TY - JOUR
T1 - Dietary Patterns and Risk of Colorectal Cancer
T2 - Analysis by Tumor Location and Molecular Subtypes
AU - Mehta, Raaj S.
AU - Song, Mingyang
AU - Nishihara, Reiko
AU - Drew, David A.
AU - Wu, Kana
AU - Qian, Zhi Rong
AU - Fung, Teresa T.
AU - Hamada, Tsuyoshi
AU - Masugi, Yohei
AU - da Silva, Annacarolina
AU - Shi, Yan
AU - Li, Wanwan
AU - Gu, Mancang
AU - Willett, Walter C.
AU - Fuchs, Charles S.
AU - Giovannucci, Edward L.
AU - Ogino, Shuji
AU - Chan, Andrew T.
N1 - Publisher Copyright:
© 2017 AGA Institute
PY - 2017/6
Y1 - 2017/6
N2 - Background & Aims Western and prudent dietary patterns have been associated with higher and lower risks of colorectal cancer (CRC), respectively. However, little is known about the associations between dietary patterns and specific anatomic subsites or molecular subtypes of CRC. Methods We used multivariable Cox proportional hazards models to examine the associations between Western and prudent dietary patterns and CRC risk in the Health Professionals Follow-up Study and Nurses’ Health Study. Results After up to 32 years of follow-up of 137,217 men and women, we documented 3260 cases of CRC. Among individuals from whom subsite data were available, we observed 1264 proximal colon, 866 distal colon, and 670 rectal tumors. Western diet was associated with an increased incidence of CRC (Ptrend <.0001), with a relative risk (RR) of 1.31 (95% CI, 1.15–1.48, comparing the highest to lowest quartile). The association of Western diet with CRC was evident for tumors of the distal colon (RR, 1.55; 95% CI, 1.22–1.96; Ptrend =.0004) and rectum (RR, 1.35; 95% CI, 1.03–1.77; Ptrend =.01) but not proximal colon (RR, 1.11; 95% CI, 0.91–1.35; Ptrend =.51) when we comparing extreme quartiles. In contrast, for the prudent pattern, we observed a RR of 0.86 for overall CRC (95% CI, 0.77–0.95; Ptrend =.01), with similar trends at anatomic subsites. However, the trend appeared stronger among men than women. Among 1285 cases (39%) with tissue available for molecular profiling, Western diet appeared to be more strongly associated with some CRC molecular subtypes (no mutations in KRAS [KRAS wildtype] or BRAF [BRAF wildtype], no or a low CpG island methylator phenotype, and microsatellite stability), although formal tests for heterogeneity did not produce statistically significant results. Conclusions Western dietary patterns are associated with an increased risk of CRC, particularly distal colon and rectal tumors. Western dietary patterns also appear more strongly associated with tumors that are KRAS wildtype, BRAF wildtype, have no or a low CpG island methylator phenotype, and microsatellite stability. In contrast, prudent dietary patterns are associated with a lower risk of CRC that does not vary according to anatomic subsite or molecular subtype.
AB - Background & Aims Western and prudent dietary patterns have been associated with higher and lower risks of colorectal cancer (CRC), respectively. However, little is known about the associations between dietary patterns and specific anatomic subsites or molecular subtypes of CRC. Methods We used multivariable Cox proportional hazards models to examine the associations between Western and prudent dietary patterns and CRC risk in the Health Professionals Follow-up Study and Nurses’ Health Study. Results After up to 32 years of follow-up of 137,217 men and women, we documented 3260 cases of CRC. Among individuals from whom subsite data were available, we observed 1264 proximal colon, 866 distal colon, and 670 rectal tumors. Western diet was associated with an increased incidence of CRC (Ptrend <.0001), with a relative risk (RR) of 1.31 (95% CI, 1.15–1.48, comparing the highest to lowest quartile). The association of Western diet with CRC was evident for tumors of the distal colon (RR, 1.55; 95% CI, 1.22–1.96; Ptrend =.0004) and rectum (RR, 1.35; 95% CI, 1.03–1.77; Ptrend =.01) but not proximal colon (RR, 1.11; 95% CI, 0.91–1.35; Ptrend =.51) when we comparing extreme quartiles. In contrast, for the prudent pattern, we observed a RR of 0.86 for overall CRC (95% CI, 0.77–0.95; Ptrend =.01), with similar trends at anatomic subsites. However, the trend appeared stronger among men than women. Among 1285 cases (39%) with tissue available for molecular profiling, Western diet appeared to be more strongly associated with some CRC molecular subtypes (no mutations in KRAS [KRAS wildtype] or BRAF [BRAF wildtype], no or a low CpG island methylator phenotype, and microsatellite stability), although formal tests for heterogeneity did not produce statistically significant results. Conclusions Western dietary patterns are associated with an increased risk of CRC, particularly distal colon and rectal tumors. Western dietary patterns also appear more strongly associated with tumors that are KRAS wildtype, BRAF wildtype, have no or a low CpG island methylator phenotype, and microsatellite stability. In contrast, prudent dietary patterns are associated with a lower risk of CRC that does not vary according to anatomic subsite or molecular subtype.
KW - Colon Cancer Risk
KW - Molecular Epidemiology
KW - Processed Meat
KW - Red Meat
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U2 - 10.1053/j.gastro.2017.02.015
DO - 10.1053/j.gastro.2017.02.015
M3 - Article
C2 - 28249812
AN - SCOPUS:85018630232
SN - 0016-5085
VL - 152
SP - 1944-1953.e1
JO - Gastroenterology
JF - Gastroenterology
IS - 8
ER -
