Differential changes in quality of life components over 5 years in chronic obstructive pulmonary disease patients

Katsura Nagai, Hironi Makita, Masaru Suzuki, Kaoruko Shimizu, Satoshi Konno, Yoichi M. Ito, Masaharu Nishimura, behalf of the Hokkaido COPD Cohort Study Investigators On behalf of the Hokkaido COPD Cohort Study Investigators, Yoshikazu Kawakami, Youichi Nishiura, Hiroshi Saito, Tetsuya Kojima, Takeshi Igarashi, Kiyonobu Kimura, Ikuo Nakano, Moto Katabami, Kouichi Itabashi, Kiyoshi Morikawa, Seiichi Tagami, Yoshihiro OtsukaRika Sato, Junichiro Kojima, Shinji Nigawara, Takashi Morioka, Ichiro Sakai, Hiroshi Yamamoto, Shigeaki Ogura, Kenji Akie, Fumihiro Honmura, Shinichi Kusudou, Hiroshi Izumi, Kensuke Baba, Hiroki Goya, Tsuyoshi Nakano, Kimihiro Takeyabu, Yasushi Akiyama, Fujiya Kishi, Akihide Ito, Michihiro Fujino, Masashi Ohe, Toshiyuki Harada, Akira Kamimura, Nobuyuki Hakuma, Noriaki Sukou, Kazuo Takaoka, Isamu Doi, Atsushi Ishimine, Ryouji Nakano, Yasushi Hasegawa, Yasuyuki Nasuhara, Tomoko Betsuyaku, Kunio Hamada, Yoko Ito, Motoko Kobayashi, Takeshi Hosokawa, Satoshi Fuke, Masaru Hasegawa, Nao Odajima, Chinatsu Moriyama, Takayuki Yoshida, Takashi Inomata, Kanako Maki, Eiji Shibuya, Tsukasa Sasaki, Katsuaki Nitta, Masafumi Yamamoto, Shigetaka Mizuno, Kenji Miyamoto, Nobuyuki Hizawa

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: The aim of the study was to examine the longitudinal change in quality of life components of patients with chronic obstructive pulmonary disease (COPD). Methods: In the Hokkaido COPD Cohort Study, 261 subjects were appropriately treated and followed over 5 years with a 74% follow-up rate at the end. The longitudinal changes in St George’s Respiratory Questionnaire (SGRQ) scores were annually evaluated with forced expiratory volume in 1 second (FEV<inf>1</inf>). The subjects were classified into the rapid decliners, slow decliners, and sustainers based on ΔFEV<inf>1</inf>/year. Results: The activity component of SGRQ generally deteriorated over time, and its annual decline was the greatest in the rapid decliners (<25th percentile). In contrast, the symptom component improved significantly year by year in the sustainers (>75 percentile), and it did not deteriorate even in the rapid decliners. Of the baseline data, predictors for worsening of the activity component were older age and lower body mass index. Larger reversibility was related to symptom component improvement. Of the follow-up data, ΔFEV<inf>1</inf>/year was the best predictor for worsening of the components of SGRQ. Continuous smoking was another factor for worsening of the activity component. For the symptom component, a history of exacerbation by admission definition was the determinant of its deterioration, whereas use of beta agonists was related to improvement. Conclusion: The longitudinal changes of quality of life and their determinants are markedly different and independent between its components. The activity component of SGRQ generally deteriorated over years, while the symptom component rather improved in some patients with COPD under appropriate treatment.

