Dietary fat attenuates the benefits of an elemental diet in active Crohn's disease: A randomized, controlled trial

Tadao Bamba, Takashi Shimoyama, Masaya Sasaki, Tomoyuki Tsujikawa, Yoshihiro Fukuda, Kazutaka Koganei, Toshifumi Hibi, Yasushi Iwao, Akihiro Munakata, Shinsaku Fukuda, Takayuki Matsumoto, Nobuhide Oshitani, Nobuo Hiwatashi, Tatsuo Oriuchi, Tetsuji Kitahora, Toshinori Utsunomiya, Yasushi Saitoh, Yasuo Suzuki, Mitsuyoshi Nakajima

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Objectives: Although an elemental diet has been established as the primary treatment for patients with Crohn's disease, the influence of dietary fat on the elemental diet remains unclear. We have designed the first randomized, controlled trial for elemental diets containing different fat percentages in patients with active Crohn's disease. Methods: Each patient was randomized to receive one of three dose levels of fat in an elemental diet (Elental) for 4 weeks: 10 patients received low fat (3.06 g/day), 10 patients received medium fat (16.56 g/day) and eight patients received high fat (30.06 g/day). The additional fat was composed of long-chain fatty acids. All patients were evaluated using the International Organization of Inflammatory Bowel Disease rating, plus C-reactive protein level and erythrocyte sedimentation rate, which were measured at weekly intervals. Results: Although the International Organization of Inflammatory Bowel Disease rating, C-reactive protein level and erythrocyte sedimentation rate in the low-fat group decreased, the values in the medium- and high-fat groups fluctuated during the study. The remission rate after 4 weeks in each group was 80%, 40% and 25% for patients in the low-, medium- and high-fat groups, respectively. Conclusions: When the fat consisted of long-chain triglycerides, a high amount of this fat in the elemental diet formula decreased its therapeutic effect against active Crohn's disease.

Original languageEnglish
Pages (from-to)151-157
Number of pages7
JournalEuropean Journal of Gastroenterology and Hepatology
Volume15
Issue number2
DOIs
Publication statusPublished - 2003 Feb 1

Fingerprint

Formulated Food
Dietary Fats
Crohn Disease
Randomized Controlled Trials
Fats
Blood Sedimentation
Inflammatory Bowel Diseases
C-Reactive Protein
Therapeutic Uses
Triglycerides
Fatty Acids

Keywords

  • Crohn's disease
  • Dietary fat
  • Elemental diet
  • International Organization of Inflammatory Bowel Disease

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Dietary fat attenuates the benefits of an elemental diet in active Crohn's disease : A randomized, controlled trial. / Bamba, Tadao; Shimoyama, Takashi; Sasaki, Masaya; Tsujikawa, Tomoyuki; Fukuda, Yoshihiro; Koganei, Kazutaka; Hibi, Toshifumi; Iwao, Yasushi; Munakata, Akihiro; Fukuda, Shinsaku; Matsumoto, Takayuki; Oshitani, Nobuhide; Hiwatashi, Nobuo; Oriuchi, Tatsuo; Kitahora, Tetsuji; Utsunomiya, Toshinori; Saitoh, Yasushi; Suzuki, Yasuo; Nakajima, Mitsuyoshi.

In: European Journal of Gastroenterology and Hepatology, Vol. 15, No. 2, 01.02.2003, p. 151-157.

