Diagnostic significance of serum soluble transferrin receptors in various anemic diseases: The first multi-institutional joint study in Japan

Akira Matsuda, Masami Besso, Shigehisa Mori, Tsutomu Takeuchi, Tohru Abe, Yoshihito Yawata, Hiraku Mori, Mitsuhiro Omine, Yuichi Nakamura, Shinpei Furusawa, Teiryo Maeda, Susumu Haginosita, Yoshihei Hirasawa, Eriko Kinugasa, Tadao Akizawa, Naohito Kawakami, Atsuo Nagata, Kunitake Hirashima

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Serum soluble transferrin receptor (sTfR) has been reported to be higher in patients with iron deficiency or with elevated erythropoiesis. In the present study, serum sTfR was measured in various anemic diseases and their clinical significance was examined in a multi-institutional joint study. Serum sTfRs in patients with the following anemic diseases were markedly higher than those in normal healthy adults: non-treated iron deficiency anemia (IDA) (9.13 ± 7.04 mg/l, n = 52, p <0.0001), anemia of chronic disorders (ACD) (3.45 ± 1.38 mg/l, n = 20, p <0.0001), hemolytic anemia (HA) (5.57 ± 3.26 mg/l, n = 17, p <0.0001), and myelodysplastic syndrome (MDS) (4.03 ± 2.83 mg/l, n = 20, p <0.0001). There were significant differences between IDA and ACD (p <0.0001), between aplastic anemia (AA) (1.58 ± 1.26 mg/l, n = 16) and MDS (p <0.001), and between AA and MDS with refractory anemia (MDS-RA) (4.16 ± 3.40 mg/l, n = 9) (p <0.02). In patients with chronic renal failure (CRF), serum sTfR levels and serum sTfR/log serum ferritin ratios (sTfR/F index) were compared in the two classified groups according to Muirhead's criteria, as IDA and non-IDA groups with or without recombinant human erythropoietin (rHuEPO) treatment. Significantly high levels of both serum sTfR (p <0.0001) and the sTfR/F index (p <0.0001) were observed in IDA without rHuEPO treatment. Especially in CRF with rHuEPO treatment, the sTfR/F index showed marked elevation in the IDA group (p <0.0001) compared with serum sTfR (p <0.001), indicating more diagnostic efficacy of the sTfR/F index for CRF with IDA. In conclusion, the serum sTfR concentration is a useful diagnostic tool for discrimination between IDA and ACD, and between AA and MDS-RA, and for the detection of iron deficiency in CRF patients in the Japanese population.

Original languageEnglish
Pages (from-to)225-238
Number of pages14
JournalHaematologia
Volume32
Issue number3
DOIs
Publication statusPublished - 2002
Externally publishedYes

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Transferrin Receptors
Japan
Iron-Deficiency Anemias
Serum
Myelodysplastic Syndromes
Chronic Kidney Failure
Aplastic Anemia
Anemia
Erythropoietin
Iron
Refractory Anemia
Erythropoiesis
Hemolytic Anemia
Ferritins
Therapeutics

Keywords

  • Anemia
  • Anemia of chronic disorders
  • Aplastic anemia
  • Chronic renal failure
  • Iron deficiency anemia
  • Myelodysplastic syndrome
  • Soluble transferrin receptor

ASJC Scopus subject areas

  • Hematology

Cite this

Diagnostic significance of serum soluble transferrin receptors in various anemic diseases : The first multi-institutional joint study in Japan. / Matsuda, Akira; Besso, Masami; Mori, Shigehisa; Takeuchi, Tsutomu; Abe, Tohru; Yawata, Yoshihito; Mori, Hiraku; Omine, Mitsuhiro; Nakamura, Yuichi; Furusawa, Shinpei; Maeda, Teiryo; Haginosita, Susumu; Hirasawa, Yoshihei; Kinugasa, Eriko; Akizawa, Tadao; Kawakami, Naohito; Nagata, Atsuo; Hirashima, Kunitake.

In: Haematologia, Vol. 32, No. 3, 2002, p. 225-238.

Research output: Contribution to journalArticle

Matsuda, A, Besso, M, Mori, S, Takeuchi, T, Abe, T, Yawata, Y, Mori, H, Omine, M, Nakamura, Y, Furusawa, S, Maeda, T, Haginosita, S, Hirasawa, Y, Kinugasa, E, Akizawa, T, Kawakami, N, Nagata, A & Hirashima, K 2002, 'Diagnostic significance of serum soluble transferrin receptors in various anemic diseases: The first multi-institutional joint study in Japan', Haematologia, vol. 32, no. 3, pp. 225-238. https://doi.org/10.1163/15685590260461048
Matsuda, Akira ; Besso, Masami ; Mori, Shigehisa ; Takeuchi, Tsutomu ; Abe, Tohru ; Yawata, Yoshihito ; Mori, Hiraku ; Omine, Mitsuhiro ; Nakamura, Yuichi ; Furusawa, Shinpei ; Maeda, Teiryo ; Haginosita, Susumu ; Hirasawa, Yoshihei ; Kinugasa, Eriko ; Akizawa, Tadao ; Kawakami, Naohito ; Nagata, Atsuo ; Hirashima, Kunitake. / Diagnostic significance of serum soluble transferrin receptors in various anemic diseases : The first multi-institutional joint study in Japan. In: Haematologia. 2002 ; Vol. 32, No. 3. pp. 225-238.
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T1 - Diagnostic significance of serum soluble transferrin receptors in various anemic diseases