Original languageEnglish
Pages (from-to)745-757
Number of pages13
JournalInternational Journal of COPD
Volume10
DOIs
Publication statusPublished - 2015 Apr 13
Externally publishedYes

Fingerprint

Chronic Obstructive Pulmonary Disease
Forced Expiratory Volume
Quality of Life
Body Mass Index
Cohort Studies
Smoking
Surveys and Questionnaires
Therapeutics

Keywords

  • Annual change
  • Exacerbation
  • Forced expiratory volume in 1 second
  • SGRQ
  • Smoking

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Public Health, Environmental and Occupational Health
  • Health Policy

Cite this

Differential changes in quality of life components over 5 years in chronic obstructive pulmonary disease patients. / Nagai, Katsura; Makita, Hironi; Suzuki, Masaru; Shimizu, Kaoruko; Konno, Satoshi; Ito, Yoichi M.; Nishimura, Masaharu; On behalf of the Hokkaido COPD Cohort Study Investigators, behalf of the Hokkaido COPD Cohort Study Investigators; Kawakami, Yoshikazu; Nishiura, Youichi; Saito, Hiroshi; Kojima, Tetsuya; Igarashi, Takeshi; Kimura, Kiyonobu; Nakano, Ikuo; Katabami, Moto; Itabashi, Kouichi; Morikawa, Kiyoshi; Tagami, Seiichi; Otsuka, Yoshihiro; Sato, Rika; Kojima, Junichiro; Nigawara, Shinji; Morioka, Takashi; Sakai, Ichiro; Yamamoto, Hiroshi; Ogura, Shigeaki; Akie, Kenji; Honmura, Fumihiro; Kusudou, Shinichi; Izumi, Hiroshi; Baba, Kensuke; Goya, Hiroki; Nakano, Tsuyoshi; Takeyabu, Kimihiro; Akiyama, Yasushi; Kishi, Fujiya; Ito, Akihide; Fujino, Michihiro; Ohe, Masashi; Harada, Toshiyuki; Kamimura, Akira; Hakuma, Nobuyuki; Sukou, Noriaki; Takaoka, Kazuo; Doi, Isamu; Ishimine, Atsushi; Nakano, Ryouji; Hasegawa, Yasushi; Nasuhara, Yasuyuki; Betsuyaku, Tomoko; Hamada, Kunio; Ito, Yoko; Kobayashi, Motoko; Hosokawa, Takeshi; Fuke, Satoshi; Hasegawa, Masaru; Odajima, Nao; Moriyama, Chinatsu; Yoshida, Takayuki; Inomata, Takashi; Maki, Kanako; Shibuya, Eiji; Sasaki, Tsukasa; Nitta, Katsuaki; Yamamoto, Masafumi; Mizuno, Shigetaka; Miyamoto, Kenji; Hizawa, Nobuyuki.

In: International Journal of COPD, Vol. 10, 13.04.2015, p. 745-757.

