Differential diagnosis of small cell glioblastoma and anaplastic oligodendroglioma: A case report of an elderly man

Kenta Takahashi, Masumi Tsuda, Hiromi Kanno, Junichi Murata, Roshan Mahabir, Yusuke Ishida, Taichi Kimura, Mishie Tanino, Hiroshi Nishihara, Kazuo Nagashima, Shinya Tanaka

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Small cell glioblastoma is a histological subtype of glioblastoma with characteristic features of highly proliferative, monotonous small glial cells with high nuclear cytoplasm ratio. Morphologically, malignant lymphoma or small cell metastatic carcinoma should be carefully discriminated. Some cases are difficult to differentiate from anaplastic oligodendroglioma. In this report, we present a case of small cell glioblastoma of an elderly man. The lack of IDH1/2 mutation was confirmed by immunohistochemistry and direct sequencing. Fluorescence in situ hybridization revealed the lower rates of chromosome 1p and 19q deletion. Microsatellite analysis disclosed partial 10q alteration near the PTEN locus. Not only morphological and immunohistochemical examinations, but also cytogenetical investigations for IDH1/2 mutation, 1p/19q loss, and PTEN alteration, are strongly supportive methods for the differential diagnosis of small cell glioblastoma and anaplastic oligodendroglioma.

Original languageEnglish
Pages (from-to)118-123
Number of pages6
JournalBrain tumor pathology
Volume31
Issue number2
DOIs
Publication statusPublished - 2014 Jan 1
Externally publishedYes

Fingerprint

Oligodendroglioma
Glioblastoma
Differential Diagnosis
Mutation
Small Cell Carcinoma
Fluorescence In Situ Hybridization
Neuroglia
Microsatellite Repeats
Lymphoma
Cytoplasm
Chromosomes
Immunohistochemistry

Keywords

  • 1p/19q loss
  • Anaplastic oligodendroglioma
  • IDH1 mutation
  • PTEN alteration
  • Small cell glioblastoma

ASJC Scopus subject areas

  • Oncology
  • Clinical Neurology
  • Cancer Research

Cite this

Differential diagnosis of small cell glioblastoma and anaplastic oligodendroglioma : A case report of an elderly man. / Takahashi, Kenta; Tsuda, Masumi; Kanno, Hiromi; Murata, Junichi; Mahabir, Roshan; Ishida, Yusuke; Kimura, Taichi; Tanino, Mishie; Nishihara, Hiroshi; Nagashima, Kazuo; Tanaka, Shinya.

In: Brain tumor pathology, Vol. 31, No. 2, 01.01.2014, p. 118-123.

Research output: Contribution to journalArticle

Takahashi, K, Tsuda, M, Kanno, H, Murata, J, Mahabir, R, Ishida, Y, Kimura, T, Tanino, M, Nishihara, H, Nagashima, K & Tanaka, S 2014, 'Differential diagnosis of small cell glioblastoma and anaplastic oligodendroglioma: A case report of an elderly man', Brain tumor pathology, vol. 31, no. 2, pp. 118-123. https://doi.org/10.1007/s10014-013-0158-9
Takahashi, Kenta ; Tsuda, Masumi ; Kanno, Hiromi ; Murata, Junichi ; Mahabir, Roshan ; Ishida, Yusuke ; Kimura, Taichi ; Tanino, Mishie ; Nishihara, Hiroshi ; Nagashima, Kazuo ; Tanaka, Shinya. / Differential diagnosis of small cell glioblastoma and anaplastic oligodendroglioma : A case report of an elderly man. In: Brain tumor pathology. 2014 ; Vol. 31, No. 2. pp. 118-123.
@article{1c2ba202c50b495b978a4f35d5d46496,
title = "Differential diagnosis of small cell glioblastoma and anaplastic oligodendroglioma: A case report of an elderly man",
abstract = "Small cell glioblastoma is a histological subtype of glioblastoma with characteristic features of highly proliferative, monotonous small glial cells with high nuclear cytoplasm ratio. Morphologically, malignant lymphoma or small cell metastatic carcinoma should be carefully discriminated. Some cases are difficult to differentiate from anaplastic oligodendroglioma. In this report, we present a case of small cell glioblastoma of an elderly man. The lack of IDH1/2 mutation was confirmed by immunohistochemistry and direct sequencing. Fluorescence in situ hybridization revealed the lower rates of chromosome 1p and 19q deletion. Microsatellite analysis disclosed partial 10q alteration near the PTEN locus. Not only morphological and immunohistochemical examinations, but also cytogenetical investigations for IDH1/2 mutation, 1p/19q loss, and PTEN alteration, are strongly supportive methods for the differential diagnosis of small cell glioblastoma and anaplastic oligodendroglioma.",
keywords = "1p/19q loss, Anaplastic oligodendroglioma, IDH1 mutation, PTEN alteration, Small cell glioblastoma",
author = "Kenta Takahashi and Masumi Tsuda and Hiromi Kanno and Junichi Murata and Roshan Mahabir and Yusuke Ishida and Taichi Kimura and Mishie Tanino and Hiroshi Nishihara and Kazuo Nagashima and Shinya Tanaka",
year = "2014",
month = "1",
day = "1",
doi = "10.1007/s10014-013-0158-9",
language = "English",
volume = "31",
pages = "118--123",
journal = "Brain Tumor Pathology",
issn = "1433-7398",
publisher = "Springer Japan",
number = "2",