Research output: Contribution to journalArticle

Bamba, T, Shimoyama, T, Sasaki, M, Tsujikawa, T, Fukuda, Y, Koganei, K, Hibi, T, Iwao, Y, Munakata, A, Fukuda, S, Matsumoto, T, Oshitani, N, Hiwatashi, N, Oriuchi, T, Kitahora, T, Utsunomiya, T, Saitoh, Y, Suzuki, Y & Nakajima, M 2003, 'Dietary fat attenuates the benefits of an elemental diet in active Crohn's disease: A randomized, controlled trial', European Journal of Gastroenterology and Hepatology, vol. 15, no. 2, pp. 151-157. https://doi.org/10.1097/00042737-200302000-00008
Bamba, Tadao ; Shimoyama, Takashi ; Sasaki, Masaya ; Tsujikawa, Tomoyuki ; Fukuda, Yoshihiro ; Koganei, Kazutaka ; Hibi, Toshifumi ; Iwao, Yasushi ; Munakata, Akihiro ; Fukuda, Shinsaku ; Matsumoto, Takayuki ; Oshitani, Nobuhide ; Hiwatashi, Nobuo ; Oriuchi, Tatsuo ; Kitahora, Tetsuji ; Utsunomiya, Toshinori ; Saitoh, Yasushi ; Suzuki, Yasuo ; Nakajima, Mitsuyoshi. / Dietary fat attenuates the benefits of an elemental diet in active Crohn's disease : A randomized, controlled trial. In: European Journal of Gastroenterology and Hepatology. 2003 ; Vol. 15, No. 2. pp. 151-157.
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T1 - Dietary fat attenuates the benefits of an elemental diet in active Crohn's disease

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AU - Bamba, Tadao

AU - Shimoyama, Takashi

AU - Sasaki, Masaya

AU - Tsujikawa, Tomoyuki

AU - Fukuda, Yoshihiro

AU - Koganei, Kazutaka

AU - Hibi, Toshifumi

AU - Iwao, Yasushi

AU - Munakata, Akihiro

AU - Fukuda, Shinsaku

AU - Matsumoto, Takayuki

AU - Oshitani, Nobuhide

AU - Hiwatashi, Nobuo

AU - Oriuchi, Tatsuo

AU - Kitahora, Tetsuji

AU - Utsunomiya, Toshinori

AU - Saitoh, Yasushi

AU - Suzuki, Yasuo

AU - Nakajima, Mitsuyoshi

PY - 2003/2/1

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N2 - Objectives: Although an elemental diet has been established as the primary treatment for patients with Crohn's disease, the influence of dietary fat on the elemental diet remains unclear. We have designed the first randomized, controlled trial for elemental diets containing different fat percentages in patients with active Crohn's disease. Methods: Each patient was randomized to receive one of three dose levels of fat in an elemental diet (Elental) for 4 weeks: 10 patients received low fat (3.06 g/day), 10 patients received medium fat (16.56 g/day) and eight patients received high fat (30.06 g/day). The additional fat was composed of long-chain fatty acids. All patients were evaluated using the International Organization of Inflammatory Bowel Disease rating, plus C-reactive protein level and erythrocyte sedimentation rate, which were measured at weekly intervals. Results: Although the International Organization of Inflammatory Bowel Disease rating, C-reactive protein level and erythrocyte sedimentation rate in the low-fat group decreased, the values in the medium- and high-fat groups fluctuated during the study. The remission rate after 4 weeks in each group was 80%, 40% and 25% for patients in the low-, medium- and high-fat groups, respectively. Conclusions: When the fat consisted of long-chain triglycerides, a high amount of this fat in the elemental diet formula decreased its therapeutic effect against active Crohn's disease.

AB - Objectives: Although an elemental diet has been established as the primary treatment for patients with Crohn's disease, the influence of dietary fat on the elemental diet remains unclear. We have designed the first randomized, controlled trial for elemental diets containing different fat percentages in patients with active Crohn's disease. Methods: Each patient was randomized to receive one of three dose levels of fat in an elemental diet (Elental) for 4 weeks: 10 patients received low fat (3.06 g/day), 10 patients received medium fat (16.56 g/day) and eight patients received high fat (30.06 g/day). The additional fat was composed of long-chain fatty acids. All patients were evaluated using the International Organization of Inflammatory Bowel Disease rating, plus C-reactive protein level and erythrocyte sedimentation rate, which were measured at weekly intervals. Results: Although the International Organization of Inflammatory Bowel Disease rating, C-reactive protein level and erythrocyte sedimentation rate in the low-fat group decreased, the values in the medium- and high-fat groups fluctuated during the study. The remission rate after 4 weeks in each group was 80%, 40% and 25% for patients in the low-, medium- and high-fat groups, respectively. Conclusions: When the fat consisted of long-chain triglycerides, a high amount of this fat in the elemental diet formula decreased its therapeutic effect against active Crohn's disease.

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KW - Dietary fat

KW - Elemental diet

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