Different intra-cerebrospinal distribution of linezolid in patients with inflammatory meningitis

Naoki Ichinose, Gakushi Yoshikawa, Eri Fukao, Mai Ichisawa, Tomoaki Takahata, Yuki Enoki, Kazuaki Taguchi, Toshimi Oda, Kazuo Tsutsumi, Kazuaki Matsumoto

Research output: Contribution to journalArticlepeer-review

Abstract

Linezolid has excellent antibiotic activity against gram-positive organisms and is expected to be an alternative to vancomycin for the treatment of bacterial meningitis. Accumulated evidence has shown the superior pharmacokinetic characteristics of linezolid to vancomycin, such as cerebrospinal fluid penetration. However, in the treatment of meningitis, pharmacokinetic information regarding the intra-cerebrospinal distribution of linezolid and the effects of drainage on the linezolid concentration in the cerebrospinal fluid are unclear. This report describes two patient cases, in which the linezolid concentrations in the cerebrospinal fluid were in the following order: subarachnoid space (cisternal drainage and lumbar puncture) ≥ third ventricle > lateral ventricle. In addition, the linezolid concentration in the cerebrospinal fluid, collected via lumbar puncture, tended to increase after removal of the drainage. This report is novel in presenting two cases of meningitis that showed different intra-cerebrospinal distribution of linezolid in various parts of the central nervous system and an increased linezolid concentration in the cerebrospinal fluid after removal of the drainage.

Original languageEnglish
Pages (from-to)382-384
Number of pages3
JournalInternational Journal of Infectious Diseases
Volume110
DOIs
Publication statusPublished - 2021 Sep

Keywords

  • Cerebrospinal fluid
  • Drainage
  • Linezolid
  • Meningitis
  • Pharmacokinetic

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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