Different chemo- and endocrino- sensitivity of MCF-7 cells with or without estradiol supplement in vitro

H. Tanino, T. Kubota, Y. Saikawa, T. H. Kuo, T. Takeuchi, S. Kase, T. Furukawa, M. Kitajima, T. Sakurai, Y. Naito, R. M. Hoffman

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Abstract

The sensitivity of MCF-7 cells to tamoxifen (TAM) and mitomycin C (MMC) was assessed in rapidly and slowly growing cells with or without estradiol supplementation, respectively. The growth of MCF-7 was inhibited by MMC in a concentration-dependent manner with or without estradiol (E2) supplementation. Preincubation with MMC suppressed subsequent E2 stimulated growth of MCF-7. TAM inhibited the growth of MCF-7 supplemented with E2, and preincubation with TAM prevented subsequent E2 stimulated growth of MCF-7. However, TAM did not inhibit the growth of MCF-7 cells in E2 free medium. These results suggested that MMC may be more effective than TAM on breast cancer cells in the dormant or slow-growth phase.

Original languageEnglish
Pages (from-to)1219-1221
Number of pages3
JournalAnticancer research
Volume13
Issue number4
Publication statusPublished - 1993 Jan 1

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Keywords

  • Breast cancer
  • Chemo-endocrine therapy
  • In vitro culture
  • Mitomycin C
  • Tamoxifen

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Tanino, H., Kubota, T., Saikawa, Y., Kuo, T. H., Takeuchi, T., Kase, S., Furukawa, T., Kitajima, M., Sakurai, T., Naito, Y., & Hoffman, R. M. (1993). Different chemo- and endocrino- sensitivity of MCF-7 cells with or without estradiol supplement in vitro. Anticancer research, 13(4), 1219-1221.