Diagnostic value of intestinal fatty acid-binding protein for pneumatosis intestinalis

Shokei Matsumoto, Kazuhiko Sekine, Hiroyuki Funaoka, Tomohiro Funabiki, Motoyasu Yamazaki, Tomohiko Orita, Kei Hayashida, Mitsuhide Kitano

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background Pneumatosis intestinalis (PI) is known as a sign of a life-threatening bowel ischemia. We aimed to evaluate the utility of intestinal fatty acid-binding protein (I-FABP) in the diagnosis of pathologic PI. Methods All consecutive patients who presented to our emergency department with PI were prospectively enrolled. The diagnostic performance of I-FABP for pathologic PI was compared with that of other traditional biomarkers and various parameters. Results Seventy patients with PI were enrolled. Pathologic PI was diagnosed in 27 patients (39%). The levels of most biomarkers were significantly higher in patients with pathologic PI than those with nonpathologic PI (P <.05). Receiver operator characteristic analysis revealed that the area under the curve (AUC) was highest for I-FABP (area under the curve =.82) in the diagnosis of pathologic PI. Conclusions High I-FABP value, in combination with other parameters, might be clinically useful for pathologic PI.

Original languageEnglish
Pages (from-to)961-968
Number of pages8
JournalAmerican Journal of Surgery
Volume212
Issue number5
DOIs
Publication statusPublished - 2016 Nov 1
Externally publishedYes

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Fatty Acid-Binding Proteins
Area Under Curve
Biomarkers
Hospital Emergency Service
Ischemia

Keywords

  • Biomarkers
  • Diagnosis
  • Intestinal fatty acid-binding protein
  • Ischemia
  • Pneumatosis intestinalis

ASJC Scopus subject areas

  • Surgery

Cite this

Matsumoto, S., Sekine, K., Funaoka, H., Funabiki, T., Yamazaki, M., Orita, T., ... Kitano, M. (2016). Diagnostic value of intestinal fatty acid-binding protein for pneumatosis intestinalis. American Journal of Surgery, 212(5), 961-968. https://doi.org/10.1016/j.amjsurg.2016.04.002

Diagnostic value of intestinal fatty acid-binding protein for pneumatosis intestinalis. / Matsumoto, Shokei; Sekine, Kazuhiko; Funaoka, Hiroyuki; Funabiki, Tomohiro; Yamazaki, Motoyasu; Orita, Tomohiko; Hayashida, Kei; Kitano, Mitsuhide.

In: American Journal of Surgery, Vol. 212, No. 5, 01.11.2016, p. 961-968.

Research output: Contribution to journalArticle

Matsumoto, S, Sekine, K, Funaoka, H, Funabiki, T, Yamazaki, M, Orita, T, Hayashida, K & Kitano, M 2016, 'Diagnostic value of intestinal fatty acid-binding protein for pneumatosis intestinalis', American Journal of Surgery, vol. 212, no. 5, pp. 961-968. https://doi.org/10.1016/j.amjsurg.2016.04.002
Matsumoto, Shokei ; Sekine, Kazuhiko ; Funaoka, Hiroyuki ; Funabiki, Tomohiro ; Yamazaki, Motoyasu ; Orita, Tomohiko ; Hayashida, Kei ; Kitano, Mitsuhide. / Diagnostic value of intestinal fatty acid-binding protein for pneumatosis intestinalis. In: American Journal of Surgery. 2016 ; Vol. 212, No. 5. pp. 961-968.
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