Research output: Contribution to journalArticle

Nagai, K, Makita, H, Suzuki, M, Shimizu, K, Konno, S, Ito, YM, Nishimura, M, On behalf of the Hokkaido COPD Cohort Study Investigators, BOTHCOPDCSI, Kawakami, Y, Nishiura, Y, Saito, H, Kojima, T, Igarashi, T, Kimura, K, Nakano, I, Katabami, M, Itabashi, K, Morikawa, K, Tagami, S, Otsuka, Y, Sato, R, Kojima, J, Nigawara, S, Morioka, T, Sakai, I, Yamamoto, H, Ogura, S, Akie, K, Honmura, F, Kusudou, S, Izumi, H, Baba, K, Goya, H, Nakano, T, Takeyabu, K, Akiyama, Y, Kishi, F, Ito, A, Fujino, M, Ohe, M, Harada, T, Kamimura, A, Hakuma, N, Sukou, N, Takaoka, K, Doi, I, Ishimine, A, Nakano, R, Hasegawa, Y, Nasuhara, Y, Betsuyaku, T, Hamada, K, Ito, Y, Kobayashi, M, Hosokawa, T, Fuke, S, Hasegawa, M, Odajima, N, Moriyama, C, Yoshida, T, Inomata, T, Maki, K, Shibuya, E, Sasaki, T, Nitta, K, Yamamoto, M, Mizuno, S, Miyamoto, K & Hizawa, N 2015, 'Differential changes in quality of life components over 5 years in chronic obstructive pulmonary disease patients', International Journal of COPD, vol. 10, pp. 745-757. https://doi.org/10.2147/COPD.S77586
Nagai, Katsura ; Makita, Hironi ; Suzuki, Masaru ; Shimizu, Kaoruko ; Konno, Satoshi ; Ito, Yoichi M. ; Nishimura, Masaharu ; On behalf of the Hokkaido COPD Cohort Study Investigators, behalf of the Hokkaido COPD Cohort Study Investigators ; Kawakami, Yoshikazu ; Nishiura, Youichi ; Saito, Hiroshi ; Kojima, Tetsuya ; Igarashi, Takeshi ; Kimura, Kiyonobu ; Nakano, Ikuo ; Katabami, Moto ; Itabashi, Kouichi ; Morikawa, Kiyoshi ; Tagami, Seiichi ; Otsuka, Yoshihiro ; Sato, Rika ; Kojima, Junichiro ; Nigawara, Shinji ; Morioka, Takashi ; Sakai, Ichiro ; Yamamoto, Hiroshi ; Ogura, Shigeaki ; Akie, Kenji ; Honmura, Fumihiro ; Kusudou, Shinichi ; Izumi, Hiroshi ; Baba, Kensuke ; Goya, Hiroki ; Nakano, Tsuyoshi ; Takeyabu, Kimihiro ; Akiyama, Yasushi ; Kishi, Fujiya ; Ito, Akihide ; Fujino, Michihiro ; Ohe, Masashi ; Harada, Toshiyuki ; Kamimura, Akira ; Hakuma, Nobuyuki ; Sukou, Noriaki ; Takaoka, Kazuo ; Doi, Isamu ; Ishimine, Atsushi ; Nakano, Ryouji ; Hasegawa, Yasushi ; Nasuhara, Yasuyuki ; Betsuyaku, Tomoko ; Hamada, Kunio ; Ito, Yoko ; Kobayashi, Motoko ; Hosokawa, Takeshi ; Fuke, Satoshi ; Hasegawa, Masaru ; Odajima, Nao ; Moriyama, Chinatsu ; Yoshida, Takayuki ; Inomata, Takashi ; Maki, Kanako ; Shibuya, Eiji ; Sasaki, Tsukasa ; Nitta, Katsuaki ; Yamamoto, Masafumi ; Mizuno, Shigetaka ; Miyamoto, Kenji ; Hizawa, Nobuyuki. / Differential changes in quality of life components over 5 years in chronic obstructive pulmonary disease patients. In: International Journal of COPD. 2015 ; Vol. 10. pp. 745-757.
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T1 - Differential changes in quality of life components over 5 years in chronic obstructive pulmonary disease patients

AU - Nagai, Katsura

AU - Makita, Hironi

AU - Suzuki, Masaru

AU - Shimizu, Kaoruko

AU - Konno, Satoshi

AU - Ito, Yoichi M.

AU - Nishimura, Masaharu

AU - On behalf of the Hokkaido COPD Cohort Study Investigators, behalf of the Hokkaido COPD Cohort Study Investigators

