Difference in the craniocaudal gradient of the maximum pixel value change rate between chronic obstructive pulmonary disease patients and normal subjects using sub-mGy dynamic chest radiography with a flat panel detector system

Yoshitake Yamada, Masako Ueyama, Takehiko Abe, Tetsuro Araki, Takayuki Abe, Mizuki Nishino, Masahiro Jinzaki, Hiroto Hatabu, Shoji Kudoh

Research output: Contribution to journalArticle

Abstract

Objectives To compare the craniocaudal gradients of the maximum pixel value change rate (MPCR) during tidal breathing between chronic obstructive pulmonary disease (COPD) patients and normal subjects using dynamic chest radiography. Materials and methods This prospective study was approved by the institutional review board and all participants provided written informed consent. Forty-three COPD patients (mean age, 71.6 ± 8.7 years) and 47 normal subjects (non-smoker healthy volunteers) (mean age, 54.8 ± 9.8 years) underwent sequential chest radiographs during tidal breathing in a standing position using dynamic chest radiography with a flat panel detector system. We evaluated the craniocaudal gradient of MPCR. The results were analyzed using an unpaired t-test and the Tukey–Kramer method. Results The craniocaudal gradients of MPCR in COPD patients were significantly lower than those in normal subjects (right inspiratory phase, 75.5 ± 48.1 vs. 108.9 ± 42.0 s−1 cm−1, P < 0.001; right expiratory phase, 66.4 ± 40.6 vs. 89.8 ± 31.6 s−1 cm−1, P = 0.003; left inspiratory phase, 75.5 ± 48.2 vs. 108.2 ± 47.2 s−1 cm−1, P = 0.002; left expiratory phase, 60.9 ± 38.2 vs. 84.3 ± 29.5 s−1 cm−1, P = 0.002). No significant differences in height, weight, or BMI were observed between COPD and normal groups. In the sub-analysis, the gradients in severe COPD patients (global initiative for chronic obstructive lung disease [GOLD] 3 or 4, n = 26) were significantly lower than those in mild COPD patients (GOLD 1 or 2, n = 17) for both right and left inspiratory/expiratory phases (all P ≤ 0.005). Conclusions A decrease of the craniocaudal gradient of MPCR was observed in COPD patients. The craniocaudal gradient was lower in severe COPD patients than in mild COPD patients.

Original languageEnglish
Pages (from-to)37-44
Number of pages8
JournalEuropean Journal of Radiology
Volume92
DOIs
Publication statusPublished - 2017 Jul 1

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Radiography
Chronic Obstructive Pulmonary Disease
Thorax
Respiration
Research Ethics Committees
Informed Consent
Posture
Healthy Volunteers
Prospective Studies
Weights and Measures

Keywords

  • Lung
  • Respiration
  • Thorax
  • Ventilation
  • X-ray

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Difference in the craniocaudal gradient of the maximum pixel value change rate between chronic obstructive pulmonary disease patients and normal subjects using sub-mGy dynamic chest radiography with a flat panel detector system. / Yamada, Yoshitake; Ueyama, Masako; Abe, Takehiko; Araki, Tetsuro; Abe, Takayuki; Nishino, Mizuki; Jinzaki, Masahiro; Hatabu, Hiroto; Kudoh, Shoji.

In: European Journal of Radiology, Vol. 92, 01.07.2017, p. 37-44.

Research output: Contribution to journalArticle

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abstract = "Objectives To compare the craniocaudal gradients of the maximum pixel value change rate (MPCR) during tidal breathing between chronic obstructive pulmonary disease (COPD) patients and normal subjects using dynamic chest radiography. Materials and methods This prospective study was approved by the institutional review board and all participants provided written informed consent. Forty-three COPD patients (mean age, 71.6 ± 8.7 years) and 47 normal subjects (non-smoker healthy volunteers) (mean age, 54.8 ± 9.8 years) underwent sequential chest radiographs during tidal breathing in a standing position using dynamic chest radiography with a flat panel detector system. We evaluated the craniocaudal gradient of MPCR. The results were analyzed using an unpaired t-test and the Tukey–Kramer method. Results The craniocaudal gradients of MPCR in COPD patients were significantly lower than those in normal subjects (right inspiratory phase, 75.5 ± 48.1 vs. 108.9 ± 42.0 s−1 cm−1, P < 0.001; right expiratory phase, 66.4 ± 40.6 vs. 89.8 ± 31.6 s−1 cm−1, P = 0.003; left inspiratory phase, 75.5 ± 48.2 vs. 108.2 ± 47.2 s−1 cm−1, P = 0.002; left expiratory phase, 60.9 ± 38.2 vs. 84.3 ± 29.5 s−1 cm−1, P = 0.002). No significant differences in height, weight, or BMI were observed between COPD and normal groups. In the sub-analysis, the gradients in severe COPD patients (global initiative for chronic obstructive lung disease [GOLD] 3 or 4, n = 26) were significantly lower than those in mild COPD patients (GOLD 1 or 2, n = 17) for both right and left inspiratory/expiratory phases (all P ≤ 0.005). Conclusions A decrease of the craniocaudal gradient of MPCR was observed in COPD patients. The craniocaudal gradient was lower in severe COPD patients than in mild COPD patients.",
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author = "Yoshitake Yamada and Masako Ueyama and Takehiko Abe and Tetsuro Araki and Takayuki Abe and Mizuki Nishino and Masahiro Jinzaki and Hiroto Hatabu and Shoji Kudoh",
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T1 - Difference in the craniocaudal gradient of the maximum pixel value change rate between chronic obstructive pulmonary disease patients and normal subjects using sub-mGy dynamic chest radiography with a flat panel detector system

