Abstract
Dietary bioflavonoids are secondary metabolites of plants that are known to have a variety of bio-effects, including anti-cancer activity. In this study, we examined the effects of flavonoids on the growth of human leukemia cells and found that certain flavonoids induce apoptosis in a variety of human leukemia cells. The apoptosis induced by bioflavonoids was dose-dependent and was accompanied by a disruption of the mitochondrial transmembrane potential and the activation of caspase. Our data suggests that dietary bioflavonoids may be useful chemotherapeutic reagents for leukemia patients.
Original language | English |
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Pages (from-to) | 573-581 |
Number of pages | 9 |
Journal | Leukemia Research |
Volume | 29 |
Issue number | 5 |
DOIs | |
Publication status | Published - 2005 May |
Externally published | Yes |
Keywords
- Acute lymphoblastic leukemia
- Apoptosis
- Bioflavonoid
- Precursor-B-cell
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research