Development of the Paris definition of early Crohn's disease for disease-modification trials: Results of an international expert opinion process

Laurent Peyrin-Biroulet, Vincent Billioud, Geert D'Haens, Remo Panaccione, Brian Feagan, Julian Panés, Silvio Danese, Stefan Schreiber, Haruhiko Ogata, Toshifumi Hibi, Peter D R Higgins, Laurent Beaugerie, Yehuda Chowers, Edouard Louis, Flávio Steinwurz, Walter Reinisch, Paul Rutgeerts, Jean Frédéric Colombel, Simon Travis, William J. Sandborn

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

We report the findings and outputs of an international expert opinion process to develop a definition of early Crohn's disease (CD) that could be used in future disease-modification trials. Nineteen experts on inflammatory bowel diseases held an international expert opinion meeting to discuss and agree on a definition for early CD to be used in disease-modification trials. The process included literature searches for the relevant basic-science and clinical evidence. A published preliminary definition of early CD was used as the basis for development of a proposed definition that was discussed at the expert opinion meeting. The participants then derived a final definition, based on best current knowledge, that it is hoped will be of practical use in disease-modification trials in CD.

Original languageEnglish
Pages (from-to)1770-1776
Number of pages7
JournalAmerican Journal of Gastroenterology
Volume107
Issue number12
DOIs
Publication statusPublished - 2012 Dec

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Expert Testimony
Paris
Crohn Disease
Inflammatory Bowel Diseases

ASJC Scopus subject areas

  • Gastroenterology

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Development of the Paris definition of early Crohn's disease for disease-modification trials : Results of an international expert opinion process. / Peyrin-Biroulet, Laurent; Billioud, Vincent; D'Haens, Geert; Panaccione, Remo; Feagan, Brian; Panés, Julian; Danese, Silvio; Schreiber, Stefan; Ogata, Haruhiko; Hibi, Toshifumi; Higgins, Peter D R; Beaugerie, Laurent; Chowers, Yehuda; Louis, Edouard; Steinwurz, Flávio; Reinisch, Walter; Rutgeerts, Paul; Colombel, Jean Frédéric; Travis, Simon; Sandborn, William J.

In: American Journal of Gastroenterology, Vol. 107, No. 12, 12.2012, p. 1770-1776.

Research output: Contribution to journalArticle

Peyrin-Biroulet, L, Billioud, V, D'Haens, G, Panaccione, R, Feagan, B, Panés, J, Danese, S, Schreiber, S, Ogata, H, Hibi, T, Higgins, PDR, Beaugerie, L, Chowers, Y, Louis, E, Steinwurz, F, Reinisch, W, Rutgeerts, P, Colombel, JF, Travis, S & Sandborn, WJ 2012, 'Development of the Paris definition of early Crohn's disease for disease-modification trials: Results of an international expert opinion process', American Journal of Gastroenterology, vol. 107, no. 12, pp. 1770-1776. https://doi.org/10.1038/ajg.2012.117
Peyrin-Biroulet, Laurent ; Billioud, Vincent ; D'Haens, Geert ; Panaccione, Remo ; Feagan, Brian ; Panés, Julian ; Danese, Silvio ; Schreiber, Stefan ; Ogata, Haruhiko ; Hibi, Toshifumi ; Higgins, Peter D R ; Beaugerie, Laurent ; Chowers, Yehuda ; Louis, Edouard ; Steinwurz, Flávio ; Reinisch, Walter ; Rutgeerts, Paul ; Colombel, Jean Frédéric ; Travis, Simon ; Sandborn, William J. / Development of the Paris definition of early Crohn's disease for disease-modification trials : Results of an international expert opinion process. In: American Journal of Gastroenterology. 2012 ; Vol. 107, No. 12. pp. 1770-1776.
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