Diagnostic value of intestinal fatty acid-binding protein for pneumatosis intestinalis

Shokei Matsumoto, Kazuhiko Sekine, Hiroyuki Funaoka, Tomohiro Funabiki, Motoyasu Yamazaki, Tomohiko Orita, Kei Hayashida, Mitsuhide Kitano

Research output: Contribution to journalArticle

4 Citations (Scopus)


Background Pneumatosis intestinalis (PI) is known as a sign of a life-threatening bowel ischemia. We aimed to evaluate the utility of intestinal fatty acid-binding protein (I-FABP) in the diagnosis of pathologic PI. Methods All consecutive patients who presented to our emergency department with PI were prospectively enrolled. The diagnostic performance of I-FABP for pathologic PI was compared with that of other traditional biomarkers and various parameters. Results Seventy patients with PI were enrolled. Pathologic PI was diagnosed in 27 patients (39%). The levels of most biomarkers were significantly higher in patients with pathologic PI than those with nonpathologic PI (P <.05). Receiver operator characteristic analysis revealed that the area under the curve (AUC) was highest for I-FABP (area under the curve =.82) in the diagnosis of pathologic PI. Conclusions High I-FABP value, in combination with other parameters, might be clinically useful for pathologic PI.

Original languageEnglish
Pages (from-to)961-968
Number of pages8
JournalAmerican Journal of Surgery
Issue number5
Publication statusPublished - 2016 Nov 1
Externally publishedYes



  • Biomarkers
  • Diagnosis
  • Intestinal fatty acid-binding protein
  • Ischemia
  • Pneumatosis intestinalis

ASJC Scopus subject areas

  • Surgery

Cite this

Matsumoto, S., Sekine, K., Funaoka, H., Funabiki, T., Yamazaki, M., Orita, T., Hayashida, K., & Kitano, M. (2016). Diagnostic value of intestinal fatty acid-binding protein for pneumatosis intestinalis. American Journal of Surgery, 212(5), 961-968. https://doi.org/10.1016/j.amjsurg.2016.04.002