Diagnostic implications of elevated levels of smooth-muscle myosin heavy-chain protein in acute aortic dissection: The smooth muscle myosin heavy chain study

T. Suzuki, H. Katoh, Y. Tsuchio, A. Hasegawa, M. Kurabayashi, A. Ohira, K. Hiramori, Y. Sakomura, H. Kasanuki, S. Hori, N. Aikawa, S. Abe, C. Tei, Y. Nakagawa, M. Nobuyoshi, K. Misu, T. Sumiyoshi, R. Nagai

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Abstract

Background: A rapid 30-minute assay of circulating smoothmuscle myosin heavy-chain protein has been developed as a biochemical diagnostic tool for aortic dissection. Objective: To determine the sensitivity and specificity of this assay. Design: Cross-sectional study. Setting: 8 major cardiovascular centers in Japan. Patients: 95 patients with acute aortic dissection, 48 patients with acute myocardial infarction, and 131 healthy volunteers. Measurements: Levels of circulating smooth-muscle myosin heavy-chain protein. Results: Patients with acute aortic dissection who presented within 3 hours after onset had elevated levels of circulating smooth-muscle myosin heavy-chain protein. In these patients, the assay had a sensitivity of 90.9%, a specificity of 98% compared with healthy volunteers, and a specificity of 83% compared with patients who had acute myocardial infarction; the clinical decision limit was 2.5 μg/L. All patients with proximal lesions had elevated levels of smooth-muscle myosin heavy-chain protein, and only patients with distal lesions had decreased levels (< 2.5 μg/L). Conclusions: Levels of smooth-muscle myosin heavy-chain protein can be used to diagnose aortic dissection soon after symptom onset. The assay had the greatest diagnostic value in patients with proximal lesions.

Original languageEnglish
Pages (from-to)537-541
Number of pages5
JournalAnnals of internal medicine
Volume133
Issue number7
DOIs
Publication statusPublished - 2000 Oct 3

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ASJC Scopus subject areas

  • Internal Medicine

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Suzuki, T., Katoh, H., Tsuchio, Y., Hasegawa, A., Kurabayashi, M., Ohira, A., Hiramori, K., Sakomura, Y., Kasanuki, H., Hori, S., Aikawa, N., Abe, S., Tei, C., Nakagawa, Y., Nobuyoshi, M., Misu, K., Sumiyoshi, T., & Nagai, R. (2000). Diagnostic implications of elevated levels of smooth-muscle myosin heavy-chain protein in acute aortic dissection: The smooth muscle myosin heavy chain study. Annals of internal medicine, 133(7), 537-541. https://doi.org/10.7326/0003-4819-133-7-200010030-00013