Developmental expression of the inositol 1,4,5-trisphosphate receptor and localization of inositol 1,4,5-trisphosphate during early embryogenesis in Xenopus laevis

Shoen Kume, Akira Muto, Hideyuki Okano, Katsuhiko Mikoshiba

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

To study the role of inositol 1,4,5-trisphosphate (IP3) receptors during early embryogenesis in Xenopus, we examined the temporal-spatial localization of Xenopus IP3 receptor (XIP3R), XIP3R protein is enriched in the animal hemisphere of early cleavage stage embryos and becomes localized in the ectoderm and involuted mesoderm in gastrula stage embryos. Up to tailbud stages, expression of XIP3R is observed in the mesodermal tissues and in most subregions of the central nervous system. A quantitative analysis of endogenous IP3 mass during normal early embryogenesis revealed an increase in IP3 mass first observed at early gastrula stage of 10.5 with an enrichment in the ectoderm throughout the gastrula stages, implying a potential role during gastrulation.

Original languageEnglish
Pages (from-to)157-168
Number of pages12
JournalMechanisms of Development
Volume66
Issue number1-2
DOIs
Publication statusPublished - 1997 Aug
Externally publishedYes

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Inositol 1,4,5-Trisphosphate Receptors
Inositol 1,4,5-Trisphosphate
Xenopus laevis
Xenopus
Gastrula
Embryonic Development
Ectoderm
Embryonic Structures
Gastrulation
Mesoderm
Central Nervous System
Proteins

Keywords

  • IP
  • IP receptor
  • Localization
  • Xenopus

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

Cite this

Developmental expression of the inositol 1,4,5-trisphosphate receptor and localization of inositol 1,4,5-trisphosphate during early embryogenesis in Xenopus laevis. / Kume, Shoen; Muto, Akira; Okano, Hideyuki; Mikoshiba, Katsuhiko.

In: Mechanisms of Development, Vol. 66, No. 1-2, 08.1997, p. 157-168.

Research output: Contribution to journalArticle

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