Differences of migratory behavior between direct progeny of apical progenitors and basal progenitors in the developing cerebral cortex

Hidenori Tabata, Shigeaki Kanatani, Kazunori Nakajima

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

Cerebral cortical neurons are known to be produced from both apical progenitors in the ventricular zone (VZ) and basal (intermediate) progenitors in the subventricular zone (SVZ). On the other hand, we have shown that many SVZ cells assume multipolar morphology and show a characteristic movement termed "multipolar migration." The relationship between multipolar cells and basal progenitors in the SVZ has yet to be investigated. Herein, we followed postmitotic cells generated in the VZ and found that they stayed for more than 10 h in the VZ after becoming postmitotic and then accumulated in the lower part of the SVZ (multipolar cell accumulation zone: MAZ) as multipolar cells (slowly exiting population: SEP), whereas basal progenitors rapidly migrated into the SVZ or intermediate zone (IZ) (rapidly exiting population: REP) with somal translocation morphology. Although REP reached the SVZ/IZ earlier than the SEP, REP stayed within in the SVZ/IZ, whereas SEP moved steadily and entered the CP prior to the REP. We also observed SEP to eventually differentiate into pyramidal neurons in layers II/III. This study provides in vivo evidence of differences in migration modes between postmitotic cells generated from apical progenitors and basal progenitors.

Original languageEnglish
Pages (from-to)2092-2105
Number of pages14
JournalCerebral Cortex
Volume19
Issue number9
DOIs
Publication statusPublished - 2009 Sep 1

Keywords

  • Cerebral cortex
  • Mouse
  • Multipolar cell accumulation zone (MAZ)
  • Multipolar migration
  • Subventricular zone

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

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