Diagnosis of measles viral pneumonia in a patient with Hodgkin's disease by reverse transcription-polymerase chain reaction of serum

Shigehisa Mori, Hiroshi Maruyama, Isao Ito, Michihide Tokuhira, Jun Koide, Tsutomu Takeuchi, Shinji Itoyama, Atsuko Masunaga, Masao Fukushima, Hiroshi Suzuki, Tohru Abe

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We report a case of fatal measles viral pneumonia in a patient with Hodgkin's disease who had no rash. The measles viral cDNA was detected in autopsy tissue from the lung by reverse transcription-polymerase chain reaction. This method was then applied successfully to stored serum. The diagnosis of measles viral pneumonia may be improved by the application of RT-PCR using peripheral blood. Sequence analysis of amplified cDNA suggested the virus infecting this patient was a recent strain, predominantly isolated after 1980. The fatal outcome may have been due to a lack of immune response to the newer strain.

Original languageEnglish
Pages (from-to)327-331
Number of pages5
JournalInternational Journal of Hematology
Volume68
Issue number3
Publication statusPublished - 1998 Oct
Externally publishedYes

Fingerprint

Viral Pneumonia
Measles
Hodgkin Disease
Reverse Transcription
Polymerase Chain Reaction
Complementary DNA
Serum
Fatal Outcome
Exanthema
Sequence Analysis
Autopsy
Viruses
Lung

Keywords

  • Diagnosis
  • Hodgkin's disease
  • Measles
  • Pneumonia
  • RT-PCR

ASJC Scopus subject areas

  • Hematology

Cite this

Diagnosis of measles viral pneumonia in a patient with Hodgkin's disease by reverse transcription-polymerase chain reaction of serum. / Mori, Shigehisa; Maruyama, Hiroshi; Ito, Isao; Tokuhira, Michihide; Koide, Jun; Takeuchi, Tsutomu; Itoyama, Shinji; Masunaga, Atsuko; Fukushima, Masao; Suzuki, Hiroshi; Abe, Tohru.

In: International Journal of Hematology, Vol. 68, No. 3, 10.1998, p. 327-331.

Research output: Contribution to journalArticle

Mori, S, Maruyama, H, Ito, I, Tokuhira, M, Koide, J, Takeuchi, T, Itoyama, S, Masunaga, A, Fukushima, M, Suzuki, H & Abe, T 1998, 'Diagnosis of measles viral pneumonia in a patient with Hodgkin's disease by reverse transcription-polymerase chain reaction of serum', International Journal of Hematology, vol. 68, no. 3, pp. 327-331.
Mori, Shigehisa ; Maruyama, Hiroshi ; Ito, Isao ; Tokuhira, Michihide ; Koide, Jun ; Takeuchi, Tsutomu ; Itoyama, Shinji ; Masunaga, Atsuko ; Fukushima, Masao ; Suzuki, Hiroshi ; Abe, Tohru. / Diagnosis of measles viral pneumonia in a patient with Hodgkin's disease by reverse transcription-polymerase chain reaction of serum. In: International Journal of Hematology. 1998 ; Vol. 68, No. 3. pp. 327-331.
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