TY - JOUR
T1 - Developmental Roles and Evolutionary Significance of AMPA-Type Glutamate Receptors
AU - Hirai, Shinobu
AU - Hotta, Kohji
AU - Okado, Haruo
N1 - Funding Information:
This work was supported by grants from the Japan Society for the Promotion of Science (KAKENHI 26830033 [to S.H.], 16K07426, and 16H01451 [to K.H.], and 16K14569 and 26290016 [to H.O.]). The authors thank Ms. E. Wakatsuki for generating the figures.
Publisher Copyright:
© 2018 WILEY Periodicals, Inc.
PY - 2018/9
Y1 - 2018/9
N2 - Organogenesis and metamorphosis require the intricate orchestration of multiple types of cellular interactions and signaling pathways. Glutamate (Glu) is an excitatory extracellular signaling molecule in the nervous system, while Ca 2+ is a major intracellular signaling molecule. The first Glu receptors to be cloned are Ca 2+ -permeable receptors in mammalian brains. Although recent studies have focused on Glu signaling in synaptic mechanisms of the mammalian central nervous system, it is unclear how this signaling functions in development. Our recent article demonstrated that Ca 2+ -permeable AMPA-type Glu receptors (GluAs) are essential for formation of a photosensitive organ, development of some neurons, and metamorphosis, including tail absorption and body axis rotation, in ascidian embryos. Based on findings in these embryos and mammalian brains, we formed several hypotheses regarding the evolution of GluAs, the non-synaptic function of Glu, the origin of GluA-positive neurons, and the neuronal network that controls metamorphosis in ascidians.
AB - Organogenesis and metamorphosis require the intricate orchestration of multiple types of cellular interactions and signaling pathways. Glutamate (Glu) is an excitatory extracellular signaling molecule in the nervous system, while Ca 2+ is a major intracellular signaling molecule. The first Glu receptors to be cloned are Ca 2+ -permeable receptors in mammalian brains. Although recent studies have focused on Glu signaling in synaptic mechanisms of the mammalian central nervous system, it is unclear how this signaling functions in development. Our recent article demonstrated that Ca 2+ -permeable AMPA-type Glu receptors (GluAs) are essential for formation of a photosensitive organ, development of some neurons, and metamorphosis, including tail absorption and body axis rotation, in ascidian embryos. Based on findings in these embryos and mammalian brains, we formed several hypotheses regarding the evolution of GluAs, the non-synaptic function of Glu, the origin of GluA-positive neurons, and the neuronal network that controls metamorphosis in ascidians.
KW - AMPA-type receptor
KW - ascidian development
KW - calcium permeability
KW - evolution
KW - glutamate receptor
KW - metamorphosis
KW - organ formation
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U2 - 10.1002/bies.201800028
DO - 10.1002/bies.201800028
M3 - Review article
C2 - 30058076
AN - SCOPUS:85051028218
SN - 0265-9247
VL - 40
JO - BioEssays
JF - BioEssays
IS - 9
M1 - 1800028
ER -