Dietary bioflavonoids induce apoptosis in human leukemia cells

Jun Matsui, Nobutaka Kiyokawa, Hisami Takenouchi, Tomoko Taguchi, Kyoko Suzuki, Yusuke Shiozawa, Masahiro Saito, Wei Ran Tang, Yohko U. Katagiri, Hajime Okita, Junichiro Fujimoto

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26 Citations (Scopus)

Abstract

Dietary bioflavonoids are secondary metabolites of plants that are known to have a variety of bio-effects, including anti-cancer activity. In this study, we examined the effects of flavonoids on the growth of human leukemia cells and found that certain flavonoids induce apoptosis in a variety of human leukemia cells. The apoptosis induced by bioflavonoids was dose-dependent and was accompanied by a disruption of the mitochondrial transmembrane potential and the activation of caspase. Our data suggests that dietary bioflavonoids may be useful chemotherapeutic reagents for leukemia patients.

Original languageEnglish
Pages (from-to)573-581
Number of pages9
JournalLeukemia Research
Volume29
Issue number5
DOIs
Publication statusPublished - 2005 May
Externally publishedYes

Keywords

  • Acute lymphoblastic leukemia
  • Apoptosis
  • Bioflavonoid
  • Precursor-B-cell

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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  • Cite this

    Matsui, J., Kiyokawa, N., Takenouchi, H., Taguchi, T., Suzuki, K., Shiozawa, Y., Saito, M., Tang, W. R., Katagiri, Y. U., Okita, H., & Fujimoto, J. (2005). Dietary bioflavonoids induce apoptosis in human leukemia cells. Leukemia Research, 29(5), 573-581. https://doi.org/10.1016/j.leukres.2004.11.015