Diagnostic value of FDG PET and salivary gland scintigraphy for parotid tumors

Yoshitaka Uchida, Satoshi Minoshima, Tetsuya Kawata, Ken Motoori, Koichi Nakano, Toshiki Kazama, Takashi Uno, Yoshitaka Okamoto, Hisao Ito

Research output: Contribution to journalArticle

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Abstract

Purpose: The purpose of this study was to examine the diagnostic value of the combination of F-18 fluorodeoxyglucose (FDG) PET and Tc-99m pertechnetate salivary gland scintigraphy in parotid tumors. Materials and Methods: Seventy-two patients with benign parotid gland tumors (n = 52), malignant parotid tumors (n = 12), and inflammation (n = 8) underwent both FDG PET and salivary gland scintigraphy within 1 week, and 66 of the patients also underwent gallium scintigraphy. All patients were negative on their first fine-needle aspiration (FNA). Results: Malignant parotid tumors showed significantly higher FDG uptake (standard uptake values [SUVs]) than both benign tumors and inflammation, except in Warthin's tumor (5.82 ± 3.95 vs. 2.07 ± 1.33; P <0.01). Although the SUV values of Warthin's tumor and malignant parotid tumors overlapped somewhat, Warthin's tumor did demonstrate increased radiotracer uptake, and it was reliably distinguished from other parotid gland tumors by the use of salivary gland scintigraphy. Considering a SUV value >3 as being positive for malignancy and excluding Warthin's tumor on the basis of salivary gland scintigraphy, sensitivity and specificity of FDG PET were 75% and 80%, respectively. These results were superior to those of gallium scintigraphy (58% and 72%, respectively). Conclusions: Although the diagnostic value of FDG PET in the differentiation of malignant from benign parotid gland tumors was limited because of the high FDG uptake in some benign tumors, and particularly pleomorphic adenomas, combining salivary gland scintigraphy with FDG PET may help to negate this drawback, and this combination may be a more promising approach for differentiation of various parotid gland tumors in patients compared with nondiagnostic needle aspiration.

Original languageEnglish
Pages (from-to)170-176
Number of pages7
JournalClinical Nuclear Medicine
Volume30
Issue number3
DOIs
Publication statusPublished - 2005 Mar
Externally publishedYes

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Salivary Glands
Radionuclide Imaging
Neoplasms
Parotid Gland
Adenolymphoma
Gallium
Inflammation
Sodium Pertechnetate Tc 99m
Fluorodeoxyglucose F18
Fine Needle Biopsy
Needles
Sensitivity and Specificity

Keywords

  • Diagnosis
  • F-18 FDG PET
  • Parotid tumor
  • Salivary grand scintigraphy
  • Sensitivity

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Uchida, Y., Minoshima, S., Kawata, T., Motoori, K., Nakano, K., Kazama, T., ... Ito, H. (2005). Diagnostic value of FDG PET and salivary gland scintigraphy for parotid tumors. Clinical Nuclear Medicine, 30(3), 170-176. https://doi.org/10.1097/00003072-200503000-00005

Diagnostic value of FDG PET and salivary gland scintigraphy for parotid tumors. / Uchida, Yoshitaka; Minoshima, Satoshi; Kawata, Tetsuya; Motoori, Ken; Nakano, Koichi; Kazama, Toshiki; Uno, Takashi; Okamoto, Yoshitaka; Ito, Hisao.

In: Clinical Nuclear Medicine, Vol. 30, No. 3, 03.2005, p. 170-176.

Research output: Contribution to journalArticle

Uchida, Y, Minoshima, S, Kawata, T, Motoori, K, Nakano, K, Kazama, T, Uno, T, Okamoto, Y & Ito, H 2005, 'Diagnostic value of FDG PET and salivary gland scintigraphy for parotid tumors', Clinical Nuclear Medicine, vol. 30, no. 3, pp. 170-176. https://doi.org/10.1097/00003072-200503000-00005
Uchida, Yoshitaka ; Minoshima, Satoshi ; Kawata, Tetsuya ; Motoori, Ken ; Nakano, Koichi ; Kazama, Toshiki ; Uno, Takashi ; Okamoto, Yoshitaka ; Ito, Hisao. / Diagnostic value of FDG PET and salivary gland scintigraphy for parotid tumors. In: Clinical Nuclear Medicine. 2005 ; Vol. 30, No. 3. pp. 170-176.
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