Development of the Paris definition of early Crohn's disease for disease-modification trials: Results of an international expert opinion process

Laurent Peyrin-Biroulet, Vincent Billioud, Geert D'Haens, Remo Panaccione, Brian Feagan, Julian Panés, Silvio Danese, Stefan Schreiber, Haruhiko Ogata, Toshifumi Hibi, Peter D.R. Higgins, Laurent Beaugerie, Yehuda Chowers, Edouard Louis, Flávio Steinwurz, Walter Reinisch, Paul Rutgeerts, Jean Frédéric Colombel, Simon Travis, William J. Sandborn

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

We report the findings and outputs of an international expert opinion process to develop a definition of early Crohn's disease (CD) that could be used in future disease-modification trials. Nineteen experts on inflammatory bowel diseases held an international expert opinion meeting to discuss and agree on a definition for early CD to be used in disease-modification trials. The process included literature searches for the relevant basic-science and clinical evidence. A published preliminary definition of early CD was used as the basis for development of a proposed definition that was discussed at the expert opinion meeting. The participants then derived a final definition, based on best current knowledge, that it is hoped will be of practical use in disease-modification trials in CD.

Original languageEnglish
Pages (from-to)1770-1776
Number of pages7
JournalAmerican Journal of Gastroenterology
Volume107
Issue number12
DOIs
Publication statusPublished - 2012 Dec 1

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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    Peyrin-Biroulet, L., Billioud, V., D'Haens, G., Panaccione, R., Feagan, B., Panés, J., Danese, S., Schreiber, S., Ogata, H., Hibi, T., Higgins, P. D. R., Beaugerie, L., Chowers, Y., Louis, E., Steinwurz, F., Reinisch, W., Rutgeerts, P., Colombel, J. F., Travis, S., & Sandborn, W. J. (2012). Development of the Paris definition of early Crohn's disease for disease-modification trials: Results of an international expert opinion process. American Journal of Gastroenterology, 107(12), 1770-1776. https://doi.org/10.1038/ajg.2012.117