Abstract
B cell-activating factor belonging to the tumor necrosis factor superfamily (BAFF) is a crucial factor for B cell development and is involved in the survival of malignant B cells, but its effect on B cell precursors (BCPs) remains unclear. We investigated BCP acute lymphoblastic leukemia (-ALL) cells for BAFF receptor (-R) expression and compared the effect of BAFF on BCP-ALL cells and Burkitt lymphoma (BL) cells. Expression of BAFF-R was detected in some cell lines and some clinical specimens of both BL and BCP-ALL. BAFF acted on both BL and BCP-ALL cells and promoted proliferation by both. BAFF also inhibited apoptosis by BL cells induced by cross-linking of cell surface molecules and anticancer drugs, but failed to inhibit apoptosis by BCP-ALL cells. BAFF induced prompt and obvious activation of the NF-κB signaling pathway in BL cells, but only weak and delayed activation of the pathway in BCP-ALL cells. The results of this study indicate that some BCP-ALL cells and some BL cells express BAFF-R, but that the effects of BAFF on BCP-ALL cells are different from its effects on mature B cell malignancies.
| Original language | English |
|---|---|
| Pages (from-to) | 808-819 |
| Number of pages | 12 |
| Journal | International Journal of Hematology |
| Volume | 91 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2010 Jun |
| Externally published | Yes |
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Keywords
- Apoptosis
- B cell precursor ALL
- BAFF
- Burkitt lymphoma
ASJC Scopus subject areas
- Hematology
- Medicine(all)
Cite this
Differential effects of BAFF on B cell precursor acute lymphoblastic leukemia and Burkitt lymphoma. / Onda, Keiko; Iijima, Kazutoshi; Katagiri, Yohko U.; Okita, Hajime; Saito, Masahiro; Shimizu, Toshiaki; Kiyokawa, Nobutaka.
In: International Journal of Hematology, Vol. 91, No. 5, 06.2010, p. 808-819.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Differential effects of BAFF on B cell precursor acute lymphoblastic leukemia and Burkitt lymphoma
AU - Onda, Keiko
AU - Iijima, Kazutoshi
AU - Katagiri, Yohko U.
AU - Okita, Hajime
AU - Saito, Masahiro
AU - Shimizu, Toshiaki
AU - Kiyokawa, Nobutaka
PY - 2010/6
Y1 - 2010/6
N2 - B cell-activating factor belonging to the tumor necrosis factor superfamily (BAFF) is a crucial factor for B cell development and is involved in the survival of malignant B cells, but its effect on B cell precursors (BCPs) remains unclear. We investigated BCP acute lymphoblastic leukemia (-ALL) cells for BAFF receptor (-R) expression and compared the effect of BAFF on BCP-ALL cells and Burkitt lymphoma (BL) cells. Expression of BAFF-R was detected in some cell lines and some clinical specimens of both BL and BCP-ALL. BAFF acted on both BL and BCP-ALL cells and promoted proliferation by both. BAFF also inhibited apoptosis by BL cells induced by cross-linking of cell surface molecules and anticancer drugs, but failed to inhibit apoptosis by BCP-ALL cells. BAFF induced prompt and obvious activation of the NF-κB signaling pathway in BL cells, but only weak and delayed activation of the pathway in BCP-ALL cells. The results of this study indicate that some BCP-ALL cells and some BL cells express BAFF-R, but that the effects of BAFF on BCP-ALL cells are different from its effects on mature B cell malignancies.
AB - B cell-activating factor belonging to the tumor necrosis factor superfamily (BAFF) is a crucial factor for B cell development and is involved in the survival of malignant B cells, but its effect on B cell precursors (BCPs) remains unclear. We investigated BCP acute lymphoblastic leukemia (-ALL) cells for BAFF receptor (-R) expression and compared the effect of BAFF on BCP-ALL cells and Burkitt lymphoma (BL) cells. Expression of BAFF-R was detected in some cell lines and some clinical specimens of both BL and BCP-ALL. BAFF acted on both BL and BCP-ALL cells and promoted proliferation by both. BAFF also inhibited apoptosis by BL cells induced by cross-linking of cell surface molecules and anticancer drugs, but failed to inhibit apoptosis by BCP-ALL cells. BAFF induced prompt and obvious activation of the NF-κB signaling pathway in BL cells, but only weak and delayed activation of the pathway in BCP-ALL cells. The results of this study indicate that some BCP-ALL cells and some BL cells express BAFF-R, but that the effects of BAFF on BCP-ALL cells are different from its effects on mature B cell malignancies.
KW - Apoptosis
KW - B cell precursor ALL
KW - BAFF
KW - Burkitt lymphoma
UR - http://www.scopus.com/inward/record.url?scp=77954533012&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77954533012&partnerID=8YFLogxK
U2 - 10.1007/s12185-010-0567-z
DO - 10.1007/s12185-010-0567-z
M3 - Article
C2 - 20428981
AN - SCOPUS:77954533012
VL - 91
SP - 808
EP - 819
JO - International Journal of Hematology
JF - International Journal of Hematology
SN - 0925-5710
IS - 5
ER -