Differences between gastric signet-ring cell carcinoma and poorly differentiated adenocarcinoma: A comparison of histopathologic features determined by mucin core protein and trefoil factor family peptide immunohistochemistry

Ai Fujimoto, Yukio Ishikawa, Toshiharu Ishii, Akihiro Yamada, Yoshinori Igarashi, Yasukazu Ohmoto, Mitsuru Kaise

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We investigated differences between the pathological features of gastric signet-ring cell carcinoma (sig) and poorly differentiated adenocarcinoma (por) by examining the expressions of the trefoil factor family peptides (TFFs) and mucin core proteins (MUCs). Ninety-seven tissues of 97 gastric cancer patients were selected for this study. After gastrectomy, the major histopathologic types were determined to be sig, solid-type poorly differentiated adenocarcinoma (por1), non-solid type poorly differentiated adenocarcinoma (por2), and well-differentiated tubular adenocarcinoma (tub1). We evaluated the prevalence of positive staining for MUCs (MUC5AC and MUC2) and TFFs (TFF1 and TFF3) and assessed the correlation between MUCs and TFFs in each histopathological type. The rate of MUC2 expression significantly differed between sig and por2 (50.0% vs 11.7%, P = 0.011). TFF3 expression in sig significantly differed from TFF3 expression in both por2 (100% vs 17.6%, P < 0.0001) and por1 (100% vs 33.3%, P = 0.0004). MUC5AC and TFF1 expressions were significantly correlated in por1 (r = 0.705, P = 0.002), por2 (r = 0.535, P = 0.0009), and tub1 (r = 0.470, P = 0.0034), while MUC2 and TFF3 expressions were significantly correlated only in sig (r = 0.593, P = 0.040). The expression and correlation patterns of the TFFs and MUCs suggest that the histopathologic features of gastric sig differ from those of por.

Original languageEnglish
Pages (from-to)398-403
Number of pages6
JournalPathology International
Volume67
Issue number8
DOIs
Publication statusPublished - 2017 Aug 1

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Signet Ring Cell Carcinoma
Mucins
Stomach
Adenocarcinoma
Immunohistochemistry
Proteins
Gastrectomy
Stomach Neoplasms
Staining and Labeling
Trefoil Factors

Keywords

  • gastric cancer
  • immunohistochemistry
  • mucin core proteins
  • poorly differentiated adenocarcinoma
  • signet-ring cell carcinoma
  • trefoil factor family peptides

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Differences between gastric signet-ring cell carcinoma and poorly differentiated adenocarcinoma : A comparison of histopathologic features determined by mucin core protein and trefoil factor family peptide immunohistochemistry. / Fujimoto, Ai; Ishikawa, Yukio; Ishii, Toshiharu; Yamada, Akihiro; Igarashi, Yoshinori; Ohmoto, Yasukazu; Kaise, Mitsuru.

In: Pathology International, Vol. 67, No. 8, 01.08.2017, p. 398-403.

Research output: Contribution to journalArticle

Fujimoto, Ai ; Ishikawa, Yukio ; Ishii, Toshiharu ; Yamada, Akihiro ; Igarashi, Yoshinori ; Ohmoto, Yasukazu ; Kaise, Mitsuru. / Differences between gastric signet-ring cell carcinoma and poorly differentiated adenocarcinoma : A comparison of histopathologic features determined by mucin core protein and trefoil factor family peptide immunohistochemistry. In: Pathology International. 2017 ; Vol. 67, No. 8. pp. 398-403.
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AU - Ishii, Toshiharu

AU - Yamada, Akihiro

AU - Igarashi, Yoshinori

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AU - Kaise, Mitsuru

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AB - We investigated differences between the pathological features of gastric signet-ring cell carcinoma (sig) and poorly differentiated adenocarcinoma (por) by examining the expressions of the trefoil factor family peptides (TFFs) and mucin core proteins (MUCs). Ninety-seven tissues of 97 gastric cancer patients were selected for this study. After gastrectomy, the major histopathologic types were determined to be sig, solid-type poorly differentiated adenocarcinoma (por1), non-solid type poorly differentiated adenocarcinoma (por2), and well-differentiated tubular adenocarcinoma (tub1). We evaluated the prevalence of positive staining for MUCs (MUC5AC and MUC2) and TFFs (TFF1 and TFF3) and assessed the correlation between MUCs and TFFs in each histopathological type. The rate of MUC2 expression significantly differed between sig and por2 (50.0% vs 11.7%, P = 0.011). TFF3 expression in sig significantly differed from TFF3 expression in both por2 (100% vs 17.6%, P < 0.0001) and por1 (100% vs 33.3%, P = 0.0004). MUC5AC and TFF1 expressions were significantly correlated in por1 (r = 0.705, P = 0.002), por2 (r = 0.535, P = 0.0009), and tub1 (r = 0.470, P = 0.0034), while MUC2 and TFF3 expressions were significantly correlated only in sig (r = 0.593, P = 0.040). The expression and correlation patterns of the TFFs and MUCs suggest that the histopathologic features of gastric sig differ from those of por.

KW - gastric cancer

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KW - poorly differentiated adenocarcinoma

KW - signet-ring cell carcinoma

KW - trefoil factor family peptides

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