Diagnosis of fatty liver with MR imaging.

B. P. Kreft, Akihiro Tanimoto, Y. Baba, L. Zhao, J. Chen, M. S. Middleton, C. C. Compton, J. P. Finn, D. D. Stark

Research output: Contribution to journalArticle

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Abstract

The diagnosis of fatty liver with magnetic resonance (MR) imaging was evaluated in experimental rat models of simple fatty infiltration and fatty liver with hepatocellular injury. T1 and T2 were measured ex vivo and correlated with the histologic degree of fatty infiltration. Enhancement of fatty liver with four different cells-specific contrast agents was studied with ex vivo relaxometry and in vivo MR imaging. Quantitative analysis of conventional and chemical shift MR images was correlated with biochemically determined fat content of the liver. Diet-induced simple fatty infiltration of the liver caused a decrease in T1 of 15%, whereas the T1 of L-ethionine-induced fatty liver with hepatocellular injury increased by 12%. T2 showed a positive correlation with the degree of fatty infiltration in both models. Cell-specific hepatobiliary contrast agents showed the same liver uptake and relaxation enhancement in fatty livers as in normal livers. Conventional T1-weighted images and chemical shift images showed good correlation (r = .83 and .80, respectively) between signal intensity and the degree of fatty infiltration. However, only chemical shift imaging was reliable in the diagnosis of fatty liver.

Original languageEnglish
Pages (from-to)463-471
Number of pages9
JournalJournal of magnetic resonance imaging : JMRI
Volume2
Issue number4
Publication statusPublished - 1992 Jul
Externally publishedYes

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Fatty Liver
Magnetic Resonance Imaging
Contrast Media
Liver
Ethionine
Wounds and Injuries
Theoretical Models
Magnetic Resonance Spectroscopy
Fats
Diet

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Kreft, B. P., Tanimoto, A., Baba, Y., Zhao, L., Chen, J., Middleton, M. S., ... Stark, D. D. (1992). Diagnosis of fatty liver with MR imaging. Journal of magnetic resonance imaging : JMRI, 2(4), 463-471.

Diagnosis of fatty liver with MR imaging. / Kreft, B. P.; Tanimoto, Akihiro; Baba, Y.; Zhao, L.; Chen, J.; Middleton, M. S.; Compton, C. C.; Finn, J. P.; Stark, D. D.

In: Journal of magnetic resonance imaging : JMRI, Vol. 2, No. 4, 07.1992, p. 463-471.

Research output: Contribution to journalArticle

Kreft, BP, Tanimoto, A, Baba, Y, Zhao, L, Chen, J, Middleton, MS, Compton, CC, Finn, JP & Stark, DD 1992, 'Diagnosis of fatty liver with MR imaging.', Journal of magnetic resonance imaging : JMRI, vol. 2, no. 4, pp. 463-471.
Kreft BP, Tanimoto A, Baba Y, Zhao L, Chen J, Middleton MS et al. Diagnosis of fatty liver with MR imaging. Journal of magnetic resonance imaging : JMRI. 1992 Jul;2(4):463-471.
Kreft, B. P. ; Tanimoto, Akihiro ; Baba, Y. ; Zhao, L. ; Chen, J. ; Middleton, M. S. ; Compton, C. C. ; Finn, J. P. ; Stark, D. D. / Diagnosis of fatty liver with MR imaging. In: Journal of magnetic resonance imaging : JMRI. 1992 ; Vol. 2, No. 4. pp. 463-471.
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