Dietary bioflavonoids induce apoptosis in human leukemia cells

Jun Matsui; Nobutaka Kiyokawa; Hisami Takenouchi; Tomoko Taguchi; Kyoko Suzuki; Yusuke Shiozawa; Masahiro Saito; Wei Ran Tang; Yohko U. Katagiri; Hajime Okita; Junichiro Fujimoto

doi:10.1016/j.leukres.2004.11.015

Dietary bioflavonoids induce apoptosis in human leukemia cells

Jun Matsui, Nobutaka Kiyokawa, Hisami Takenouchi, Tomoko Taguchi, Kyoko Suzuki, Yusuke Shiozawa, Masahiro Saito, Wei Ran Tang, Yohko U. Katagiri, Hajime Okita, Junichiro Fujimoto

Research output: Contribution to journal › Article

26 Citations (Scopus)

Abstract

Dietary bioflavonoids are secondary metabolites of plants that are known to have a variety of bio-effects, including anti-cancer activity. In this study, we examined the effects of flavonoids on the growth of human leukemia cells and found that certain flavonoids induce apoptosis in a variety of human leukemia cells. The apoptosis induced by bioflavonoids was dose-dependent and was accompanied by a disruption of the mitochondrial transmembrane potential and the activation of caspase. Our data suggests that dietary bioflavonoids may be useful chemotherapeutic reagents for leukemia patients.

Original language	English
Pages (from-to)	573-581
Number of pages	9
Journal	Leukemia Research
Volume	29
Issue number	5
DOIs	https://doi.org/10.1016/j.leukres.2004.11.015
Publication status	Published - 2005 May
Externally published	Yes

Keywords

Acute lymphoblastic leukemia
Apoptosis
Bioflavonoid
Precursor-B-cell

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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Matsui, J., Kiyokawa, N., Takenouchi, H., Taguchi, T., Suzuki, K., Shiozawa, Y., Saito, M., Tang, W. R., Katagiri, Y. U., Okita, H., & Fujimoto, J. (2005). Dietary bioflavonoids induce apoptosis in human leukemia cells. Leukemia Research, 29(5), 573-581. https://doi.org/10.1016/j.leukres.2004.11.015

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abstract = "Dietary bioflavonoids are secondary metabolites of plants that are known to have a variety of bio-effects, including anti-cancer activity. In this study, we examined the effects of flavonoids on the growth of human leukemia cells and found that certain flavonoids induce apoptosis in a variety of human leukemia cells. The apoptosis induced by bioflavonoids was dose-dependent and was accompanied by a disruption of the mitochondrial transmembrane potential and the activation of caspase. Our data suggests that dietary bioflavonoids may be useful chemotherapeutic reagents for leukemia patients.",

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author = "Jun Matsui and Nobutaka Kiyokawa and Hisami Takenouchi and Tomoko Taguchi and Kyoko Suzuki and Yusuke Shiozawa and Masahiro Saito and Tang, {Wei Ran} and Katagiri, {Yohko U.} and Hajime Okita and Junichiro Fujimoto",

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AU - Matsui, Jun

AU - Kiyokawa, Nobutaka

AU - Takenouchi, Hisami

AU - Taguchi, Tomoko

AU - Suzuki, Kyoko

AU - Shiozawa, Yusuke

AU - Saito, Masahiro

AU - Tang, Wei Ran

AU - Katagiri, Yohko U.

AU - Okita, Hajime

AU - Fujimoto, Junichiro

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KW - Apoptosis

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KW - Precursor-B-cell

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