Differential expression of WNTs and FRPs in the synovium of rheumatoid arthritis and osteoarthritis

Kazushi Imai, Masako Morikawa, Jeanine D'Armiento, Hideo Matsumoto, Koichiro Komiya, Yasunori Okada

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Synovial cells of the joint play a key role in the progression of rheumatoid arthritis (RA). However, the mechanism(s) that triggers aggression of RA synovial cells but not other arthropathies such as osteoarthritis (OA) is not clear. Here we examined expression of WNT and the WNT inhibitor, secreted frizzled-related protein (FRP), in RA and OA synovium by reverse transcription-PCR. WNT10B was most frequently detected in RA synovium, and FRP1, FRP2, and FRP4 in OA synovium. Immunohistochemistry localized WNT10B and FRP1 in synovial lining cells, fibroblasts, and endothelial cells in RA and OA synovium, respectively, and WNT10B expression was increased in parallel with the degree of inflammatory cell infiltration and tissue fibrosis. Membrane-type 1 matrix metalloproteinse (MT1MMP) was upregulated by WNT10B and activation of WNT signaling. MT1MMP immunolocalized to cells identical to WNT10B and β-catenin staining. The present study demonstrated that WNTs and FRPs are differentially expressed in RA and OA synovium, and suggests an involvement in the pathology of these diseases.

Original languageEnglish
Pages (from-to)1615-1620
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume345
Issue number4
DOIs
Publication statusPublished - 2006 Jul 14

Keywords

  • Arthritis
  • FRP
  • Osteoarthritis
  • Rheumatoid arthritis
  • Synovium
  • WNT
  • β-Catenin

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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