Differential expression of MART-1 in primary and metastatic melanoma lesions

Toshiro Kageshita, Yutaka Kawakami, Shunji Hirai, Tomomichi Ono

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44 Citations (Scopus)

Abstract

Twenty-eight primary and 29 metastatic melanoma lesions and 18 pigmented nevi lesions were analyzed by using the immunoperoxidase reaction with anti-MART-1 and anti-gp100 monoclonal antibodies (mAbs). The MART-1 was expressed in 28, 29, and 18, and gp100 was expressed in 27, 28, and eight of these lesions, respectively. Intensity and percentage of stained cells with anti-MART-1 mAb were stronger and higher than those with anti-gp100 mAb. MART-1 was expressed homogeneously in primary melanoma and pigmented nevi, whereas it was heterogeneously expressed in metastatic melanoma lesions. The level of expression of MART-1 in primary melanoma lesions did not correlate with any clinicopathologic parameters. These results suggest that anti-MART-1 mAb is a useful tool for immunohistochemical analysis of melanocytic lesions and also is useful for patient’s selection and monitoring of antigen-loss variants in clinical trials with the MART-1-based immunotherapy.

Original languageEnglish
Pages (from-to)460-465
Number of pages6
JournalJournal of Immunotherapy
Volume20
Issue number6
DOIs
Publication statusPublished - 1997 Jan 1

Keywords

  • GP100
  • MART-1
  • Melanocytic tumor

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology
  • Cancer Research

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