Abstract
Properties of local synapses were analyzed in lobus parolfactorius (LPO; avian homologue of caudate-nucleus) of quail chicks by using slice preparations in vitro. Field-potential extracellular and whole-cell intracellular recordings revealed excitatory synaptic inputs converging from dorsal and ventral regions within LPO. With exogenous dopamine (100 μM) in the perfusate, synchronized conditioning stimulation induced biased changes in the dorsal and the ventral inputs; potentiation in the dorsal input and depression in the ventral input in average. On the other hand, de-synchronized conditioning failed to induce such biased changes, although the differences were not statistically significant. SCH-23390 (3 μM) blocked the dorsal potentiation, while AP-5 (100 μM) tended to block both of these changes. The plastic nature may underlie the memory formation in appetitive/aversive learning tasks.
| Original language | English |
|---|---|
| Pages (from-to) | 2831-2837 |
| Number of pages | 7 |
| Journal | NeuroReport |
| Volume | 12 |
| Issue number | 13 |
| Publication status | Published - 2001 Sep 17 |
| Externally published | Yes |
Fingerprint
Keywords
- Bird
- Caudate nucleus
- Dopamine receptors
- Learning
- Lobus parolfactorius
- Long-term potentiation
- Neostriatum
- NMDA receptor
- Passive avoidance task
- Reinforcement
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Di-receptor dependent synaptic potentiation in the basal ganglia of quail chicks. / Matsushima, Toshiya; Izawa, Eiichi; Yanagihara, Shin.
In: NeuroReport, Vol. 12, No. 13, 17.09.2001, p. 2831-2837.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Di-receptor dependent synaptic potentiation in the basal ganglia of quail chicks
AU - Matsushima, Toshiya
AU - Izawa, Eiichi
AU - Yanagihara, Shin
PY - 2001/9/17
Y1 - 2001/9/17
N2 - Properties of local synapses were analyzed in lobus parolfactorius (LPO; avian homologue of caudate-nucleus) of quail chicks by using slice preparations in vitro. Field-potential extracellular and whole-cell intracellular recordings revealed excitatory synaptic inputs converging from dorsal and ventral regions within LPO. With exogenous dopamine (100 μM) in the perfusate, synchronized conditioning stimulation induced biased changes in the dorsal and the ventral inputs; potentiation in the dorsal input and depression in the ventral input in average. On the other hand, de-synchronized conditioning failed to induce such biased changes, although the differences were not statistically significant. SCH-23390 (3 μM) blocked the dorsal potentiation, while AP-5 (100 μM) tended to block both of these changes. The plastic nature may underlie the memory formation in appetitive/aversive learning tasks.
AB - Properties of local synapses were analyzed in lobus parolfactorius (LPO; avian homologue of caudate-nucleus) of quail chicks by using slice preparations in vitro. Field-potential extracellular and whole-cell intracellular recordings revealed excitatory synaptic inputs converging from dorsal and ventral regions within LPO. With exogenous dopamine (100 μM) in the perfusate, synchronized conditioning stimulation induced biased changes in the dorsal and the ventral inputs; potentiation in the dorsal input and depression in the ventral input in average. On the other hand, de-synchronized conditioning failed to induce such biased changes, although the differences were not statistically significant. SCH-23390 (3 μM) blocked the dorsal potentiation, while AP-5 (100 μM) tended to block both of these changes. The plastic nature may underlie the memory formation in appetitive/aversive learning tasks.
KW - Bird
KW - Caudate nucleus
KW - Dopamine receptors
KW - Learning
KW - Lobus parolfactorius
KW - Long-term potentiation
KW - Neostriatum
KW - NMDA receptor
KW - Passive avoidance task
KW - Reinforcement
UR - http://www.scopus.com/inward/record.url?scp=0035903268&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035903268&partnerID=8YFLogxK
M3 - Article
C2 - 11588586
AN - SCOPUS:0035903268
VL - 12
SP - 2831
EP - 2837
JO - NeuroReport
JF - NeuroReport
SN - 0959-4965
IS - 13
ER -