Abstract
We investigated differences between the pathological features of gastric signet-ring cell carcinoma (sig) and poorly differentiated adenocarcinoma (por) by examining the expressions of the trefoil factor family peptides (TFFs) and mucin core proteins (MUCs). Ninety-seven tissues of 97 gastric cancer patients were selected for this study. After gastrectomy, the major histopathologic types were determined to be sig, solid-type poorly differentiated adenocarcinoma (por1), non-solid type poorly differentiated adenocarcinoma (por2), and well-differentiated tubular adenocarcinoma (tub1). We evaluated the prevalence of positive staining for MUCs (MUC5AC and MUC2) and TFFs (TFF1 and TFF3) and assessed the correlation between MUCs and TFFs in each histopathological type. The rate of MUC2 expression significantly differed between sig and por2 (50.0% vs 11.7%, P = 0.011). TFF3 expression in sig significantly differed from TFF3 expression in both por2 (100% vs 17.6%, P < 0.0001) and por1 (100% vs 33.3%, P = 0.0004). MUC5AC and TFF1 expressions were significantly correlated in por1 (r = 0.705, P = 0.002), por2 (r = 0.535, P = 0.0009), and tub1 (r = 0.470, P = 0.0034), while MUC2 and TFF3 expressions were significantly correlated only in sig (r = 0.593, P = 0.040). The expression and correlation patterns of the TFFs and MUCs suggest that the histopathologic features of gastric sig differ from those of por.
| Original language | English |
|---|---|
| Pages (from-to) | 398-403 |
| Number of pages | 6 |
| Journal | Pathology International |
| Volume | 67 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 2017 Aug 1 |
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Keywords
- gastric cancer
- immunohistochemistry
- mucin core proteins
- poorly differentiated adenocarcinoma
- signet-ring cell carcinoma
- trefoil factor family peptides
ASJC Scopus subject areas
- Pathology and Forensic Medicine
Cite this
Differences between gastric signet-ring cell carcinoma and poorly differentiated adenocarcinoma : A comparison of histopathologic features determined by mucin core protein and trefoil factor family peptide immunohistochemistry. / Fujimoto, Ai; Ishikawa, Yukio; Ishii, Toshiharu; Yamada, Akihiro; Igarashi, Yoshinori; Ohmoto, Yasukazu; Kaise, Mitsuru.
In: Pathology International, Vol. 67, No. 8, 01.08.2017, p. 398-403.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Differences between gastric signet-ring cell carcinoma and poorly differentiated adenocarcinoma
T2 - A comparison of histopathologic features determined by mucin core protein and trefoil factor family peptide immunohistochemistry
AU - Fujimoto, Ai
AU - Ishikawa, Yukio
AU - Ishii, Toshiharu
AU - Yamada, Akihiro
AU - Igarashi, Yoshinori
AU - Ohmoto, Yasukazu
AU - Kaise, Mitsuru
PY - 2017/8/1
Y1 - 2017/8/1
N2 - We investigated differences between the pathological features of gastric signet-ring cell carcinoma (sig) and poorly differentiated adenocarcinoma (por) by examining the expressions of the trefoil factor family peptides (TFFs) and mucin core proteins (MUCs). Ninety-seven tissues of 97 gastric cancer patients were selected for this study. After gastrectomy, the major histopathologic types were determined to be sig, solid-type poorly differentiated adenocarcinoma (por1), non-solid type poorly differentiated adenocarcinoma (por2), and well-differentiated tubular adenocarcinoma (tub1). We evaluated the prevalence of positive staining for MUCs (MUC5AC and MUC2) and TFFs (TFF1 and TFF3) and assessed the correlation between MUCs and TFFs in each histopathological type. The rate of MUC2 expression significantly differed between sig and por2 (50.0% vs 11.7%, P = 0.011). TFF3 expression in sig significantly differed from TFF3 expression in both por2 (100% vs 17.6%, P < 0.0001) and por1 (100% vs 33.3%, P = 0.0004). MUC5AC and TFF1 expressions were significantly correlated in por1 (r = 0.705, P = 0.002), por2 (r = 0.535, P = 0.0009), and tub1 (r = 0.470, P = 0.0034), while MUC2 and TFF3 expressions were significantly correlated only in sig (r = 0.593, P = 0.040). The expression and correlation patterns of the TFFs and MUCs suggest that the histopathologic features of gastric sig differ from those of por.
AB - We investigated differences between the pathological features of gastric signet-ring cell carcinoma (sig) and poorly differentiated adenocarcinoma (por) by examining the expressions of the trefoil factor family peptides (TFFs) and mucin core proteins (MUCs). Ninety-seven tissues of 97 gastric cancer patients were selected for this study. After gastrectomy, the major histopathologic types were determined to be sig, solid-type poorly differentiated adenocarcinoma (por1), non-solid type poorly differentiated adenocarcinoma (por2), and well-differentiated tubular adenocarcinoma (tub1). We evaluated the prevalence of positive staining for MUCs (MUC5AC and MUC2) and TFFs (TFF1 and TFF3) and assessed the correlation between MUCs and TFFs in each histopathological type. The rate of MUC2 expression significantly differed between sig and por2 (50.0% vs 11.7%, P = 0.011). TFF3 expression in sig significantly differed from TFF3 expression in both por2 (100% vs 17.6%, P < 0.0001) and por1 (100% vs 33.3%, P = 0.0004). MUC5AC and TFF1 expressions were significantly correlated in por1 (r = 0.705, P = 0.002), por2 (r = 0.535, P = 0.0009), and tub1 (r = 0.470, P = 0.0034), while MUC2 and TFF3 expressions were significantly correlated only in sig (r = 0.593, P = 0.040). The expression and correlation patterns of the TFFs and MUCs suggest that the histopathologic features of gastric sig differ from those of por.
KW - gastric cancer
KW - immunohistochemistry
KW - mucin core proteins
KW - poorly differentiated adenocarcinoma
KW - signet-ring cell carcinoma
KW - trefoil factor family peptides
UR - http://www.scopus.com/inward/record.url?scp=85022334371&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85022334371&partnerID=8YFLogxK
U2 - 10.1111/pin.12559
DO - 10.1111/pin.12559
M3 - Article
AN - SCOPUS:85022334371
VL - 67
SP - 398
EP - 403
JO - Pathology International
JF - Pathology International
SN - 1320-5463
IS - 8
ER -