Differential Localization of Alternative Spliced Transcripts Encoding Inositol 1,4,5‐Trisphosphate Receptors in Mouse Cerebellum and Hippocampus: In Situ Hybridization Study

Toshiyuki Nakagawa, Chiyo Shiota, Hideyuki Okano, Katsuhiko Mikoshiba

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

: Expression of inositol 1,4,5‐trisphosphate (InsP3) receptor subtypes was determined in mouse brain using oligonucleotide‐specific in situ hybridization. All subtypes, except one that deletes 120 bp from the full‐length InsP3 receptor cDNA, were expressed in cerebellar Purkinje cells. In hippocampus, various subtypes showed distinct expression patterns. These results suggest that regionally selective expression of InsP3 receptor subtypes may result in the generation of functionally distinct channels.

Original languageEnglish
Pages (from-to)1807-1810
Number of pages4
JournalJournal of Neurochemistry
Volume57
Issue number5
DOIs
Publication statusPublished - 1991 Nov
Externally publishedYes

Keywords

  • Alternative splicing
  • Cerebellum
  • Hippocampus
  • In situ hybridization
  • Inositol 1,4,5‐trisphosphate receptor
  • Mouse brain
  • Purkinje cell

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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