Diagnostic capacity of 64-slice multidetector computed tomography for acute coronary syndrome in patients presenting with acute chest pain

Koji Ueno, Toshihisa Anzai, Masahiro Jinzaki, Minoru Yamada, Takashi Kohno, Akio Kawamura, Tsutomu Yoshikawa, Sachio Kuribayashi, Satoshi Ogawa

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background/Aims: Early evaluations of patients presenting with acute chest pain remain difficult. We examined the diagnostic capacity of multidetector computed tomography (MDCT) for acute coronary syndrome (ACS) in patients presenting with acute chest pain. Methods/Results: We examined 36 consecutive patients presenting with acute chest pain with neither diagnostic ECG changes nor elevated biomarkers. 64-slice MDCT was performed, and we evaluated the presenceof significant coronaryartery stenosis (>50% reduction in lumen diameter). Significant stenosis was detected in 15 patients by MDCT. Among them, 11 patients were diagnosed as having ACS based on the findings of coronary angiography or myocardial perfusion single photon emission computed tomography (positive predictive value 73%). All 21 patients without significant stenosis by MDCT, except only one, were regarded as not having ACS (negative predictive value 95%). Sensitivity and specificity were 92 and 83%, respectively. In patients without a history of coronary artery disease (CAD), both the specificity and positive predictive value improved to 100% (sensitivity 90%; negative predictive value 95%). In patients with neither a history of CAD nor coronary calcification, the diagnostic accuracy of MDCT was 100%. Conclusions: MDCT has high diagnostic capacity for the early evaluation of ACS, especially in patients without a history of CAD or coronary calcification.

Original languageEnglish
Pages (from-to)211-218
Number of pages8
JournalCardiology
Volume112
Issue number3
DOIs
Publication statusPublished - 2009 Jan

Fingerprint

Multidetector Computed Tomography
Acute Pain
Acute Coronary Syndrome
Chest Pain
Coronary Artery Disease
Pathologic Constriction
Single-Photon Emission-Computed Tomography
Coronary Angiography
Electrocardiography
Perfusion
Biomarkers
Sensitivity and Specificity

Keywords

  • Acute coronary syndrome
  • Chest pain
  • Multidetector computed tomography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)

Cite this

Diagnostic capacity of 64-slice multidetector computed tomography for acute coronary syndrome in patients presenting with acute chest pain. / Ueno, Koji; Anzai, Toshihisa; Jinzaki, Masahiro; Yamada, Minoru; Kohno, Takashi; Kawamura, Akio; Yoshikawa, Tsutomu; Kuribayashi, Sachio; Ogawa, Satoshi.

In: Cardiology, Vol. 112, No. 3, 01.2009, p. 211-218.

Research output: Contribution to journalArticle

Ueno, K, Anzai, T, Jinzaki, M, Yamada, M, Kohno, T, Kawamura, A, Yoshikawa, T, Kuribayashi, S & Ogawa, S 2009, 'Diagnostic capacity of 64-slice multidetector computed tomography for acute coronary syndrome in patients presenting with acute chest pain', Cardiology, vol. 112, no. 3, pp. 211-218. https://doi.org/10.1159/000149630
Ueno, Koji ; Anzai, Toshihisa ; Jinzaki, Masahiro ; Yamada, Minoru ; Kohno, Takashi ; Kawamura, Akio ; Yoshikawa, Tsutomu ; Kuribayashi, Sachio ; Ogawa, Satoshi. / Diagnostic capacity of 64-slice multidetector computed tomography for acute coronary syndrome in patients presenting with acute chest pain. In: Cardiology. 2009 ; Vol. 112, No. 3. pp. 211-218.
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