Differential effects of BAFF on B cell precursor acute lymphoblastic leukemia and Burkitt lymphoma

Keiko Onda, Kazutoshi Iijima, Yohko U. Katagiri, Hajime Okita, Masahiro Saito, Toshiaki Shimizu, Nobutaka Kiyokawa

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

B cell-activating factor belonging to the tumor necrosis factor superfamily (BAFF) is a crucial factor for B cell development and is involved in the survival of malignant B cells, but its effect on B cell precursors (BCPs) remains unclear. We investigated BCP acute lymphoblastic leukemia (-ALL) cells for BAFF receptor (-R) expression and compared the effect of BAFF on BCP-ALL cells and Burkitt lymphoma (BL) cells. Expression of BAFF-R was detected in some cell lines and some clinical specimens of both BL and BCP-ALL. BAFF acted on both BL and BCP-ALL cells and promoted proliferation by both. BAFF also inhibited apoptosis by BL cells induced by cross-linking of cell surface molecules and anticancer drugs, but failed to inhibit apoptosis by BCP-ALL cells. BAFF induced prompt and obvious activation of the NF-κB signaling pathway in BL cells, but only weak and delayed activation of the pathway in BCP-ALL cells. The results of this study indicate that some BCP-ALL cells and some BL cells express BAFF-R, but that the effects of BAFF on BCP-ALL cells are different from its effects on mature B cell malignancies.

Original languageEnglish
Pages (from-to)808-819
Number of pages12
JournalInternational journal of hematology
Volume91
Issue number5
DOIs
Publication statusPublished - 2010 Jun 1
Externally publishedYes

Keywords

  • Apoptosis
  • B cell precursor ALL
  • BAFF
  • Burkitt lymphoma

ASJC Scopus subject areas

  • Hematology

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