, and near-infrared biological window light. / Iwano, Satoshi; Obata, Rika; Miura, Chihiro; Kiyama, Masahiro; Hama, Kazutoshi; Nakamura, Mitsuhiro; Amano, Yoshiharu; Kojima, Satoshi; Hirano, Takashi; Maki, Shojiro; Niwa, Haruki.

In: Tetrahedron, Vol. 69, No. 19, 13.05.2013, p. 3847-3856.

Research output: Contribution to journal › Article › peer-review

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AU - Hama, Kazutoshi

AU - Nakamura, Mitsuhiro

AU - Amano, Yoshiharu

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AU - Maki, Shojiro

AU - Niwa, Haruki

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