Diagnostic accuracy of stress myocardial perfusion MRI and late gadolinium-enhanced MRI for detecting flow-limiting coronary artery disease: A multicenter study

Kakuya Kitagawa, Hajime Sakuma, Motonori Nagata, Shigeo Okuda, Masaharu Hirano, Akihiro Tanimoto, Masaki Matsusako, Joao A C Lima, Sachio Kuribayashi, Kan Takeda

Research output: Contribution to journalArticle

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Abstract

The aim of this study was to determine the diagnostic performance of stress and rest perfusion magnetic resonance imaging (MRI) and late gadolinium-enhanced (LGE) MRI for identifying patients with obstructive coronary artery disease (CAD). A total of 50 patients with suspected CAD underwent stress-rest perfusion MRI, followed by LGE MRI with a 1.5-T system. Stress-rest perfusion MRI resulted in an area under the receiver-operating characteristic curve (AUC) of 0.92 for observer 1 and 0.84 for observer 2 with sensitivity and specificity of 89% (32/36) and 79% (11/14) by observer 1, 83% (30/36) and 71% (10/14) by observer 2, respectively, showing a moderate interobserver agreement (Cohen's κ=0.49). While combination of stress-rest perfusion and LGE MRI did not result in improved accuracy for the prediction of flow-limiting obstructive CAD (AUC 0.81 for observer 1 and 0.80 for observer 2), the sensitivity was increased to 92% in both observers with a substantial interobserver agreement (κ=0.70). Stress-rest myocardial perfusion MRI is an accurate diagnostic test for identifying patients with obstructive CAD.

Original languageEnglish
Pages (from-to)2808-2816
Number of pages9
JournalEuropean Radiology
Volume18
Issue number12
DOIs
Publication statusPublished - 2008

Fingerprint

Magnetic Resonance Angiography
Gadolinium
Multicenter Studies
Coronary Artery Disease
Magnetic Resonance Imaging
Area Under Curve
Routine Diagnostic Tests
ROC Curve
Perfusion
Sensitivity and Specificity

Keywords

  • Coronary artery disease
  • Magneticr esonance imaging
  • Multicenter trial
  • Myocardial perfusion
  • Pharmacological stress

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Diagnostic accuracy of stress myocardial perfusion MRI and late gadolinium-enhanced MRI for detecting flow-limiting coronary artery disease : A multicenter study. / Kitagawa, Kakuya; Sakuma, Hajime; Nagata, Motonori; Okuda, Shigeo; Hirano, Masaharu; Tanimoto, Akihiro; Matsusako, Masaki; Lima, Joao A C; Kuribayashi, Sachio; Takeda, Kan.

In: European Radiology, Vol. 18, No. 12, 2008, p. 2808-2816.

Research output: Contribution to journalArticle

Kitagawa, Kakuya ; Sakuma, Hajime ; Nagata, Motonori ; Okuda, Shigeo ; Hirano, Masaharu ; Tanimoto, Akihiro ; Matsusako, Masaki ; Lima, Joao A C ; Kuribayashi, Sachio ; Takeda, Kan. / Diagnostic accuracy of stress myocardial perfusion MRI and late gadolinium-enhanced MRI for detecting flow-limiting coronary artery disease : A multicenter study. In: European Radiology. 2008 ; Vol. 18, No. 12. pp. 2808-2816.
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