Developmental regression of hyaloid vasculature is triggered by neurons

Yusuke Yoshikawa, Toru Yamada, Ikue Tai-Nagara, Keisuke Okabe, Yuukou Kitagawa, Masatsugu Ema, Yoshiaki Kubota

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Vascular development involves not only vascular growth, but also regression of transient or unnecessary vessels. Hyaloid vasculature is the temporary circulatory system in fetal eyes, which spontaneously degenerates when the retinal blood vessels start to grow. Failure of the hyaloid vessels to regress leads to disease in humans, persistent hyperplastic primary vitreous, which causes severe intraocular hemorrhage and impairs visual function. However, the mechanism underlying the endogenous program that mediates spontaneous regression of the hyaloid vessels is not well understood. In this study, we identify a robust switch triggering this program directed by neurons in mice. Marked up-regulation of vascular endothelial growth factor (VEGF) receptor 2 (VEG FR2) occurs in retinal neurons just after birth via distal-multipotent-mesodermal enhancer, a hemangioblast- specific enhancer of VEG FR2. Genetic deletion of neuronal VEG FR2 interrupts this program, resulting in massive hyaloid vessels that persist even during late postnatal days. This abnormality is caused by excessive VEGF proteins in the vitreous cavity as a result of impairment in the neuronal sequestration of VEGF. Collectively, our data indicate that neurons trigger transition from the fetal to the postnatal circulatory systems in the retina.

Original languageEnglish
Pages (from-to)1175-1183
Number of pages9
JournalJournal of Experimental Medicine
Volume213
Issue number7
DOIs
Publication statusPublished - 2016

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Vascular Endothelial Growth Factor Receptor
Cardiovascular System
Vascular Endothelial Growth Factor A
Blood Vessels
Persistent Hyperplastic Primary Vitreous
Hemangioblasts
Retinal Neurons
Neurons
Retinal Vessels
Vascular Endothelial Growth Factor Receptor-2
Retina
Up-Regulation
Parturition
Hemorrhage
Growth
Proteins

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Developmental regression of hyaloid vasculature is triggered by neurons. / Yoshikawa, Yusuke; Yamada, Toru; Tai-Nagara, Ikue; Okabe, Keisuke; Kitagawa, Yuukou; Ema, Masatsugu; Kubota, Yoshiaki.

In: Journal of Experimental Medicine, Vol. 213, No. 7, 2016, p. 1175-1183.

Research output: Contribution to journalArticle

Yoshikawa, Yusuke ; Yamada, Toru ; Tai-Nagara, Ikue ; Okabe, Keisuke ; Kitagawa, Yuukou ; Ema, Masatsugu ; Kubota, Yoshiaki. / Developmental regression of hyaloid vasculature is triggered by neurons. In: Journal of Experimental Medicine. 2016 ; Vol. 213, No. 7. pp. 1175-1183.
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