Differential contributions of prefrontal and hippocampal dopamine D 1 and D2 receptors in human cognitive functions

Hidehiko Takahashi, Motoichiro Kato, Harumasa Takano, Ryosuke Arakawa, Masaki Okumura, Tatsui Otsuka, Fumitoshi Kodaka, Mika Hayashi, Yoshiro Okubo, Hiroshi Ito, Tetsuya Suhara

Research output: Contribution to journalArticle

109 Citations (Scopus)

Abstract

Dopamine D1 receptors in the prefrontal cortex (PFC) are important for prefrontal functions, and it is suggested that stimulation of prefrontal D1 receptors induces an inverted U-shaped response, such that too little or too much D1 receptor stimulation impairs prefrontal functions. Less is known of the role of D2 receptors in cognition, but previous studies showed that D2 receptors in the hippocampus (HPC) might play some roles via HPC-PFC interactions.Wemeasured both D1 and D2 receptors in PFC and HPC using positron emission tomography in healthy subjects, with the aim of elucidating how regional D1 and D2 receptors are differentially involved in frontal lobe functions and memory. We found an inverted U-shaped relation between prefrontal D1 receptor binding and Wisconsin Card Sorting Test performance. However, prefrontal D2 binding has no relation with any neuropsychological measures. Hippocampal D2 receptor binding showed positive linear correlations not only with memory function but also with frontal lobe functions, but hippocampal D1 receptor binding had no association with any memory and prefrontal functions. Hippocampal D2 receptors seem to contribute to local hippocampal functions (long-term memory) and to modulation of brain functions outside HPC ("frontal lobe functions"), which are mainly subserved by PFC, via the HPC-PFC pathway. Our findings suggest that orchestration of prefrontal D1 receptors and hippocampal D2 receptors might be necessary for human executive function including working memory.

Original languageEnglish
Pages (from-to)12032-12038
Number of pages7
JournalJournal of Neuroscience
Volume28
Issue number46
DOIs
Publication statusPublished - 2008 Nov 12

Fingerprint

Prefrontal Cortex
Cognition
Hippocampus
Dopamine
Frontal Lobe
Dopamine D1 Receptors
Long-Term Memory
Executive Function
Short-Term Memory
Positron-Emission Tomography
Healthy Volunteers
Brain

Keywords

  • D receptors
  • D receptors
  • Dopamine
  • Hippocampus
  • Positron emission tomography
  • Prefrontal cortex

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Takahashi, H., Kato, M., Takano, H., Arakawa, R., Okumura, M., Otsuka, T., ... Suhara, T. (2008). Differential contributions of prefrontal and hippocampal dopamine D 1 and D2 receptors in human cognitive functions. Journal of Neuroscience, 28(46), 12032-12038. https://doi.org/10.1523/JNEUROSCI.3446-08.2008

Differential contributions of prefrontal and hippocampal dopamine D 1 and D2 receptors in human cognitive functions. / Takahashi, Hidehiko; Kato, Motoichiro; Takano, Harumasa; Arakawa, Ryosuke; Okumura, Masaki; Otsuka, Tatsui; Kodaka, Fumitoshi; Hayashi, Mika; Okubo, Yoshiro; Ito, Hiroshi; Suhara, Tetsuya.

In: Journal of Neuroscience, Vol. 28, No. 46, 12.11.2008, p. 12032-12038.

Research output: Contribution to journalArticle

Takahashi, H, Kato, M, Takano, H, Arakawa, R, Okumura, M, Otsuka, T, Kodaka, F, Hayashi, M, Okubo, Y, Ito, H & Suhara, T 2008, 'Differential contributions of prefrontal and hippocampal dopamine D 1 and D2 receptors in human cognitive functions', Journal of Neuroscience, vol. 28, no. 46, pp. 12032-12038. https://doi.org/10.1523/JNEUROSCI.3446-08.2008
Takahashi, Hidehiko ; Kato, Motoichiro ; Takano, Harumasa ; Arakawa, Ryosuke ; Okumura, Masaki ; Otsuka, Tatsui ; Kodaka, Fumitoshi ; Hayashi, Mika ; Okubo, Yoshiro ; Ito, Hiroshi ; Suhara, Tetsuya. / Differential contributions of prefrontal and hippocampal dopamine D 1 and D2 receptors in human cognitive functions. In: Journal of Neuroscience. 2008 ; Vol. 28, No. 46. pp. 12032-12038.
@article{f144ade9090c4ca194fa87a32718c9d6,
title = "Differential contributions of prefrontal and hippocampal dopamine D 1 and D2 receptors in human cognitive functions",
abstract = "Dopamine D1 receptors in the prefrontal cortex (PFC) are important for prefrontal functions, and it is suggested that stimulation of prefrontal D1 receptors induces an inverted U-shaped response, such that too little or too much D1 receptor stimulation impairs prefrontal functions. Less is known of the role of D2 receptors in cognition, but previous studies showed that D2 receptors in the hippocampus (HPC) might play some roles via HPC-PFC interactions.Wemeasured both D1 and D2 receptors in PFC and HPC using positron emission tomography in healthy subjects, with the aim of elucidating how regional D1 and D2 receptors are differentially involved in frontal lobe functions and memory. We found an inverted U-shaped relation between prefrontal D1 receptor binding and Wisconsin Card Sorting Test performance. However, prefrontal D2 binding has no relation with any neuropsychological measures. Hippocampal D2 receptor binding showed positive linear correlations not only with memory function but also with frontal lobe functions, but hippocampal D1 receptor binding had no association with any memory and prefrontal functions. Hippocampal D2 receptors seem to contribute to local hippocampal functions (long-term memory) and to modulation of brain functions outside HPC ({"}frontal lobe functions{"}), which are mainly subserved by PFC, via the HPC-PFC pathway. Our findings suggest that orchestration of prefrontal D1 receptors and hippocampal D2 receptors might be necessary for human executive function including working memory.",
keywords = "D receptors, D receptors, Dopamine, Hippocampus, Positron emission tomography, Prefrontal cortex",
author = "Hidehiko Takahashi and Motoichiro Kato and Harumasa Takano and Ryosuke Arakawa and Masaki Okumura and Tatsui Otsuka and Fumitoshi Kodaka and Mika Hayashi and Yoshiro Okubo and Hiroshi Ito and Tetsuya Suhara",
year = "2008",
month = "11",
day = "12",
doi = "10.1523/JNEUROSCI.3446-08.2008",
language = "English",
volume = "28",
pages = "12032--12038",
journal = "Journal of Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "46",

