Diagnostic performance of percutaneous core needle lung biopsy under multi-CT fluoroscopic guidance for ground-glass opacity pulmonary lesions

Yoshikane Yamauchi, Yotaro Izumi, Seishi Nakatsuka, Masanori Inoue, Yuichiro Hayashi, Makio Mukai, Hiroaki Nomori

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Objective: The diagnostic performance of percutaneous core needle lung biopsy under multi-CT fluoroscopic guidance for ground-glass opacity (GGO) pulmonary lesions was evaluated. Materials and methods: Out of 90 patients who underwent CT fluoroscopy-guided core needle biopsy of GGO lesions at our institution, the biopsy results and the final diagnoses were retrospectively compared in 67 patients with available data (one lesion per patient). Diagnostic performance was also compared according to the lesion size (≤10 mm (n = 8) versus 11-20 mm (n = 42) versus >20 mm (n = 17)), the percentage of GGO component (50-90% (n = 31) versus >90% (n = 36)), and the length of needle path (≤7 cm (n = 45) versus >7 cm (n = 22)). Finally, all 90 cases were reviewed for complications. Results: The overall sensitivity, specificity, and accuracy were 97%, 100%, and 97%, respectively. The diagnostic sensitivity and accuracy tended to be lower in smaller lesions (≤10 mm; 86 and 88%, 11-20 mm; 97 and 98%, >20 mm; 100 and 100%, respectively, p > 0.05), and in lesions with lower percentage of GGO component (50-90%; 93 and 94%, >90%; 100 and 100%, respectively, p = 0.21), but statistical significances were not reached. The sensitivity and accuracy were not significantly affected by the length of needle path (≤7 cm; 98 and 98%, >7 cm; 95 and 96%, respectively, p = 1.00). Fourteen patients (16%) developed pneumothoraces, and 13 patients (14%) experienced mild hemoptysis, all of which resolved conservatively. Conclusion: The diagnostic performance was satisfactory, and it was considered that the procedure was appropriate for GGO lesions regardless of lesion size, the percentage of GGO component, or the length of needle path. The procedure was also feasible without any major complications.

Original languageEnglish
JournalEuropean Journal of Radiology
Volume79
Issue number2
DOIs
Publication statusPublished - 2011 Aug

Fingerprint

Large-Core Needle Biopsy
Glass
Lung
Needles
Hemoptysis
Fluoroscopy
Pneumothorax
Biopsy
Sensitivity and Specificity

Keywords

  • Ground-glass opacity
  • Lung biopsy
  • Lung cancer

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Diagnostic performance of percutaneous core needle lung biopsy under multi-CT fluoroscopic guidance for ground-glass opacity pulmonary lesions. / Yamauchi, Yoshikane; Izumi, Yotaro; Nakatsuka, Seishi; Inoue, Masanori; Hayashi, Yuichiro; Mukai, Makio; Nomori, Hiroaki.

In: European Journal of Radiology, Vol. 79, No. 2, 08.2011.

Research output: Contribution to journalArticle

@article{dc6ed395abd24d118b4f113f55209bff,
title = "Diagnostic performance of percutaneous core needle lung biopsy under multi-CT fluoroscopic guidance for ground-glass opacity pulmonary lesions",
abstract = "Objective: The diagnostic performance of percutaneous core needle lung biopsy under multi-CT fluoroscopic guidance for ground-glass opacity (GGO) pulmonary lesions was evaluated. Materials and methods: Out of 90 patients who underwent CT fluoroscopy-guided core needle biopsy of GGO lesions at our institution, the biopsy results and the final diagnoses were retrospectively compared in 67 patients with available data (one lesion per patient). Diagnostic performance was also compared according to the lesion size (≤10 mm (n = 8) versus 11-20 mm (n = 42) versus >20 mm (n = 17)), the percentage of GGO component (50-90{\%} (n = 31) versus >90{\%} (n = 36)), and the length of needle path (≤7 cm (n = 45) versus >7 cm (n = 22)). Finally, all 90 cases were reviewed for complications. Results: The overall sensitivity, specificity, and accuracy were 97{\%}, 100{\%}, and 97{\%}, respectively. The diagnostic sensitivity and accuracy tended to be lower in smaller lesions (≤10 mm; 86 and 88{\%}, 11-20 mm; 97 and 98{\%}, >20 mm; 100 and 100{\%}, respectively, p > 0.05), and in lesions with lower percentage of GGO component (50-90{\%}; 93 and 94{\%}, >90{\%}; 100 and 100{\%}, respectively, p = 0.21), but statistical significances were not reached. The sensitivity and accuracy were not significantly affected by the length of needle path (≤7 cm; 98 and 98{\%}, >7 cm; 95 and 96{\%}, respectively, p = 1.00). Fourteen patients (16{\%}) developed pneumothoraces, and 13 patients (14{\%}) experienced mild hemoptysis, all of which resolved conservatively. Conclusion: The diagnostic performance was satisfactory, and it was considered that the procedure was appropriate for GGO lesions regardless of lesion size, the percentage of GGO component, or the length of needle path. The procedure was also feasible without any major complications.",
keywords = "Ground-glass opacity, Lung biopsy, Lung cancer",
author = "Yoshikane Yamauchi and Yotaro Izumi and Seishi Nakatsuka and Masanori Inoue and Yuichiro Hayashi and Makio Mukai and Hiroaki Nomori",
year = "2011",
month = "8",
doi = "10.1016/j.ejrad.2011.03.088",
language = "English",
volume = "79",
journal = "Journal of Medical Imaging",
issn = "0720-048X",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Diagnostic performance of percutaneous core needle lung biopsy under multi-CT fluoroscopic guidance for ground-glass opacity pulmonary lesions

