Differences in clinicopathological and biological features between central-type and peripheral-type squamous cell carcinoma of the lung

Takamoto Saijo, Genichiro Ishii, Kanji Nagai, Kazuhito Funai, Junichi Nitadori, Koji Tsuta, Michiya Nara, Tomoyuki Hishida, Atsushi Ochiai

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The central type and peripheral type squamous cell carcinoma (SCC) of the lung have different clinicopathological characteristics, but, little is known about their biological characteristics. We investigated differences between the properties and phenotypes of peripheral-type (P-type) and central-type (C-type) SCC by performing an immunohistochemical analysis of each type by tissue microarray analysis with a large panel of antibodies. To examine strictly, we selected 20 P-type SCCs that were pathological stage T1 and limited to more peripherally than the fifth bronchial bifurcation, and 21 C-type SCCs that were pathological stage T1 and limited to a lobar bronchus. The results of the clinicopathological study showed that the patients with P-type SCC were significantly older than the patients with C-type SCC and that squamous metaplasia was predominant in C-type SCC than in P-type SCC. The 36 antibodies revealed different expression patterns of cytokeratin 7 (CK 7) and cytokeratin 19 (CK 19) between C-type and P-type SCC. CK 7 expression was more predominant in P-type SCC than in C-type SCC, and CK 19 expression was more predominant in C-type SCC than in P-type SCC. These results suggest that C-type and P-type SCC have different clinicopathological and biological features.

Original languageEnglish
Pages (from-to)37-45
Number of pages9
JournalLung Cancer
Volume52
Issue number1
DOIs
Publication statusPublished - 2006 Apr 1
Externally publishedYes

Keywords

  • CK 19
  • CK 7
  • Central
  • Peripheral
  • Squamous cell carcinoma
  • Tissue microarray

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research

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