Dietary bioflavonoids induce apoptosis in human leukemia cells

Jun Matsui; Nobutaka Kiyokawa; Hisami Takenouchi; Tomoko Taguchi; Kyoko Suzuki; Yusuke Shiozawa; Masahiro Saito; Wei Ran Tang; Yohko U. Katagiri; Hajime Okita; Junichiro Fujimoto

doi:10.1016/j.leukres.2004.11.015

Dietary bioflavonoids induce apoptosis in human leukemia cells

Jun Matsui, Nobutaka Kiyokawa, Hisami Takenouchi, Tomoko Taguchi, Kyoko Suzuki, Yusuke Shiozawa, Masahiro Saito, Wei Ran Tang, Yohko U. Katagiri, Hajime Okita, Junichiro Fujimoto

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Dietary bioflavonoids are secondary metabolites of plants that are known to have a variety of bio-effects, including anti-cancer activity. In this study, we examined the effects of flavonoids on the growth of human leukemia cells and found that certain flavonoids induce apoptosis in a variety of human leukemia cells. The apoptosis induced by bioflavonoids was dose-dependent and was accompanied by a disruption of the mitochondrial transmembrane potential and the activation of caspase. Our data suggests that dietary bioflavonoids may be useful chemotherapeutic reagents for leukemia patients.

Original language	English
Pages (from-to)	573-581
Number of pages	9
Journal	Leukemia Research
Volume	29
Issue number	5
DOIs	https://doi.org/10.1016/j.leukres.2004.11.015
Publication status	Published - 2005 May
Externally published	Yes

Keywords

Acute lymphoblastic leukemia
Apoptosis
Bioflavonoid
Precursor-B-cell

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1016/j.leukres.2004.11.015

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Dietary bioflavonoids induce apoptosis in human leukemia cells. / Matsui, Jun; Kiyokawa, Nobutaka; Takenouchi, Hisami; Taguchi, Tomoko; Suzuki, Kyoko; Shiozawa, Yusuke; Saito, Masahiro; Tang, Wei Ran; Katagiri, Yohko U.; Okita, Hajime; Fujimoto, Junichiro.

In: Leukemia Research, Vol. 29, No. 5, 05.2005, p. 573-581.

Research output: Contribution to journal › Article › peer-review

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title = "Dietary bioflavonoids induce apoptosis in human leukemia cells",

abstract = "Dietary bioflavonoids are secondary metabolites of plants that are known to have a variety of bio-effects, including anti-cancer activity. In this study, we examined the effects of flavonoids on the growth of human leukemia cells and found that certain flavonoids induce apoptosis in a variety of human leukemia cells. The apoptosis induced by bioflavonoids was dose-dependent and was accompanied by a disruption of the mitochondrial transmembrane potential and the activation of caspase. Our data suggests that dietary bioflavonoids may be useful chemotherapeutic reagents for leukemia patients.",

keywords = "Acute lymphoblastic leukemia, Apoptosis, Bioflavonoid, Precursor-B-cell",

author = "Jun Matsui and Nobutaka Kiyokawa and Hisami Takenouchi and Tomoko Taguchi and Kyoko Suzuki and Yusuke Shiozawa and Masahiro Saito and Tang, {Wei Ran} and Katagiri, {Yohko U.} and Hajime Okita and Junichiro Fujimoto",

note = "Funding Information: We thank S. Yamauchi for her excellent secretarial work. We also thank Dr. Y. Matsuo (Hayashibara Biochemical Laboratories Inc.) for gifting the cell lines. This work was supported in part by Health and Labour Sciences Research Grants from the Ministry of Health, Labour and Welfare of Japan, MEXT. KAKENHI 15019129, JSPS. KAKENHI 15390133 and 15590361, grant from the Japan Health Sciences Foundation for Research on Health Sciences Focusing on Drug Innovation, a grant from Sankyo Foundation of Life Science. ",

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AU - Matsui, Jun

AU - Kiyokawa, Nobutaka

AU - Takenouchi, Hisami

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AU - Shiozawa, Yusuke

AU - Saito, Masahiro

AU - Tang, Wei Ran

AU - Katagiri, Yohko U.

AU - Okita, Hajime

AU - Fujimoto, Junichiro

N1 - Funding Information: We thank S. Yamauchi for her excellent secretarial work. We also thank Dr. Y. Matsuo (Hayashibara Biochemical Laboratories Inc.) for gifting the cell lines. This work was supported in part by Health and Labour Sciences Research Grants from the Ministry of Health, Labour and Welfare of Japan, MEXT. KAKENHI 15019129, JSPS. KAKENHI 15390133 and 15590361, grant from the Japan Health Sciences Foundation for Research on Health Sciences Focusing on Drug Innovation, a grant from Sankyo Foundation of Life Science.

PY - 2005/5

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N2 - Dietary bioflavonoids are secondary metabolites of plants that are known to have a variety of bio-effects, including anti-cancer activity. In this study, we examined the effects of flavonoids on the growth of human leukemia cells and found that certain flavonoids induce apoptosis in a variety of human leukemia cells. The apoptosis induced by bioflavonoids was dose-dependent and was accompanied by a disruption of the mitochondrial transmembrane potential and the activation of caspase. Our data suggests that dietary bioflavonoids may be useful chemotherapeutic reagents for leukemia patients.

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KW - Acute lymphoblastic leukemia

KW - Apoptosis

KW - Bioflavonoid

KW - Precursor-B-cell

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Dietary bioflavonoids induce apoptosis in human leukemia cells

Abstract

Keywords

ASJC Scopus subject areas

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