Developmental biology

fgf20 is essential for initiating zebrafish fin regeneration

Geoffrey G. Whitehead, Shinji Makino, Ching Ling Lien, Mark T. Keating

Research output: Contribution to journalArticle

191 Citations (Scopus)

Abstract

Epimorphic regeneration requires the presence or creation of pluripotent cells capable of reproducing lost organs. Zebrafish fin regeneration is mediated by the creation of blastema cells. Here, we characterize the devoid of blastema (dob) mutant that fails fin regeneration during initial steps, forms abnormal regeneration epithelium, and does not form blastema. This mutation has no impact on embryonic survival. Dob results from an fgf20a null mutation, Y148S. Fgf20a is expressed during initiation of fin regeneration at the epithelial-mesenchymal boundary and later overlaps with the blastema marker msxb. Thus, fgf20a has a regeneration-specific requirement, initiating fin regeneration, and controlling blastema formation.

Original languageEnglish
Pages (from-to)1957-1960
Number of pages4
JournalScience
Volume310
Issue number5756
DOIs
Publication statusPublished - 2005 Dec 23
Externally publishedYes

Fingerprint

Developmental Biology
Zebrafish
Regeneration
Mutation
Epithelium

ASJC Scopus subject areas

  • General

Cite this

Developmental biology : fgf20 is essential for initiating zebrafish fin regeneration. / Whitehead, Geoffrey G.; Makino, Shinji; Lien, Ching Ling; Keating, Mark T.

In: Science, Vol. 310, No. 5756, 23.12.2005, p. 1957-1960.

Research output: Contribution to journalArticle

Whitehead, Geoffrey G. ; Makino, Shinji ; Lien, Ching Ling ; Keating, Mark T. / Developmental biology : fgf20 is essential for initiating zebrafish fin regeneration. In: Science. 2005 ; Vol. 310, No. 5756. pp. 1957-1960.
@article{3c7fcb506e4c40d9a6f66d4ce65143d1,
title = "Developmental biology: fgf20 is essential for initiating zebrafish fin regeneration",
abstract = "Epimorphic regeneration requires the presence or creation of pluripotent cells capable of reproducing lost organs. Zebrafish fin regeneration is mediated by the creation of blastema cells. Here, we characterize the devoid of blastema (dob) mutant that fails fin regeneration during initial steps, forms abnormal regeneration epithelium, and does not form blastema. This mutation has no impact on embryonic survival. Dob results from an fgf20a null mutation, Y148S. Fgf20a is expressed during initiation of fin regeneration at the epithelial-mesenchymal boundary and later overlaps with the blastema marker msxb. Thus, fgf20a has a regeneration-specific requirement, initiating fin regeneration, and controlling blastema formation.",
author = "Whitehead, {Geoffrey G.} and Shinji Makino and Lien, {Ching Ling} and Keating, {Mark T.}",
year = "2005",
month = "12",
day = "23",
doi = "10.1126/science.1117637",
language = "English",
volume = "310",
pages = "1957--1960",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "5756",

}

TY - JOUR

T1 - Developmental biology

T2 - fgf20 is essential for initiating zebrafish fin regeneration

AU - Whitehead, Geoffrey G.

AU - Makino, Shinji

AU - Lien, Ching Ling

AU - Keating, Mark T.

PY - 2005/12/23

Y1 - 2005/12/23

N2 - Epimorphic regeneration requires the presence or creation of pluripotent cells capable of reproducing lost organs. Zebrafish fin regeneration is mediated by the creation of blastema cells. Here, we characterize the devoid of blastema (dob) mutant that fails fin regeneration during initial steps, forms abnormal regeneration epithelium, and does not form blastema. This mutation has no impact on embryonic survival. Dob results from an fgf20a null mutation, Y148S. Fgf20a is expressed during initiation of fin regeneration at the epithelial-mesenchymal boundary and later overlaps with the blastema marker msxb. Thus, fgf20a has a regeneration-specific requirement, initiating fin regeneration, and controlling blastema formation.

AB - Epimorphic regeneration requires the presence or creation of pluripotent cells capable of reproducing lost organs. Zebrafish fin regeneration is mediated by the creation of blastema cells. Here, we characterize the devoid of blastema (dob) mutant that fails fin regeneration during initial steps, forms abnormal regeneration epithelium, and does not form blastema. This mutation has no impact on embryonic survival. Dob results from an fgf20a null mutation, Y148S. Fgf20a is expressed during initiation of fin regeneration at the epithelial-mesenchymal boundary and later overlaps with the blastema marker msxb. Thus, fgf20a has a regeneration-specific requirement, initiating fin regeneration, and controlling blastema formation.

UR - http://www.scopus.com/inward/record.url?scp=29344463583&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=29344463583&partnerID=8YFLogxK

U2 - 10.1126/science.1117637

DO - 10.1126/science.1117637

M3 - Article

VL - 310

SP - 1957

EP - 1960

JO - Science

JF - Science

SN - 0036-8075

IS - 5756

ER -