Differential expression of an orphan receptor COUP-TFI and corepressors in adrenal tumors

Hirotaka Shibata, Takashi Ando, Toshihiko Suzuki, Isao Kurihara, Kouichi Hayashi, Matsuhiko Hayashi, Ikuo Saito, Hiroshi Kawabe, Minako Tsujioka, Masaru Mural, Takao Saruta

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Abstract

Recently, it has been shown that CYP17 gene transcription is activated by SF-1 (Steroidogenic Factor-1) binding to a cyclic AMP-responsive sequence within the promoter region of the gene, whereas it is inhibited by COUP-TF (Chicken Ovalbumin Upstream Promoter-Transcription Factor) binding to the sequence. We have shown that transcriptional repression by COUP-TFI is mediated by corepressors, N-CoR (nuclear receptor corepressor) and SMRT (silencing mediator for retinoid and thyroid hormone-receptor). Therefore, we compared the expression of COUP-TFI, N-CoR and SMRT in non-hyperfunctioning adrenocortical adenomas and normal adrenal glands. We found significantly higher expression of COUP-TFI mRNA in non-hyperfunctioning adenomas (n=5, 227±18%) than in normal adrenals (n=5, 96±4%). Interestingly, the pattern of N-CoR and SMRT expression was different compared with COUP-TFI expression. These data suggest that COUP-TFI, N-CoR, and SMRT may play a differential role in steroid biosynthesis of non-hyperfunctioning adenomas.

Original languageEnglish
Pages (from-to)881-885
Number of pages5
JournalEndocrine Research
Volume24
Issue number3-4
DOIs
Publication statusPublished - 1998 Jan 1

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ASJC Scopus subject areas

  • Endocrinology

Cite this

Shibata, H., Ando, T., Suzuki, T., Kurihara, I., Hayashi, K., Hayashi, M., Saito, I., Kawabe, H., Tsujioka, M., Mural, M., & Saruta, T. (1998). Differential expression of an orphan receptor COUP-TFI and corepressors in adrenal tumors. Endocrine Research, 24(3-4), 881-885. https://doi.org/10.3109/07435809809032703