AU - Yamada, Yoshitake

AU - Ueyama, Masako

AU - Abe, Takehiko

AU - Araki, Tetsuro

AU - Abe, Takayuki

AU - Nishino, Mizuki

AU - Jinzaki, Masahiro

AU - Hatabu, Hiroto

AU - Kudoh, Shoji

PY - 2017/7/1

Y1 - 2017/7/1

N2 - Objectives To compare the craniocaudal gradients of the maximum pixel value change rate (MPCR) during tidal breathing between chronic obstructive pulmonary disease (COPD) patients and normal subjects using dynamic chest radiography. Materials and methods This prospective study was approved by the institutional review board and all participants provided written informed consent. Forty-three COPD patients (mean age, 71.6 ± 8.7 years) and 47 normal subjects (non-smoker healthy volunteers) (mean age, 54.8 ± 9.8 years) underwent sequential chest radiographs during tidal breathing in a standing position using dynamic chest radiography with a flat panel detector system. We evaluated the craniocaudal gradient of MPCR. The results were analyzed using an unpaired t-test and the Tukey–Kramer method. Results The craniocaudal gradients of MPCR in COPD patients were significantly lower than those in normal subjects (right inspiratory phase, 75.5 ± 48.1 vs. 108.9 ± 42.0 s−1 cm−1, P < 0.001; right expiratory phase, 66.4 ± 40.6 vs. 89.8 ± 31.6 s−1 cm−1, P = 0.003; left inspiratory phase, 75.5 ± 48.2 vs. 108.2 ± 47.2 s−1 cm−1, P = 0.002; left expiratory phase, 60.9 ± 38.2 vs. 84.3 ± 29.5 s−1 cm−1, P = 0.002). No significant differences in height, weight, or BMI were observed between COPD and normal groups. In the sub-analysis, the gradients in severe COPD patients (global initiative for chronic obstructive lung disease [GOLD] 3 or 4, n = 26) were significantly lower than those in mild COPD patients (GOLD 1 or 2, n = 17) for both right and left inspiratory/expiratory phases (all P ≤ 0.005). Conclusions A decrease of the craniocaudal gradient of MPCR was observed in COPD patients. The craniocaudal gradient was lower in severe COPD patients than in mild COPD patients.

AB - Objectives To compare the craniocaudal gradients of the maximum pixel value change rate (MPCR) during tidal breathing between chronic obstructive pulmonary disease (COPD) patients and normal subjects using dynamic chest radiography. Materials and methods This prospective study was approved by the institutional review board and all participants provided written informed consent. Forty-three COPD patients (mean age, 71.6 ± 8.7 years) and 47 normal subjects (non-smoker healthy volunteers) (mean age, 54.8 ± 9.8 years) underwent sequential chest radiographs during tidal breathing in a standing position using dynamic chest radiography with a flat panel detector system. We evaluated the craniocaudal gradient of MPCR. The results were analyzed using an unpaired t-test and the Tukey–Kramer method. Results The craniocaudal gradients of MPCR in COPD patients were significantly lower than those in normal subjects (right inspiratory phase, 75.5 ± 48.1 vs. 108.9 ± 42.0 s−1 cm−1, P < 0.001; right expiratory phase, 66.4 ± 40.6 vs. 89.8 ± 31.6 s−1 cm−1, P = 0.003; left inspiratory phase, 75.5 ± 48.2 vs. 108.2 ± 47.2 s−1 cm−1, P = 0.002; left expiratory phase, 60.9 ± 38.2 vs. 84.3 ± 29.5 s−1 cm−1, P = 0.002). No significant differences in height, weight, or BMI were observed between COPD and normal groups. In the sub-analysis, the gradients in severe COPD patients (global initiative for chronic obstructive lung disease [GOLD] 3 or 4, n = 26) were significantly lower than those in mild COPD patients (GOLD 1 or 2, n = 17) for both right and left inspiratory/expiratory phases (all P ≤ 0.005). Conclusions A decrease of the craniocaudal gradient of MPCR was observed in COPD patients. The craniocaudal gradient was lower in severe COPD patients than in mild COPD patients.

KW - Lung

KW - Respiration

KW - Thorax

KW - Ventilation

KW - X-ray

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