T2 - The first multi-institutional joint study in Japan

AU - Matsuda, Akira

AU - Besso, Masami

AU - Mori, Shigehisa

AU - Takeuchi, Tsutomu

AU - Abe, Tohru

AU - Yawata, Yoshihito

AU - Mori, Hiraku

AU - Omine, Mitsuhiro

AU - Nakamura, Yuichi

AU - Furusawa, Shinpei

AU - Maeda, Teiryo

AU - Haginosita, Susumu

AU - Hirasawa, Yoshihei

AU - Kinugasa, Eriko

AU - Akizawa, Tadao

AU - Kawakami, Naohito

AU - Nagata, Atsuo

AU - Hirashima, Kunitake

PY - 2002

Y1 - 2002

N2 - Serum soluble transferrin receptor (sTfR) has been reported to be higher in patients with iron deficiency or with elevated erythropoiesis. In the present study, serum sTfR was measured in various anemic diseases and their clinical significance was examined in a multi-institutional joint study. Serum sTfRs in patients with the following anemic diseases were markedly higher than those in normal healthy adults: non-treated iron deficiency anemia (IDA) (9.13 ± 7.04 mg/l, n = 52, p <0.0001), anemia of chronic disorders (ACD) (3.45 ± 1.38 mg/l, n = 20, p <0.0001), hemolytic anemia (HA) (5.57 ± 3.26 mg/l, n = 17, p <0.0001), and myelodysplastic syndrome (MDS) (4.03 ± 2.83 mg/l, n = 20, p <0.0001). There were significant differences between IDA and ACD (p <0.0001), between aplastic anemia (AA) (1.58 ± 1.26 mg/l, n = 16) and MDS (p <0.001), and between AA and MDS with refractory anemia (MDS-RA) (4.16 ± 3.40 mg/l, n = 9) (p <0.02). In patients with chronic renal failure (CRF), serum sTfR levels and serum sTfR/log serum ferritin ratios (sTfR/F index) were compared in the two classified groups according to Muirhead's criteria, as IDA and non-IDA groups with or without recombinant human erythropoietin (rHuEPO) treatment. Significantly high levels of both serum sTfR (p <0.0001) and the sTfR/F index (p <0.0001) were observed in IDA without rHuEPO treatment. Especially in CRF with rHuEPO treatment, the sTfR/F index showed marked elevation in the IDA group (p <0.0001) compared with serum sTfR (p <0.001), indicating more diagnostic efficacy of the sTfR/F index for CRF with IDA. In conclusion, the serum sTfR concentration is a useful diagnostic tool for discrimination between IDA and ACD, and between AA and MDS-RA, and for the detection of iron deficiency in CRF patients in the Japanese population.

AB - Serum soluble transferrin receptor (sTfR) has been reported to be higher in patients with iron deficiency or with elevated erythropoiesis. In the present study, serum sTfR was measured in various anemic diseases and their clinical significance was examined in a multi-institutional joint study. Serum sTfRs in patients with the following anemic diseases were markedly higher than those in normal healthy adults: non-treated iron deficiency anemia (IDA) (9.13 ± 7.04 mg/l, n = 52, p <0.0001), anemia of chronic disorders (ACD) (3.45 ± 1.38 mg/l, n = 20, p <0.0001), hemolytic anemia (HA) (5.57 ± 3.26 mg/l, n = 17, p <0.0001), and myelodysplastic syndrome (MDS) (4.03 ± 2.83 mg/l, n = 20, p <0.0001). There were significant differences between IDA and ACD (p <0.0001), between aplastic anemia (AA) (1.58 ± 1.26 mg/l, n = 16) and MDS (p <0.001), and between AA and MDS with refractory anemia (MDS-RA) (4.16 ± 3.40 mg/l, n = 9) (p <0.02). In patients with chronic renal failure (CRF), serum sTfR levels and serum sTfR/log serum ferritin ratios (sTfR/F index) were compared in the two classified groups according to Muirhead's criteria, as IDA and non-IDA groups with or without recombinant human erythropoietin (rHuEPO) treatment. Significantly high levels of both serum sTfR (p <0.0001) and the sTfR/F index (p <0.0001) were observed in IDA without rHuEPO treatment. Especially in CRF with rHuEPO treatment, the sTfR/F index showed marked elevation in the IDA group (p <0.0001) compared with serum sTfR (p <0.001), indicating more diagnostic efficacy of the sTfR/F index for CRF with IDA. In conclusion, the serum sTfR concentration is a useful diagnostic tool for discrimination between IDA and ACD, and between AA and MDS-RA, and for the detection of iron deficiency in CRF patients in the Japanese population.

KW - Anemia

KW - Anemia of chronic disorders

KW - Aplastic anemia

KW - Chronic renal failure

KW - Iron deficiency anemia

KW - Myelodysplastic syndrome

KW - Soluble transferrin receptor

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