Diabetes mellitus associated with 3243 mitochondrial tRNA (Leu(UUR)) mutation

Clinical features and coenzyme Q10 treatment

Y. Suzuki, M. Taniyama, Taro Muramatsu, Y. Atsumi, K. Hosokawa, T. Asahina, A. Shimada, C. Murata, K. Matsuoka

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Diabetes mellitus associated with mitochondrial tRNA mutation at position 3243(DM-Mt3243) is a new disease. Patients have a distinctly different picture from MELAS (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes). During observations at the Saiseikai Central Hospital, the following findings were noted in DM-Mt3243 patients: DM-Mt3243 patients are diagnosed earlier with diabetes, compared to NIDDM (non-insulin dependent diabetes mellitus) controls without family history. DM-Mt3243 patients often need insulin more often than NIDDM controls without family history. Post-treatment neuropathy and insulin edema are often found in DM-Mt3243, and the two phenomena possibly have a similar pathophysiology related to mitochondrial dysfunction. Ambiguous psychiatric disorders of functional psychosis are observed frequently in DM-Mt3243. Mild headache is common in DM-Mt3243 cases. Ambiguous neuromuscular abnormaltiies such as sleep disturbance, paresthesia of the legs, edema of the legs, and palpitation may be symptoms associated with mitochondrial dysfunction in DM-Mt3243. Coenzyme a maybe effective in the relief of these neuromuscular symptoms.

Original languageEnglish
JournalMolecular Aspects of Medicine
Volume18
Issue numberSUPPL.
DOIs
Publication statusPublished - 1997
Externally publishedYes

Fingerprint

coenzyme Q10
RNA, Transfer, Leu
Medical problems
Diabetes Mellitus
Mutation
Type 2 Diabetes Mellitus
Edema
Leg
MELAS Syndrome
Insulin
Paresthesia
Coenzymes
Therapeutics
Transfer RNA
Psychotic Disorders
Headache
Psychiatry
Sleep

Keywords

  • ALDH2
  • Coenzyme Q
  • MELAS
  • Mitochondrial diabetes mellitus
  • Mitochondrial DNA mutation at position 3243

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Molecular Medicine

Cite this

Diabetes mellitus associated with 3243 mitochondrial tRNA (Leu(UUR)) mutation : Clinical features and coenzyme Q10 treatment. / Suzuki, Y.; Taniyama, M.; Muramatsu, Taro; Atsumi, Y.; Hosokawa, K.; Asahina, T.; Shimada, A.; Murata, C.; Matsuoka, K.

In: Molecular Aspects of Medicine, Vol. 18, No. SUPPL., 1997.

Research output: Contribution to journalArticle

Suzuki, Y. ; Taniyama, M. ; Muramatsu, Taro ; Atsumi, Y. ; Hosokawa, K. ; Asahina, T. ; Shimada, A. ; Murata, C. ; Matsuoka, K. / Diabetes mellitus associated with 3243 mitochondrial tRNA (Leu(UUR)) mutation : Clinical features and coenzyme Q10 treatment. In: Molecular Aspects of Medicine. 1997 ; Vol. 18, No. SUPPL.
@article{9e699ca4a01f4f3e90cd5c65785b4032,
title = "Diabetes mellitus associated with 3243 mitochondrial tRNA (Leu(UUR)) mutation: Clinical features and coenzyme Q10 treatment",
abstract = "Diabetes mellitus associated with mitochondrial tRNA mutation at position 3243(DM-Mt3243) is a new disease. Patients have a distinctly different picture from MELAS (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes). During observations at the Saiseikai Central Hospital, the following findings were noted in DM-Mt3243 patients: DM-Mt3243 patients are diagnosed earlier with diabetes, compared to NIDDM (non-insulin dependent diabetes mellitus) controls without family history. DM-Mt3243 patients often need insulin more often than NIDDM controls without family history. Post-treatment neuropathy and insulin edema are often found in DM-Mt3243, and the two phenomena possibly have a similar pathophysiology related to mitochondrial dysfunction. Ambiguous psychiatric disorders of functional psychosis are observed frequently in DM-Mt3243. Mild headache is common in DM-Mt3243 cases. Ambiguous neuromuscular abnormaltiies such as sleep disturbance, paresthesia of the legs, edema of the legs, and palpitation may be symptoms associated with mitochondrial dysfunction in DM-Mt3243. Coenzyme a maybe effective in the relief of these neuromuscular symptoms.",
keywords = "ALDH2, Coenzyme Q, MELAS, Mitochondrial diabetes mellitus, Mitochondrial DNA mutation at position 3243",
author = "Y. Suzuki and M. Taniyama and Taro Muramatsu and Y. Atsumi and K. Hosokawa and T. Asahina and A. Shimada and C. Murata and K. Matsuoka",
year = "1997",
doi = "10.1016/S0098-2997(97)00041-1",
language = "English",
volume = "18",
journal = "Molecular Aspects of Medicine",
issn = "0098-2997",
publisher = "Elsevier Limited",
number = "SUPPL.",

