Developmental distribution of coxsackie virus and adenovirus receptor localized in the nervous system

Yuko Hotta, Takao Honda, Makoto Naito, Ryozo Kuwano

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Mouse coxsackie virus and adenovirus receptor (mCAR), which was isolated from the nerve growth cone-enriched fraction of newborn mouse brains, is a member of immunoglobulin-super family, and functions as a homophilic adhesion molecule. We observed the expression of mCAR in embryos to adult tissues by means of immunohistochemical analysis with a peptide antibody. mCAR expression was first detected in the embryonic ectoderm in the uterus on embryonic day 6.5 (E6.5). Then it was strongly expressed in the neuroepithelium of the neural tube, the developing brain and the spinal cord from E8.5 to postnatal day 7 (P7), in the cranial motor nerves from E9.5 to E11.5, and in the optic nerve from E13.5 to P7, which agrees with periods of their respective morphogenetic peaks. This expression of mCAR decreased postnatally and was absent in adult tissues. We found that mCAR occurred in a few proliferating cells of the hippocampal dentate gyrus, the subventricular zone (SVZ) of the lateral ventricles, and the rostral migratory stream (RMS) over P21. These observations demonstrate that mCAR was expressed characteristically in the immature neuroepithelium including progenitor cells or radial cells derived from the neural tube and in immature cells in a selected germinal zone of the mature brain. Based on our findings, we propose that mCAR is involved in migration and fasciculation during a restricted period as an adhesion molecule.

Original languageEnglish
Pages (from-to)1-13
Number of pages13
JournalDevelopmental Brain Research
Volume143
Issue number1
DOIs
Publication statusPublished - 2003 Jun 12
Externally publishedYes

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Coxsackie and Adenovirus Receptor-Like Membrane Protein
Virus Receptors
Enterovirus
Nervous System
Neural Tube
Lateral Ventricles
Brain
Fasciculation
Parahippocampal Gyrus
Growth Cones
Ectoderm
Cranial Nerves
Dentate Gyrus
Optic Nerve
Uterus
Immunoglobulins
Spinal Cord
Stem Cells
Embryonic Structures

Keywords

  • Adenovirus receptor
  • Coxsackie virus
  • Nervous system

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

Cite this

Developmental distribution of coxsackie virus and adenovirus receptor localized in the nervous system. / Hotta, Yuko; Honda, Takao; Naito, Makoto; Kuwano, Ryozo.

In: Developmental Brain Research, Vol. 143, No. 1, 12.06.2003, p. 1-13.

Research output: Contribution to journalArticle

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