Different effects of cytochalasins on the growth and differentiation of Entamoeba invadens

Asao Makioka, Masahiro Kumagai, Seiki Kobayashi, Tsutomu Takeuchi

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7 Citations (Scopus)

Abstract

The effect of five different cytochalasins on the growth, encystation and excystation of Entamoeba invadens was examined. At 10 μM, cytochalasins B, D, E and dihydrocytochalasin B markedly inhibited growth. Encystation was inhibited by cytochalasin D at 1 μM but not by other cytochalasins at the same concentration, whereas it was inhibited by 10 μM of cytochalasins B, E and dihydrocytochalasin B as well as cytochalasin D. Excystation, which was assessed by counting the number of metacystic amoebae after inducing excystation, was markedly enhanced by cytochalasin D as previously demonstrated, whereas the enhancing effect of cytochalasins A, B and dihydrocytochalasin B was weak. In contrast, cytochalasin E at 10 μM inhibited excystation and metacystic development. These results indicate that there is a difference in the effect of different cytochalasins on the growth and differentiation of E. invadens, depending on differences in their chemical structure.

Original languageEnglish
Pages (from-to)68-71
Number of pages4
JournalParasitology Research
Volume93
Issue number1
DOIs
Publication statusPublished - 2004 May

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Cytochalasins
cytochalasins
Entamoeba
Cytochalasin D
Cytochalasin B
excystation
cytochalasin D
encystment
Growth
cytochalasin B
Amoeba
chemical structure
dihydrocytochalasin B
Entamoeba invadens
cytochalasin E

ASJC Scopus subject areas

  • Parasitology

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Different effects of cytochalasins on the growth and differentiation of Entamoeba invadens. / Makioka, Asao; Kumagai, Masahiro; Kobayashi, Seiki; Takeuchi, Tsutomu.

In: Parasitology Research, Vol. 93, No. 1, 05.2004, p. 68-71.

Research output: Contribution to journalArticle

Makioka, Asao ; Kumagai, Masahiro ; Kobayashi, Seiki ; Takeuchi, Tsutomu. / Different effects of cytochalasins on the growth and differentiation of Entamoeba invadens. In: Parasitology Research. 2004 ; Vol. 93, No. 1. pp. 68-71.
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