Abstract
The recently discovered second pseudoautosomal region (XqPAR) contains at least two genes, IL9R and SYBL1. Recent findings show that, like XpPAR genes, IL9R escapes X inactivation and its Y allele is also expressed, but SYBL1 seems to act like an X-linked gene, expressed from the active X chromosome but not from the inactive X or Y. Here we show that differences are also seen in the evolution of the sex chromosome locations of IL9R and SYBL1, IL9R is known to be autosomal in mice, and is X-linked only in primates. SYBL1, however, has been found to be on the X chromosome in all mammals tested, from marsupials to humans. Both genes were duplicated on the Y homologue of the terminal portion of the X chromosome during the evolution of Homo sapiens from other higher primates. The inactivation pattern of SYBL1 may be correlated with its longer history of X linkage, and at a more centromeric chromosomal position during evolution; the more recent X linkage and more telomeric position of the IL9R gene may explain its autosomal, 'uninactivated' transcriptional status.
| Original language | English |
|---|---|
| Pages (from-to) | 1917-1923 |
| Number of pages | 7 |
| Journal | Human Molecular Genetics |
| Volume | 6 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 1997 Oct |
| Externally published | Yes |
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ASJC Scopus subject areas
- Genetics
Cite this
Differential expression pattern of XqPAR-linked genes SYBL1 and IL9R correlates with the structure and evolution of the region. / D'Esposito, Maurizio; Matarazzo, Maria Rosaria; Ciccodicola, Alfredo; Strazzullo, Maria; Mazzarella, Richard; Quaderi, Nandita A.; Fujiwara, Hiroyuki; Ko, Minoru; Rowe, Lucy B.; Ricco, Angela; Archidiacono, Nicoletta; Rocchi, Mariano; Schlessinger, David; D'Urso, Michele.
In: Human Molecular Genetics, Vol. 6, No. 11, 10.1997, p. 1917-1923.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Differential expression pattern of XqPAR-linked genes SYBL1 and IL9R correlates with the structure and evolution of the region
AU - D'Esposito, Maurizio
AU - Matarazzo, Maria Rosaria
AU - Ciccodicola, Alfredo
AU - Strazzullo, Maria
AU - Mazzarella, Richard
AU - Quaderi, Nandita A.
AU - Fujiwara, Hiroyuki
AU - Ko, Minoru
AU - Rowe, Lucy B.
AU - Ricco, Angela
AU - Archidiacono, Nicoletta
AU - Rocchi, Mariano
AU - Schlessinger, David
AU - D'Urso, Michele
PY - 1997/10
Y1 - 1997/10
N2 - The recently discovered second pseudoautosomal region (XqPAR) contains at least two genes, IL9R and SYBL1. Recent findings show that, like XpPAR genes, IL9R escapes X inactivation and its Y allele is also expressed, but SYBL1 seems to act like an X-linked gene, expressed from the active X chromosome but not from the inactive X or Y. Here we show that differences are also seen in the evolution of the sex chromosome locations of IL9R and SYBL1, IL9R is known to be autosomal in mice, and is X-linked only in primates. SYBL1, however, has been found to be on the X chromosome in all mammals tested, from marsupials to humans. Both genes were duplicated on the Y homologue of the terminal portion of the X chromosome during the evolution of Homo sapiens from other higher primates. The inactivation pattern of SYBL1 may be correlated with its longer history of X linkage, and at a more centromeric chromosomal position during evolution; the more recent X linkage and more telomeric position of the IL9R gene may explain its autosomal, 'uninactivated' transcriptional status.
AB - The recently discovered second pseudoautosomal region (XqPAR) contains at least two genes, IL9R and SYBL1. Recent findings show that, like XpPAR genes, IL9R escapes X inactivation and its Y allele is also expressed, but SYBL1 seems to act like an X-linked gene, expressed from the active X chromosome but not from the inactive X or Y. Here we show that differences are also seen in the evolution of the sex chromosome locations of IL9R and SYBL1, IL9R is known to be autosomal in mice, and is X-linked only in primates. SYBL1, however, has been found to be on the X chromosome in all mammals tested, from marsupials to humans. Both genes were duplicated on the Y homologue of the terminal portion of the X chromosome during the evolution of Homo sapiens from other higher primates. The inactivation pattern of SYBL1 may be correlated with its longer history of X linkage, and at a more centromeric chromosomal position during evolution; the more recent X linkage and more telomeric position of the IL9R gene may explain its autosomal, 'uninactivated' transcriptional status.
UR - http://www.scopus.com/inward/record.url?scp=9844267306&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=9844267306&partnerID=8YFLogxK
U2 - 10.1093/hmg/6.11.1917
DO - 10.1093/hmg/6.11.1917
M3 - Article
C2 - 9302271
AN - SCOPUS:9844267306
VL - 6
SP - 1917
EP - 1923
JO - Human Molecular Genetics
JF - Human Molecular Genetics
SN - 0964-6906
IS - 11
ER -