Di-receptor dependent synaptic potentiation in the basal ganglia of quail chicks

Toshiya Matsushima, Ei Ichi Izawa, Shin Yanagihara

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Properties of local synapses were analyzed in lobus parolfactorius (LPO; avian homologue of caudate-nucleus) of quail chicks by using slice preparations in vitro. Field-potential extracellular and whole-cell intracellular recordings revealed excitatory synaptic inputs converging from dorsal and ventral regions within LPO. With exogenous dopamine (100 μM) in the perfusate, synchronized conditioning stimulation induced biased changes in the dorsal and the ventral inputs; potentiation in the dorsal input and depression in the ventral input in average. On the other hand, de-synchronized conditioning failed to induce such biased changes, although the differences were not statistically significant. SCH-23390 (3 μM) blocked the dorsal potentiation, while AP-5 (100 μM) tended to block both of these changes. The plastic nature may underlie the memory formation in appetitive/aversive learning tasks.

Original languageEnglish
Pages (from-to)2831-2837
Number of pages7
JournalNeuroReport
Volume12
Issue number13
DOIs
Publication statusPublished - 2001 Sep 17
Externally publishedYes

Keywords

  • Bird
  • Caudate nucleus
  • Dopamine receptors
  • Learning
  • Lobus parolfactorius
  • Long-term potentiation
  • NMDA receptor
  • Neostriatum
  • Passive avoidance task
  • Reinforcement

ASJC Scopus subject areas

  • Neuroscience(all)

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