Abstract
Properties of local synapses were analyzed in lobus parolfactorius (LPO; avian homologue of caudate-nucleus) of quail chicks by using slice preparations in vitro. Field-potential extracellular and whole-cell intracellular recordings revealed excitatory synaptic inputs converging from dorsal and ventral regions within LPO. With exogenous dopamine (100 μM) in the perfusate, synchronized conditioning stimulation induced biased changes in the dorsal and the ventral inputs; potentiation in the dorsal input and depression in the ventral input in average. On the other hand, de-synchronized conditioning failed to induce such biased changes, although the differences were not statistically significant. SCH-23390 (3 μM) blocked the dorsal potentiation, while AP-5 (100 μM) tended to block both of these changes. The plastic nature may underlie the memory formation in appetitive/aversive learning tasks.
Original language | English |
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Pages (from-to) | 2831-2837 |
Number of pages | 7 |
Journal | NeuroReport |
Volume | 12 |
Issue number | 13 |
DOIs | |
Publication status | Published - 2001 Sep 17 |
Externally published | Yes |
Keywords
- Bird
- Caudate nucleus
- Dopamine receptors
- Learning
- Lobus parolfactorius
- Long-term potentiation
- NMDA receptor
- Neostriatum
- Passive avoidance task
- Reinforcement
ASJC Scopus subject areas
- Neuroscience(all)