TY - JOUR
T1 - Differential expression pattern of XqPAR-linked genes SYBL1 and IL9R correlates with the structure and evolution of the region
AU - D'Esposito, Maurizio
AU - Matarazzo, Maria Rosaria
AU - Ciccodicola, Alfredo
AU - Strazzullo, Maria
AU - Mazzarella, Richard
AU - Quaderi, Nandita A.
AU - Fujiwara, Hiroyuki
AU - Ko, Minoru S.H.
AU - Rowe, Lucy B.
AU - Ricco, Angela
AU - Archidiacono, Nicoletta
AU - Rocchi, Mariano
AU - Schlessinger, David
AU - D'Urso, Michele
N1 - Funding Information:
The authors gratefully acknowledge Professor R. Dulbecco for critical reading of the manuscript, Drs G. Persico, M. Di Giulio and S. Mumm for helpful comments, Drs T. Featherstone, F. Gianfrancesco, T. Esposito and M. Chiurazzi for help in the initial part of the work, Mrs M. and Mr A. Terracciano for their technical assistance and C. Bouchcinsky for her secretarial assistance. Also to the memory of G. Blasi for his continuing assistance and to whom this manuscript is dedicated. This work is supported by grants from Telethon-Italy (E.526) and EC contract BMH4-CT96-1134 to M.D’U. and by grants from the Italian Association for Cancer Research (AIRC) and from Telethon-Italy to M.R. N.A.Q. is funded by a TMR post-doctoral fellowship (ERBFMBICT960649) from the EU. L.B.R. and The Jackson Laboratory interspecific backcross mapping resource are supported by a grant from the NCHGR (HG00941). This work was also supported in part by a NIH (USA) grant (HD32243) to M.S.H.K and HG00247 to D.S.
PY - 1997/10
Y1 - 1997/10
N2 - The recently discovered second pseudoautosomal region (XqPAR) contains at least two genes, IL9R and SYBL1. Recent findings show that, like XpPAR genes, IL9R escapes X inactivation and its Y allele is also expressed, but SYBL1 seems to act like an X-linked gene, expressed from the active X chromosome but not from the inactive X or Y. Here we show that differences are also seen in the evolution of the sex chromosome locations of IL9R and SYBL1, IL9R is known to be autosomal in mice, and is X-linked only in primates. SYBL1, however, has been found to be on the X chromosome in all mammals tested, from marsupials to humans. Both genes were duplicated on the Y homologue of the terminal portion of the X chromosome during the evolution of Homo sapiens from other higher primates. The inactivation pattern of SYBL1 may be correlated with its longer history of X linkage, and at a more centromeric chromosomal position during evolution; the more recent X linkage and more telomeric position of the IL9R gene may explain its autosomal, 'uninactivated' transcriptional status.
AB - The recently discovered second pseudoautosomal region (XqPAR) contains at least two genes, IL9R and SYBL1. Recent findings show that, like XpPAR genes, IL9R escapes X inactivation and its Y allele is also expressed, but SYBL1 seems to act like an X-linked gene, expressed from the active X chromosome but not from the inactive X or Y. Here we show that differences are also seen in the evolution of the sex chromosome locations of IL9R and SYBL1, IL9R is known to be autosomal in mice, and is X-linked only in primates. SYBL1, however, has been found to be on the X chromosome in all mammals tested, from marsupials to humans. Both genes were duplicated on the Y homologue of the terminal portion of the X chromosome during the evolution of Homo sapiens from other higher primates. The inactivation pattern of SYBL1 may be correlated with its longer history of X linkage, and at a more centromeric chromosomal position during evolution; the more recent X linkage and more telomeric position of the IL9R gene may explain its autosomal, 'uninactivated' transcriptional status.
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U2 - 10.1093/hmg/6.11.1917
DO - 10.1093/hmg/6.11.1917
M3 - Article
C2 - 9302271
AN - SCOPUS:9844267306
VL - 6
SP - 1917
EP - 1923
JO - Human Molecular Genetics
JF - Human Molecular Genetics
SN - 0964-6906
IS - 11
ER -