Abstract
Dietary bioflavonoids are secondary metabolites of plants that are known to have a variety of bio-effects, including anti-cancer activity. In this study, we examined the effects of flavonoids on the growth of human leukemia cells and found that certain flavonoids induce apoptosis in a variety of human leukemia cells. The apoptosis induced by bioflavonoids was dose-dependent and was accompanied by a disruption of the mitochondrial transmembrane potential and the activation of caspase. Our data suggests that dietary bioflavonoids may be useful chemotherapeutic reagents for leukemia patients.
| Original language | English |
|---|---|
| Pages (from-to) | 573-581 |
| Number of pages | 9 |
| Journal | Leukemia Research |
| Volume | 29 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2005 May |
| Externally published | Yes |
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Keywords
- Acute lymphoblastic leukemia
- Apoptosis
- Bioflavonoid
- Precursor-B-cell
ASJC Scopus subject areas
- Cancer Research
- Hematology
- Oncology
Cite this
Dietary bioflavonoids induce apoptosis in human leukemia cells. / Matsui, Jun; Kiyokawa, Nobutaka; Takenouchi, Hisami; Taguchi, Tomoko; Suzuki, Kyoko; Shiozawa, Yusuke; Saito, Masahiro; Tang, Wei Ran; Katagiri, Yohko U.; Okita, Hajime; Fujimoto, Junichiro.
In: Leukemia Research, Vol. 29, No. 5, 05.2005, p. 573-581.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Dietary bioflavonoids induce apoptosis in human leukemia cells
AU - Matsui, Jun
AU - Kiyokawa, Nobutaka
AU - Takenouchi, Hisami
AU - Taguchi, Tomoko
AU - Suzuki, Kyoko
AU - Shiozawa, Yusuke
AU - Saito, Masahiro
AU - Tang, Wei Ran
AU - Katagiri, Yohko U.
AU - Okita, Hajime
AU - Fujimoto, Junichiro
PY - 2005/5
Y1 - 2005/5
N2 - Dietary bioflavonoids are secondary metabolites of plants that are known to have a variety of bio-effects, including anti-cancer activity. In this study, we examined the effects of flavonoids on the growth of human leukemia cells and found that certain flavonoids induce apoptosis in a variety of human leukemia cells. The apoptosis induced by bioflavonoids was dose-dependent and was accompanied by a disruption of the mitochondrial transmembrane potential and the activation of caspase. Our data suggests that dietary bioflavonoids may be useful chemotherapeutic reagents for leukemia patients.
AB - Dietary bioflavonoids are secondary metabolites of plants that are known to have a variety of bio-effects, including anti-cancer activity. In this study, we examined the effects of flavonoids on the growth of human leukemia cells and found that certain flavonoids induce apoptosis in a variety of human leukemia cells. The apoptosis induced by bioflavonoids was dose-dependent and was accompanied by a disruption of the mitochondrial transmembrane potential and the activation of caspase. Our data suggests that dietary bioflavonoids may be useful chemotherapeutic reagents for leukemia patients.
KW - Acute lymphoblastic leukemia
KW - Apoptosis
KW - Bioflavonoid
KW - Precursor-B-cell
UR - http://www.scopus.com/inward/record.url?scp=20044394164&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=20044394164&partnerID=8YFLogxK
U2 - 10.1016/j.leukres.2004.11.015
DO - 10.1016/j.leukres.2004.11.015
M3 - Article
C2 - 15755510
AN - SCOPUS:20044394164
VL - 29
SP - 573
EP - 581
JO - Leukemia Research
JF - Leukemia Research
SN - 0145-2126
IS - 5
ER -