}

TY - JOUR

T1 - Diabetes mellitus associated with 3243 mitochondrial tRNA (Leu(UUR)) mutation

T2 - Clinical features and coenzyme Q10 treatment

AU - Suzuki, Y.

AU - Taniyama, M.

AU - Muramatsu, Taro

AU - Atsumi, Y.

AU - Hosokawa, K.

AU - Asahina, T.

AU - Shimada, A.

AU - Murata, C.

AU - Matsuoka, K.

PY - 1997

Y1 - 1997

N2 - Diabetes mellitus associated with mitochondrial tRNA mutation at position 3243(DM-Mt3243) is a new disease. Patients have a distinctly different picture from MELAS (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes). During observations at the Saiseikai Central Hospital, the following findings were noted in DM-Mt3243 patients: DM-Mt3243 patients are diagnosed earlier with diabetes, compared to NIDDM (non-insulin dependent diabetes mellitus) controls without family history. DM-Mt3243 patients often need insulin more often than NIDDM controls without family history. Post-treatment neuropathy and insulin edema are often found in DM-Mt3243, and the two phenomena possibly have a similar pathophysiology related to mitochondrial dysfunction. Ambiguous psychiatric disorders of functional psychosis are observed frequently in DM-Mt3243. Mild headache is common in DM-Mt3243 cases. Ambiguous neuromuscular abnormaltiies such as sleep disturbance, paresthesia of the legs, edema of the legs, and palpitation may be symptoms associated with mitochondrial dysfunction in DM-Mt3243. Coenzyme a maybe effective in the relief of these neuromuscular symptoms.

AB - Diabetes mellitus associated with mitochondrial tRNA mutation at position 3243(DM-Mt3243) is a new disease. Patients have a distinctly different picture from MELAS (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes). During observations at the Saiseikai Central Hospital, the following findings were noted in DM-Mt3243 patients: DM-Mt3243 patients are diagnosed earlier with diabetes, compared to NIDDM (non-insulin dependent diabetes mellitus) controls without family history. DM-Mt3243 patients often need insulin more often than NIDDM controls without family history. Post-treatment neuropathy and insulin edema are often found in DM-Mt3243, and the two phenomena possibly have a similar pathophysiology related to mitochondrial dysfunction. Ambiguous psychiatric disorders of functional psychosis are observed frequently in DM-Mt3243. Mild headache is common in DM-Mt3243 cases. Ambiguous neuromuscular abnormaltiies such as sleep disturbance, paresthesia of the legs, edema of the legs, and palpitation may be symptoms associated with mitochondrial dysfunction in DM-Mt3243. Coenzyme a maybe effective in the relief of these neuromuscular symptoms.

KW - ALDH2

KW - Coenzyme Q

KW - MELAS

KW - Mitochondrial diabetes mellitus

KW - Mitochondrial DNA mutation at position 3243

UR - http://www.scopus.com/inward/record.url?scp=0030823104&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030823104&partnerID=8YFLogxK

U2 - 10.1016/S0098-2997(97)00041-1

DO - 10.1016/S0098-2997(97)00041-1

M3 - Article

VL - 18

JO - Molecular Aspects of Medicine

JF - Molecular Aspects of Medicine

SN - 0098-2997

IS - SUPPL.

ER -