Differences between infrared spectra of normal and neoplastic human gastric cells

Naoko Fujioka, Yuji Morimoto, Tsunenori Arai, Kyoko Takeuchi, Masahiko Yoshioka, Makoto Kikuchi

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We investigated the differences in Fourier transform-infrared (FT-IR) spectra between normal and neoplastic human gastric cells. The infrared spectra derived from the cancer cells (AGS, SNU-1, and NCI-N87) showed a significant increase in infrared absorption in the band around 1240 cm-1, 1120 cm-1 and 1080 cm-1, compared with those from the normal gastric epithelial cells we established in culture. In addition, frequency shifts of 4.6 cm-1 and 3.8 cm-1 were seen at the peak absorbance in the bands around 1240 cm-1 and 1080 cm-1, respectively. These spectral differences reflected the differences between the phosphate backbone in the normal and neoplastic human gastric cells. The present results suggest that FT-IR spectroscopy is a potential new tool for gastric cancer diagnosis.

Original languageEnglish
Pages (from-to)59-66
Number of pages8
JournalSpectroscopy
Volume18
Issue number1
Publication statusPublished - 2004

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Infrared radiation
Infrared absorption
Fourier transforms
Phosphates
Cells
Epithelial Cells

ASJC Scopus subject areas

  • Spectroscopy

Cite this

Fujioka, N., Morimoto, Y., Arai, T., Takeuchi, K., Yoshioka, M., & Kikuchi, M. (2004). Differences between infrared spectra of normal and neoplastic human gastric cells. Spectroscopy, 18(1), 59-66.

Differences between infrared spectra of normal and neoplastic human gastric cells. / Fujioka, Naoko; Morimoto, Yuji; Arai, Tsunenori; Takeuchi, Kyoko; Yoshioka, Masahiko; Kikuchi, Makoto.

In: Spectroscopy, Vol. 18, No. 1, 2004, p. 59-66.

Research output: Contribution to journalArticle

Fujioka, N, Morimoto, Y, Arai, T, Takeuchi, K, Yoshioka, M & Kikuchi, M 2004, 'Differences between infrared spectra of normal and neoplastic human gastric cells', Spectroscopy, vol. 18, no. 1, pp. 59-66.
Fujioka N, Morimoto Y, Arai T, Takeuchi K, Yoshioka M, Kikuchi M. Differences between infrared spectra of normal and neoplastic human gastric cells. Spectroscopy. 2004;18(1):59-66.
Fujioka, Naoko ; Morimoto, Yuji ; Arai, Tsunenori ; Takeuchi, Kyoko ; Yoshioka, Masahiko ; Kikuchi, Makoto. / Differences between infrared spectra of normal and neoplastic human gastric cells. In: Spectroscopy. 2004 ; Vol. 18, No. 1. pp. 59-66.
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