Diagnostic significance of tumor markers for gynecologic malignancies

Daisuke Aoki, Akira Hirasawa, Nobuyuki Susumu

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Gynecologic malignancies include ovarian cancer, uterine cervical cancer, endometrial cancer, and trophoblastic neoplasms. With ovarian tumors, due to their location within the abdominal cavity, it is difficult to make a preoperative pathological diagnosis of cancer without laparotomy. From this point of view, the use of tumor markers that consist of carbohydrate antigens, such as CA 125, in addition to diagnostic imaging are useful in the diagnosis of ovarian cancer. SCC antigen, a marker for squamous cell carcinoma, is clinically useful in the management of advanced cervical cancer. At present, there are no useful tumor markers for endometrial cancer that exhibit both high sensitivity and specificity, although CA 125 is often used in clinical practice. Finally, human chorionic gonadotropin (hCG) serves as an ideal tumor marker for trophoblastic disease; however, the incidence of trophoblastic neoplasms has decreased dramatically with the incorporation of strict clinical management of post-molar disease as well as with the overall decrease in the number of pregnancies.

Original languageEnglish
Pages (from-to)411-416
Number of pages6
JournalGan to kagaku ryoho. Cancer & chemotherapy
Volume32
Issue number3
Publication statusPublished - 2005 Mar

Fingerprint

Endometrial Neoplasms
Tumor Biomarkers
Trophoblastic Neoplasms
Uterine Cervical Neoplasms
Ovarian Neoplasms
Neoplasms
Abdominal Cavity
Chorionic Gonadotropin
Diagnostic Imaging
Laparotomy
Squamous Cell Carcinoma
Carbohydrates
Antigens
Sensitivity and Specificity
Pregnancy
Incidence

ASJC Scopus subject areas

  • Cancer Research
  • Pharmacology

Cite this

Diagnostic significance of tumor markers for gynecologic malignancies. / Aoki, Daisuke; Hirasawa, Akira; Susumu, Nobuyuki.

In: Gan to kagaku ryoho. Cancer & chemotherapy, Vol. 32, No. 3, 03.2005, p. 411-416.

Research output: Contribution to journalArticle

Aoki, Daisuke ; Hirasawa, Akira ; Susumu, Nobuyuki. / Diagnostic significance of tumor markers for gynecologic malignancies. In: Gan to kagaku ryoho. Cancer & chemotherapy. 2005 ; Vol. 32, No. 3. pp. 411-416.
@article{b8da4357ba8b49da92f1663946ebfb02,
title = "Diagnostic significance of tumor markers for gynecologic malignancies",
abstract = "Gynecologic malignancies include ovarian cancer, uterine cervical cancer, endometrial cancer, and trophoblastic neoplasms. With ovarian tumors, due to their location within the abdominal cavity, it is difficult to make a preoperative pathological diagnosis of cancer without laparotomy. From this point of view, the use of tumor markers that consist of carbohydrate antigens, such as CA 125, in addition to diagnostic imaging are useful in the diagnosis of ovarian cancer. SCC antigen, a marker for squamous cell carcinoma, is clinically useful in the management of advanced cervical cancer. At present, there are no useful tumor markers for endometrial cancer that exhibit both high sensitivity and specificity, although CA 125 is often used in clinical practice. Finally, human chorionic gonadotropin (hCG) serves as an ideal tumor marker for trophoblastic disease; however, the incidence of trophoblastic neoplasms has decreased dramatically with the incorporation of strict clinical management of post-molar disease as well as with the overall decrease in the number of pregnancies.",
author = "Daisuke Aoki and Akira Hirasawa and Nobuyuki Susumu",
year = "2005",
month = "3",
language = "English",
volume = "32",
pages = "411--416",
journal = "Japanese Journal of Cancer and Chemotherapy",
issn = "0385-0684",
publisher = "Japanese Journal of Cancer and Chemotherapy Publishers Inc.",
number = "3",

}

TY - JOUR

T1 - Diagnostic significance of tumor markers for gynecologic malignancies

AU - Aoki, Daisuke

AU - Hirasawa, Akira

AU - Susumu, Nobuyuki

PY - 2005/3

Y1 - 2005/3

N2 - Gynecologic malignancies include ovarian cancer, uterine cervical cancer, endometrial cancer, and trophoblastic neoplasms. With ovarian tumors, due to their location within the abdominal cavity, it is difficult to make a preoperative pathological diagnosis of cancer without laparotomy. From this point of view, the use of tumor markers that consist of carbohydrate antigens, such as CA 125, in addition to diagnostic imaging are useful in the diagnosis of ovarian cancer. SCC antigen, a marker for squamous cell carcinoma, is clinically useful in the management of advanced cervical cancer. At present, there are no useful tumor markers for endometrial cancer that exhibit both high sensitivity and specificity, although CA 125 is often used in clinical practice. Finally, human chorionic gonadotropin (hCG) serves as an ideal tumor marker for trophoblastic disease; however, the incidence of trophoblastic neoplasms has decreased dramatically with the incorporation of strict clinical management of post-molar disease as well as with the overall decrease in the number of pregnancies.

AB - Gynecologic malignancies include ovarian cancer, uterine cervical cancer, endometrial cancer, and trophoblastic neoplasms. With ovarian tumors, due to their location within the abdominal cavity, it is difficult to make a preoperative pathological diagnosis of cancer without laparotomy. From this point of view, the use of tumor markers that consist of carbohydrate antigens, such as CA 125, in addition to diagnostic imaging are useful in the diagnosis of ovarian cancer. SCC antigen, a marker for squamous cell carcinoma, is clinically useful in the management of advanced cervical cancer. At present, there are no useful tumor markers for endometrial cancer that exhibit both high sensitivity and specificity, although CA 125 is often used in clinical practice. Finally, human chorionic gonadotropin (hCG) serves as an ideal tumor marker for trophoblastic disease; however, the incidence of trophoblastic neoplasms has decreased dramatically with the incorporation of strict clinical management of post-molar disease as well as with the overall decrease in the number of pregnancies.

UR - http://www.scopus.com/inward/record.url?scp=15544380004&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=15544380004&partnerID=8YFLogxK

M3 - Article

C2 - 15791829

AN - SCOPUS:15544380004

VL - 32

SP - 411

EP - 416

JO - Japanese Journal of Cancer and Chemotherapy

JF - Japanese Journal of Cancer and Chemotherapy

SN - 0385-0684

IS - 3

ER -