Diastereoselective Synthesis of CF 3 -Substituted Spiroisochromans by [1,5]-Hydride Shift/Cyclization/Intramolecular Friedel-Crafts Reaction Sequence

Risa Tamura, Eriko Kitamura, Ryosuke Tsutsumi, Masahiro Yamanaka, Takahiko Akiyama, Keiji Mori

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

Developed herein is a diastereoselective synthesis of CF 3 -substituted spiroisochromans via C(sp 3 )-H bond functionalization involving sequential transformations ([1,5]-hydride shift/cyclization/elimination of MeOH/intramolecular Friedel-Crafts reaction).

Original languageEnglish
Pages (from-to)2383-2387
Number of pages5
JournalOrganic Letters
Volume21
Issue number7
DOIs
Publication statusPublished - 2019 Apr 5
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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