AU - Yamauchi, Yoshikane

AU - Izumi, Yotaro

AU - Nakatsuka, Seishi

AU - Inoue, Masanori

AU - Hayashi, Yuichiro

AU - Mukai, Makio

AU - Nomori, Hiroaki

PY - 2011/8

Y1 - 2011/8

N2 - Objective: The diagnostic performance of percutaneous core needle lung biopsy under multi-CT fluoroscopic guidance for ground-glass opacity (GGO) pulmonary lesions was evaluated. Materials and methods: Out of 90 patients who underwent CT fluoroscopy-guided core needle biopsy of GGO lesions at our institution, the biopsy results and the final diagnoses were retrospectively compared in 67 patients with available data (one lesion per patient). Diagnostic performance was also compared according to the lesion size (≤10 mm (n = 8) versus 11-20 mm (n = 42) versus >20 mm (n = 17)), the percentage of GGO component (50-90% (n = 31) versus >90% (n = 36)), and the length of needle path (≤7 cm (n = 45) versus >7 cm (n = 22)). Finally, all 90 cases were reviewed for complications. Results: The overall sensitivity, specificity, and accuracy were 97%, 100%, and 97%, respectively. The diagnostic sensitivity and accuracy tended to be lower in smaller lesions (≤10 mm; 86 and 88%, 11-20 mm; 97 and 98%, >20 mm; 100 and 100%, respectively, p > 0.05), and in lesions with lower percentage of GGO component (50-90%; 93 and 94%, >90%; 100 and 100%, respectively, p = 0.21), but statistical significances were not reached. The sensitivity and accuracy were not significantly affected by the length of needle path (≤7 cm; 98 and 98%, >7 cm; 95 and 96%, respectively, p = 1.00). Fourteen patients (16%) developed pneumothoraces, and 13 patients (14%) experienced mild hemoptysis, all of which resolved conservatively. Conclusion: The diagnostic performance was satisfactory, and it was considered that the procedure was appropriate for GGO lesions regardless of lesion size, the percentage of GGO component, or the length of needle path. The procedure was also feasible without any major complications.

AB - Objective: The diagnostic performance of percutaneous core needle lung biopsy under multi-CT fluoroscopic guidance for ground-glass opacity (GGO) pulmonary lesions was evaluated. Materials and methods: Out of 90 patients who underwent CT fluoroscopy-guided core needle biopsy of GGO lesions at our institution, the biopsy results and the final diagnoses were retrospectively compared in 67 patients with available data (one lesion per patient). Diagnostic performance was also compared according to the lesion size (≤10 mm (n = 8) versus 11-20 mm (n = 42) versus >20 mm (n = 17)), the percentage of GGO component (50-90% (n = 31) versus >90% (n = 36)), and the length of needle path (≤7 cm (n = 45) versus >7 cm (n = 22)). Finally, all 90 cases were reviewed for complications. Results: The overall sensitivity, specificity, and accuracy were 97%, 100%, and 97%, respectively. The diagnostic sensitivity and accuracy tended to be lower in smaller lesions (≤10 mm; 86 and 88%, 11-20 mm; 97 and 98%, >20 mm; 100 and 100%, respectively, p > 0.05), and in lesions with lower percentage of GGO component (50-90%; 93 and 94%, >90%; 100 and 100%, respectively, p = 0.21), but statistical significances were not reached. The sensitivity and accuracy were not significantly affected by the length of needle path (≤7 cm; 98 and 98%, >7 cm; 95 and 96%, respectively, p = 1.00). Fourteen patients (16%) developed pneumothoraces, and 13 patients (14%) experienced mild hemoptysis, all of which resolved conservatively. Conclusion: The diagnostic performance was satisfactory, and it was considered that the procedure was appropriate for GGO lesions regardless of lesion size, the percentage of GGO component, or the length of needle path. The procedure was also feasible without any major complications.

KW - Ground-glass opacity

KW - Lung biopsy

KW - Lung cancer

UR - http://www.scopus.com/inward/record.url?scp=80052172269&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80052172269&partnerID=8YFLogxK

U2 - 10.1016/j.ejrad.2011.03.088

DO - 10.1016/j.ejrad.2011.03.088

M3 - Article

C2 - 21515009

AN - SCOPUS:80052172269

VL - 79

JO - Journal of Medical Imaging

JF - Journal of Medical Imaging

SN - 0720-048X

IS - 2

ER -