Different expression of surfactant protein B mature peptide and proprotein at 21 weeks' gestation in human fetal pulmonary epithelial cells

Kazuhiro Mori, Kazushige Ikeda, Mamoru Tanaka

Research output: Contribution to journalArticle

1 Citation (Scopus)


Aim: The aim of this study is to evaluate the maturation of pulmonary epithelial cells in human fetal lungs at 21 weeks' gestation. Methods: Eight fetuses at 21 weeks' gestation were evaluated. The maturation of pulmonary epithelial cells was assessed by immunohistochemical examination for surfactant proteins and by electron microscopy. Results: Surfactant protein B mature peptide was detected slightly in the epithelial lining of the bronchioles, but was totally absent in the terminal airways. Surfactant protein B proprotein was clearly detected in the epithelial lining of both bronchioles and terminal airways. Transmission electron microscopy of terminal airway cells showed abundant glycogen granules and few intracellular organelles. Conclusions: The production of mature surfactant protein B in terminal airways is scarce at 21 weeks' gestation, which is associated with the immature mechanism of proprotein processing in the cytoplasm.

Original languageEnglish
Pages (from-to)500-504
Number of pages5
JournalPediatrics International
Issue number5
Publication statusPublished - 2002 Oct 1



  • Human fetus
  • Lung maturation
  • Pulmonary epithelial cells
  • Surfactant protein

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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