Diagnosis of measles viral pneumonia in a patient with Hodgkin's disease by reverse transcription-polymerase chain reaction of serum

Shigehisa Mori, Hiroshi Maruyama, Isao Ito, Michihide Tokuhira, Jun Koide, Tsutomu Takeuchi, Shinji Itoyama, Atsuko Masunaga, Masao Fukushima, Hiroshi Suzuki, Tohru Abe

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We report a case of fatal measles viral pneumonia in a patient with Hodgkin's disease who had no rash. The measles viral cDNA was detected in autopsy tissue from the lung by reverse transcription-polymerase chain reaction. This method was then applied successfully to stored serum. The diagnosis of measles viral pneumonia may be improved by the application of RT-PCR using peripheral blood. Sequence analysis of amplified cDNA suggested the virus infecting this patient was a recent strain, predominantly isolated after 1980. The fatal outcome may have been due to a lack of immune response to the newer strain.

Original languageEnglish
Pages (from-to)327-331
Number of pages5
JournalInternational journal of hematology
Volume68
Issue number3
DOIs
Publication statusPublished - 1998 Oct

Keywords

  • Diagnosis
  • Hodgkin's disease
  • Measles
  • Pneumonia
  • RT-PCR

ASJC Scopus subject areas

  • Hematology

Fingerprint Dive into the research topics of 'Diagnosis of measles viral pneumonia in a patient with Hodgkin's disease by reverse transcription-polymerase chain reaction of serum'. Together they form a unique fingerprint.

  • Cite this