Diagnosis and therapies for gastric non-invasive neoplasia

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

There has been a great discrepancy of pathological diagnosis for gastric non-invasive neoplasia/dysplasia between Japanese and western pathologists. In Japan, lesions that most western pathologists diagnose as dysplasia are often considered adenocarcinoma based on nuclear and structural atypia regardless of the presence of invasion. In the Vienna classification, gastric non-invasive intraepithelial neoplasia (NIN) were divided into low grade and high grade (including intramucosal cancer of Japanese criteria). The diagnosis by both endoscopy and pathology of biopsy specimen is difficult. Recent advances of diagnostic modality such as magnified endoscopy and imaged enhanced endoscopy is expected to improve the diagnostic yield for NIN. There are two treatment strategies for NIN, observation and diagnostic therapy by endoscopic resection (ER). ER is acceptable because of its less invasiveness and high local control rate, on the other hand, cancer-developing rate of low-grade NIN is reported to be low. Therefore there is controversy for the treatment of gastric NIN. Prospective study based on unified pathological definition is required in the future.

Original languageEnglish
Pages (from-to)12513-12518
Number of pages6
JournalWorld Journal of Gastroenterology
Volume21
Issue number44
DOIs
Publication statusPublished - 2015 Nov 28
Externally publishedYes

Fingerprint

Stomach
Neoplasms
Endoscopy
Therapeutics
Japan
Adenocarcinoma
Observation
Prospective Studies
Pathology
Biopsy

Keywords

  • Adenocarcinoma
  • Adenoma
  • Diagnosis
  • Gastric
  • Gastric
  • Non invasive intraepithelial neoplasia

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Diagnosis and therapies for gastric non-invasive neoplasia. / Kato, Motohiko.

In: World Journal of Gastroenterology, Vol. 21, No. 44, 28.11.2015, p. 12513-12518.

Research output: Contribution to journalReview article

@article{6d170a3d9678499785b85c5645cde21f,
title = "Diagnosis and therapies for gastric non-invasive neoplasia",
abstract = "There has been a great discrepancy of pathological diagnosis for gastric non-invasive neoplasia/dysplasia between Japanese and western pathologists. In Japan, lesions that most western pathologists diagnose as dysplasia are often considered adenocarcinoma based on nuclear and structural atypia regardless of the presence of invasion. In the Vienna classification, gastric non-invasive intraepithelial neoplasia (NIN) were divided into low grade and high grade (including intramucosal cancer of Japanese criteria). The diagnosis by both endoscopy and pathology of biopsy specimen is difficult. Recent advances of diagnostic modality such as magnified endoscopy and imaged enhanced endoscopy is expected to improve the diagnostic yield for NIN. There are two treatment strategies for NIN, observation and diagnostic therapy by endoscopic resection (ER). ER is acceptable because of its less invasiveness and high local control rate, on the other hand, cancer-developing rate of low-grade NIN is reported to be low. Therefore there is controversy for the treatment of gastric NIN. Prospective study based on unified pathological definition is required in the future.",
keywords = "Adenocarcinoma, Adenoma, Diagnosis, Gastric, Gastric, Non invasive intraepithelial neoplasia",
author = "Motohiko Kato",
year = "2015",
month = "11",
day = "28",
doi = "10.3748/wjg.v21.i44.12513",
language = "English",
volume = "21",
pages = "12513--12518",
journal = "World Journal of Gastroenterology",
issn = "1007-9327",
publisher = "WJG Press",
number = "44",

}

TY - JOUR

T1 - Diagnosis and therapies for gastric non-invasive neoplasia

AU - Kato, Motohiko

PY - 2015/11/28

Y1 - 2015/11/28

N2 - There has been a great discrepancy of pathological diagnosis for gastric non-invasive neoplasia/dysplasia between Japanese and western pathologists. In Japan, lesions that most western pathologists diagnose as dysplasia are often considered adenocarcinoma based on nuclear and structural atypia regardless of the presence of invasion. In the Vienna classification, gastric non-invasive intraepithelial neoplasia (NIN) were divided into low grade and high grade (including intramucosal cancer of Japanese criteria). The diagnosis by both endoscopy and pathology of biopsy specimen is difficult. Recent advances of diagnostic modality such as magnified endoscopy and imaged enhanced endoscopy is expected to improve the diagnostic yield for NIN. There are two treatment strategies for NIN, observation and diagnostic therapy by endoscopic resection (ER). ER is acceptable because of its less invasiveness and high local control rate, on the other hand, cancer-developing rate of low-grade NIN is reported to be low. Therefore there is controversy for the treatment of gastric NIN. Prospective study based on unified pathological definition is required in the future.

AB - There has been a great discrepancy of pathological diagnosis for gastric non-invasive neoplasia/dysplasia between Japanese and western pathologists. In Japan, lesions that most western pathologists diagnose as dysplasia are often considered adenocarcinoma based on nuclear and structural atypia regardless of the presence of invasion. In the Vienna classification, gastric non-invasive intraepithelial neoplasia (NIN) were divided into low grade and high grade (including intramucosal cancer of Japanese criteria). The diagnosis by both endoscopy and pathology of biopsy specimen is difficult. Recent advances of diagnostic modality such as magnified endoscopy and imaged enhanced endoscopy is expected to improve the diagnostic yield for NIN. There are two treatment strategies for NIN, observation and diagnostic therapy by endoscopic resection (ER). ER is acceptable because of its less invasiveness and high local control rate, on the other hand, cancer-developing rate of low-grade NIN is reported to be low. Therefore there is controversy for the treatment of gastric NIN. Prospective study based on unified pathological definition is required in the future.

KW - Adenocarcinoma

KW - Adenoma

KW - Diagnosis

KW - Gastric

KW - Gastric

KW - Non invasive intraepithelial neoplasia

UR - http://www.scopus.com/inward/record.url?scp=84948462663&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84948462663&partnerID=8YFLogxK

U2 - 10.3748/wjg.v21.i44.12513

DO - 10.3748/wjg.v21.i44.12513

M3 - Review article

C2 - 26640329

AN - SCOPUS:84948462663

VL - 21

SP - 12513

EP - 12518

JO - World Journal of Gastroenterology

JF - World Journal of Gastroenterology

SN - 1007-9327

IS - 44

ER -