AU - Kawakami, Yoshikazu

AU - Nishiura, Youichi

AU - Saito, Hiroshi

AU - Kojima, Tetsuya

AU - Igarashi, Takeshi

AU - Kimura, Kiyonobu

AU - Nakano, Ikuo

AU - Katabami, Moto

AU - Itabashi, Kouichi

AU - Morikawa, Kiyoshi

AU - Tagami, Seiichi

AU - Otsuka, Yoshihiro

AU - Sato, Rika

AU - Kojima, Junichiro

AU - Nigawara, Shinji

AU - Morioka, Takashi

AU - Sakai, Ichiro

AU - Yamamoto, Hiroshi

AU - Ogura, Shigeaki

AU - Akie, Kenji

AU - Honmura, Fumihiro

AU - Kusudou, Shinichi

AU - Izumi, Hiroshi

AU - Baba, Kensuke

AU - Goya, Hiroki

AU - Nakano, Tsuyoshi

AU - Takeyabu, Kimihiro

AU - Akiyama, Yasushi

AU - Kishi, Fujiya

AU - Ito, Akihide

AU - Fujino, Michihiro

AU - Ohe, Masashi

AU - Harada, Toshiyuki

AU - Kamimura, Akira

AU - Hakuma, Nobuyuki

AU - Sukou, Noriaki

AU - Takaoka, Kazuo

AU - Doi, Isamu

AU - Ishimine, Atsushi

AU - Nakano, Ryouji

AU - Hasegawa, Yasushi

AU - Nasuhara, Yasuyuki

AU - Betsuyaku, Tomoko

AU - Hamada, Kunio

AU - Ito, Yoko

AU - Kobayashi, Motoko

AU - Hosokawa, Takeshi

AU - Fuke, Satoshi

AU - Hasegawa, Masaru

AU - Odajima, Nao

AU - Moriyama, Chinatsu

AU - Yoshida, Takayuki

AU - Inomata, Takashi

AU - Maki, Kanako

AU - Shibuya, Eiji

AU - Sasaki, Tsukasa

AU - Nitta, Katsuaki

AU - Yamamoto, Masafumi

AU - Mizuno, Shigetaka

AU - Miyamoto, Kenji

AU - Hizawa, Nobuyuki

PY - 2015/4/13

Y1 - 2015/4/13

N2 - Background: The aim of the study was to examine the longitudinal change in quality of life components of patients with chronic obstructive pulmonary disease (COPD). Methods: In the Hokkaido COPD Cohort Study, 261 subjects were appropriately treated and followed over 5 years with a 74% follow-up rate at the end. The longitudinal changes in St George’s Respiratory Questionnaire (SGRQ) scores were annually evaluated with forced expiratory volume in 1 second (FEV1). The subjects were classified into the rapid decliners, slow decliners, and sustainers based on ΔFEV1/year. Results: The activity component of SGRQ generally deteriorated over time, and its annual decline was the greatest in the rapid decliners (<25th percentile). In contrast, the symptom component improved significantly year by year in the sustainers (>75 percentile), and it did not deteriorate even in the rapid decliners. Of the baseline data, predictors for worsening of the activity component were older age and lower body mass index. Larger reversibility was related to symptom component improvement. Of the follow-up data, ΔFEV1/year was the best predictor for worsening of the components of SGRQ. Continuous smoking was another factor for worsening of the activity component. For the symptom component, a history of exacerbation by admission definition was the determinant of its deterioration, whereas use of beta agonists was related to improvement. Conclusion: The longitudinal changes of quality of life and their determinants are markedly different and independent between its components. The activity component of SGRQ generally deteriorated over years, while the symptom component rather improved in some patients with COPD under appropriate treatment.

AB - Background: The aim of the study was to examine the longitudinal change in quality of life components of patients with chronic obstructive pulmonary disease (COPD). Methods: In the Hokkaido COPD Cohort Study, 261 subjects were appropriately treated and followed over 5 years with a 74% follow-up rate at the end. The longitudinal changes in St George’s Respiratory Questionnaire (SGRQ) scores were annually evaluated with forced expiratory volume in 1 second (FEV1). The subjects were classified into the rapid decliners, slow decliners, and sustainers based on ΔFEV1/year. Results: The activity component of SGRQ generally deteriorated over time, and its annual decline was the greatest in the rapid decliners (<25th percentile). In contrast, the symptom component improved significantly year by year in the sustainers (>75 percentile), and it did not deteriorate even in the rapid decliners. Of the baseline data, predictors for worsening of the activity component were older age and lower body mass index. Larger reversibility was related to symptom component improvement. Of the follow-up data, ΔFEV1/year was the best predictor for worsening of the components of SGRQ. Continuous smoking was another factor for worsening of the activity component. For the symptom component, a history of exacerbation by admission definition was the determinant of its deterioration, whereas use of beta agonists was related to improvement. Conclusion: The longitudinal changes of quality of life and their determinants are markedly different and independent between its components. The activity component of SGRQ generally deteriorated over years, while the symptom component rather improved in some patients with COPD under appropriate treatment.

KW - Annual change

KW - Exacerbation

KW - Forced expiratory volume in 1 second

KW - SGRQ

KW - Smoking

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