}

TY - JOUR

T1 - Differential diagnosis of small cell glioblastoma and anaplastic oligodendroglioma

T2 - A case report of an elderly man

AU - Takahashi, Kenta

AU - Tsuda, Masumi

AU - Kanno, Hiromi

AU - Murata, Junichi

AU - Mahabir, Roshan

AU - Ishida, Yusuke

AU - Kimura, Taichi

AU - Tanino, Mishie

AU - Nishihara, Hiroshi

AU - Nagashima, Kazuo

AU - Tanaka, Shinya

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Small cell glioblastoma is a histological subtype of glioblastoma with characteristic features of highly proliferative, monotonous small glial cells with high nuclear cytoplasm ratio. Morphologically, malignant lymphoma or small cell metastatic carcinoma should be carefully discriminated. Some cases are difficult to differentiate from anaplastic oligodendroglioma. In this report, we present a case of small cell glioblastoma of an elderly man. The lack of IDH1/2 mutation was confirmed by immunohistochemistry and direct sequencing. Fluorescence in situ hybridization revealed the lower rates of chromosome 1p and 19q deletion. Microsatellite analysis disclosed partial 10q alteration near the PTEN locus. Not only morphological and immunohistochemical examinations, but also cytogenetical investigations for IDH1/2 mutation, 1p/19q loss, and PTEN alteration, are strongly supportive methods for the differential diagnosis of small cell glioblastoma and anaplastic oligodendroglioma.

AB - Small cell glioblastoma is a histological subtype of glioblastoma with characteristic features of highly proliferative, monotonous small glial cells with high nuclear cytoplasm ratio. Morphologically, malignant lymphoma or small cell metastatic carcinoma should be carefully discriminated. Some cases are difficult to differentiate from anaplastic oligodendroglioma. In this report, we present a case of small cell glioblastoma of an elderly man. The lack of IDH1/2 mutation was confirmed by immunohistochemistry and direct sequencing. Fluorescence in situ hybridization revealed the lower rates of chromosome 1p and 19q deletion. Microsatellite analysis disclosed partial 10q alteration near the PTEN locus. Not only morphological and immunohistochemical examinations, but also cytogenetical investigations for IDH1/2 mutation, 1p/19q loss, and PTEN alteration, are strongly supportive methods for the differential diagnosis of small cell glioblastoma and anaplastic oligodendroglioma.

KW - 1p/19q loss

KW - Anaplastic oligodendroglioma

KW - IDH1 mutation

KW - PTEN alteration

KW - Small cell glioblastoma

UR - http://www.scopus.com/inward/record.url?scp=84899910809&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84899910809&partnerID=8YFLogxK

U2 - 10.1007/s10014-013-0158-9

DO - 10.1007/s10014-013-0158-9

M3 - Article

C2 - 23979650

AN - SCOPUS:84899910809

VL - 31

SP - 118

EP - 123

JO - Brain Tumor Pathology

JF - Brain Tumor Pathology

SN - 1433-7398

IS - 2

ER -