}

TY - JOUR

T1 - Differential contributions of prefrontal and hippocampal dopamine D 1 and D2 receptors in human cognitive functions

AU - Takahashi, Hidehiko

AU - Kato, Motoichiro

AU - Takano, Harumasa

AU - Arakawa, Ryosuke

AU - Okumura, Masaki

AU - Otsuka, Tatsui

AU - Kodaka, Fumitoshi

AU - Hayashi, Mika

AU - Okubo, Yoshiro

AU - Ito, Hiroshi

AU - Suhara, Tetsuya

PY - 2008/11/12

Y1 - 2008/11/12

N2 - Dopamine D1 receptors in the prefrontal cortex (PFC) are important for prefrontal functions, and it is suggested that stimulation of prefrontal D1 receptors induces an inverted U-shaped response, such that too little or too much D1 receptor stimulation impairs prefrontal functions. Less is known of the role of D2 receptors in cognition, but previous studies showed that D2 receptors in the hippocampus (HPC) might play some roles via HPC-PFC interactions.Wemeasured both D1 and D2 receptors in PFC and HPC using positron emission tomography in healthy subjects, with the aim of elucidating how regional D1 and D2 receptors are differentially involved in frontal lobe functions and memory. We found an inverted U-shaped relation between prefrontal D1 receptor binding and Wisconsin Card Sorting Test performance. However, prefrontal D2 binding has no relation with any neuropsychological measures. Hippocampal D2 receptor binding showed positive linear correlations not only with memory function but also with frontal lobe functions, but hippocampal D1 receptor binding had no association with any memory and prefrontal functions. Hippocampal D2 receptors seem to contribute to local hippocampal functions (long-term memory) and to modulation of brain functions outside HPC ("frontal lobe functions"), which are mainly subserved by PFC, via the HPC-PFC pathway. Our findings suggest that orchestration of prefrontal D1 receptors and hippocampal D2 receptors might be necessary for human executive function including working memory.

AB - Dopamine D1 receptors in the prefrontal cortex (PFC) are important for prefrontal functions, and it is suggested that stimulation of prefrontal D1 receptors induces an inverted U-shaped response, such that too little or too much D1 receptor stimulation impairs prefrontal functions. Less is known of the role of D2 receptors in cognition, but previous studies showed that D2 receptors in the hippocampus (HPC) might play some roles via HPC-PFC interactions.Wemeasured both D1 and D2 receptors in PFC and HPC using positron emission tomography in healthy subjects, with the aim of elucidating how regional D1 and D2 receptors are differentially involved in frontal lobe functions and memory. We found an inverted U-shaped relation between prefrontal D1 receptor binding and Wisconsin Card Sorting Test performance. However, prefrontal D2 binding has no relation with any neuropsychological measures. Hippocampal D2 receptor binding showed positive linear correlations not only with memory function but also with frontal lobe functions, but hippocampal D1 receptor binding had no association with any memory and prefrontal functions. Hippocampal D2 receptors seem to contribute to local hippocampal functions (long-term memory) and to modulation of brain functions outside HPC ("frontal lobe functions"), which are mainly subserved by PFC, via the HPC-PFC pathway. Our findings suggest that orchestration of prefrontal D1 receptors and hippocampal D2 receptors might be necessary for human executive function including working memory.

KW - D receptors

KW - D receptors

KW - Dopamine

KW - Hippocampus

KW - Positron emission tomography

KW - Prefrontal cortex

UR - http://www.scopus.com/inward/record.url?scp=58149326818&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=58149326818&partnerID=8YFLogxK

U2 - 10.1523/JNEUROSCI.3446-08.2008

DO - 10.1523/JNEUROSCI.3446-08.2008

M3 - Article

C2 - 19005068

AN - SCOPUS:58149326818

VL - 28

SP - 12032

EP - 12038

JO - Journal of Neuroscience

JF - Journal of Neuroscience

SN - 0270-6474

IS - 46

ER -