Differential blocking effects of a spider toxin on synaptic and glutamate responses in the afferent synapse of the acoustico-lateralis receptors of Plotosus

Takatoshi Nagai, Shosaku Obara, Nobufumi Kawai

Research output: Contribution to journal › Article

22 Citations (Scopus)

Abstract

The hypothesis that glutamate is the afferent transmitter in the acoustico-lateralis receptors was examined in Plotosus electroreceptors. JSTX, a spider toxin known to specifically block glutamate receptors, irreversibly abolished afferent impulse discharges induced by iontophoretically applied glutamate, whereas those induced synaptically by focal stimulation of receptor cells were little affected. Such differential blocking effects by JSTX, complementary to other biochemical data, further provide pharmacological evidence against the glutamate hypothesis.

Original languageEnglish
Pages (from-to)183-187
Number of pages5
JournalBrain Research
Volume300
Issue number1
DOIs
Publication statusPublished - 1984 May 21
Externally publishedYes

Fingerprint

Catfishes
Spiders
Synapses
Glutamic Acid
Glutamate Receptors
Pharmacology
JSTX spider toxin

Keywords

  • acoustico-lateralis receptor
  • afferent synapse
  • glutamate receptor
  • iontophoresis
  • neurotransmitter
  • spider toxin

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Differential blocking effects of a spider toxin on synaptic and glutamate responses in the afferent synapse of the acoustico-lateralis receptors of Plotosus. / Nagai, Takatoshi; Obara, Shosaku; Kawai, Nobufumi.

In: Brain Research, Vol. 300, No. 1, 21.05.1984, p. 183-187.

Research output: Contribution to journal › Article

Nagai, T, Obara, S & Kawai, N 1984, 'Differential blocking effects of a spider toxin on synaptic and glutamate responses in the afferent synapse of the acoustico-lateralis receptors of Plotosus', Brain Research, vol. 300, no. 1, pp. 183-187. https://doi.org/10.1016/0006-8993(84)91357-X
Nagai T, Obara S, Kawai N. Differential blocking effects of a spider toxin on synaptic and glutamate responses in the afferent synapse of the acoustico-lateralis receptors of Plotosus. Brain Research. 1984 May 21;300(1):183-187. https://doi.org/10.1016/0006-8993(84)91357-X
Nagai, Takatoshi ; Obara, Shosaku ; Kawai, Nobufumi. / Differential blocking effects of a spider toxin on synaptic and glutamate responses in the afferent synapse of the acoustico-lateralis receptors of Plotosus. In: Brain Research. 1984 ; Vol. 300, No. 1. pp. 183-187.
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