Developmental biology: fgf20 is essential for initiating zebrafish fin regeneration

Geoffrey G. Whitehead, Shinji Makino, Ching Ling Lien, Mark T. Keating

Research output: Contribution to journalArticlepeer-review

208 Citations (Scopus)

Abstract

Epimorphic regeneration requires the presence or creation of pluripotent cells capable of reproducing lost organs. Zebrafish fin regeneration is mediated by the creation of blastema cells. Here, we characterize the devoid of blastema (dob) mutant that fails fin regeneration during initial steps, forms abnormal regeneration epithelium, and does not form blastema. This mutation has no impact on embryonic survival. Dob results from an fgf20a null mutation, Y148S. Fgf20a is expressed during initiation of fin regeneration at the epithelial-mesenchymal boundary and later overlaps with the blastema marker msxb. Thus, fgf20a has a regeneration-specific requirement, initiating fin regeneration, and controlling blastema formation.

Original languageEnglish
Pages (from-to)1957-1960
Number of pages4
JournalScience
Volume310
Issue number5756
DOIs
Publication statusPublished - 2005 Dec 23
Externally publishedYes

ASJC Scopus subject areas

  • General

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