Abstract
IL-17-producing CD4+ T cells, so called Th17 cells, constitute a newly identified inflammatogenic cell population, which is critically involved in some inflammatory diseases. To explore the role of Th17 cells in murine experimental autoimmune uveoretinitis (EAU), a model of human autoimmune uveitis where Th1 responses predominantly participate in the pathogenesis, IL-17- mice were immunized with interphotoreceptor retinoid-binding protein peptide 1-20 for disease induction. Funduscopic examination revealed that EAU was induced in IL-17- mice just like in wild-type (WT) mice at early phases of the disease. However, at later/maintenance phases, the severity was significantly reduced in IL-17- mice. Expression of IFN-γ and MCP-1 was comparable between WT and IL-17- mice during the time course. In vivo blockade of IFN-γ and IL-4 resulted in exacerbation of EAU at later phases with augmented IL-17 production. Taken together, our data demonstrated that IL-17/Th17 participates in the late phases of EAU and also that Th1 and Th17 responses are differentially required for EAU.
| Original language | English |
|---|---|
| Pages (from-to) | 209-214 |
| Number of pages | 6 |
| Journal | International Immunology |
| Volume | 20 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2008 Feb |
| Externally published | Yes |
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Keywords
- Autoimmunity
- Cytokines
- Inflammation
- T1
- T17
ASJC Scopus subject areas
- Immunology
Cite this
Differential roles for IFN-γ and IL-17 in experimental autoimmune uveoretinitis. / Yoshimura, Takeru; Sonoda, Koh Hei; Miyazaki, Yoshiyuki; Iwakura, Yoichiro; Ishibashi, Tatsuro; Yoshimura, Akihiko; Yoshida, Hiroki.
In: International Immunology, Vol. 20, No. 2, 02.2008, p. 209-214.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Differential roles for IFN-γ and IL-17 in experimental autoimmune uveoretinitis
AU - Yoshimura, Takeru
AU - Sonoda, Koh Hei
AU - Miyazaki, Yoshiyuki
AU - Iwakura, Yoichiro
AU - Ishibashi, Tatsuro
AU - Yoshimura, Akihiko
AU - Yoshida, Hiroki
PY - 2008/2
Y1 - 2008/2
N2 - IL-17-producing CD4+ T cells, so called Th17 cells, constitute a newly identified inflammatogenic cell population, which is critically involved in some inflammatory diseases. To explore the role of Th17 cells in murine experimental autoimmune uveoretinitis (EAU), a model of human autoimmune uveitis where Th1 responses predominantly participate in the pathogenesis, IL-17- mice were immunized with interphotoreceptor retinoid-binding protein peptide 1-20 for disease induction. Funduscopic examination revealed that EAU was induced in IL-17- mice just like in wild-type (WT) mice at early phases of the disease. However, at later/maintenance phases, the severity was significantly reduced in IL-17- mice. Expression of IFN-γ and MCP-1 was comparable between WT and IL-17- mice during the time course. In vivo blockade of IFN-γ and IL-4 resulted in exacerbation of EAU at later phases with augmented IL-17 production. Taken together, our data demonstrated that IL-17/Th17 participates in the late phases of EAU and also that Th1 and Th17 responses are differentially required for EAU.
AB - IL-17-producing CD4+ T cells, so called Th17 cells, constitute a newly identified inflammatogenic cell population, which is critically involved in some inflammatory diseases. To explore the role of Th17 cells in murine experimental autoimmune uveoretinitis (EAU), a model of human autoimmune uveitis where Th1 responses predominantly participate in the pathogenesis, IL-17- mice were immunized with interphotoreceptor retinoid-binding protein peptide 1-20 for disease induction. Funduscopic examination revealed that EAU was induced in IL-17- mice just like in wild-type (WT) mice at early phases of the disease. However, at later/maintenance phases, the severity was significantly reduced in IL-17- mice. Expression of IFN-γ and MCP-1 was comparable between WT and IL-17- mice during the time course. In vivo blockade of IFN-γ and IL-4 resulted in exacerbation of EAU at later phases with augmented IL-17 production. Taken together, our data demonstrated that IL-17/Th17 participates in the late phases of EAU and also that Th1 and Th17 responses are differentially required for EAU.
KW - Autoimmunity
KW - Cytokines
KW - Inflammation
KW - T1
KW - T17
UR - http://www.scopus.com/inward/record.url?scp=39049129395&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=39049129395&partnerID=8YFLogxK
U2 - 10.1093/intimm/dxm135
DO - 10.1093/intimm/dxm135
M3 - Article
C2 - 18156624
AN - SCOPUS:39049129395
VL - 20
SP - 209
EP - 214
JO - International Immunology
JF - International Immunology
SN - 0953-8178
IS - 2
ER -