Differential roles for IFN-γ and IL-17 in experimental autoimmune uveoretinitis

Takeru Yoshimura, Koh Hei Sonoda, Yoshiyuki Miyazaki, Yoichiro Iwakura, Tatsuro Ishibashi, Akihiko Yoshimura, Hiroki Yoshida

Research output: Contribution to journalArticle

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Abstract

IL-17-producing CD4+ T cells, so called Th17 cells, constitute a newly identified inflammatogenic cell population, which is critically involved in some inflammatory diseases. To explore the role of Th17 cells in murine experimental autoimmune uveoretinitis (EAU), a model of human autoimmune uveitis where Th1 responses predominantly participate in the pathogenesis, IL-17- mice were immunized with interphotoreceptor retinoid-binding protein peptide 1-20 for disease induction. Funduscopic examination revealed that EAU was induced in IL-17- mice just like in wild-type (WT) mice at early phases of the disease. However, at later/maintenance phases, the severity was significantly reduced in IL-17- mice. Expression of IFN-γ and MCP-1 was comparable between WT and IL-17- mice during the time course. In vivo blockade of IFN-γ and IL-4 resulted in exacerbation of EAU at later phases with augmented IL-17 production. Taken together, our data demonstrated that IL-17/Th17 participates in the late phases of EAU and also that Th1 and Th17 responses are differentially required for EAU.

Original languageEnglish
Pages (from-to)209-214
Number of pages6
JournalInternational Immunology
Volume20
Issue number2
DOIs
Publication statusPublished - 2008 Feb
Externally publishedYes

Fingerprint

Interleukin-17
Th17 Cells
Uveitis
Interleukin-4
Maintenance
T-Lymphocytes
Peptides
Population

Keywords

  • Autoimmunity
  • Cytokines
  • Inflammation
  • T1
  • T17

ASJC Scopus subject areas

  • Immunology

Cite this

Yoshimura, T., Sonoda, K. H., Miyazaki, Y., Iwakura, Y., Ishibashi, T., Yoshimura, A., & Yoshida, H. (2008). Differential roles for IFN-γ and IL-17 in experimental autoimmune uveoretinitis. International Immunology, 20(2), 209-214. https://doi.org/10.1093/intimm/dxm135

Differential roles for IFN-γ and IL-17 in experimental autoimmune uveoretinitis. / Yoshimura, Takeru; Sonoda, Koh Hei; Miyazaki, Yoshiyuki; Iwakura, Yoichiro; Ishibashi, Tatsuro; Yoshimura, Akihiko; Yoshida, Hiroki.

In: International Immunology, Vol. 20, No. 2, 02.2008, p. 209-214.

Research output: Contribution to journalArticle

Yoshimura, T, Sonoda, KH, Miyazaki, Y, Iwakura, Y, Ishibashi, T, Yoshimura, A & Yoshida, H 2008, 'Differential roles for IFN-γ and IL-17 in experimental autoimmune uveoretinitis', International Immunology, vol. 20, no. 2, pp. 209-214. https://doi.org/10.1093/intimm/dxm135
Yoshimura, Takeru ; Sonoda, Koh Hei ; Miyazaki, Yoshiyuki ; Iwakura, Yoichiro ; Ishibashi, Tatsuro ; Yoshimura, Akihiko ; Yoshida, Hiroki. / Differential roles for IFN-γ and IL-17 in experimental autoimmune uveoretinitis. In: International Immunology. 2008 ; Vol. 20, No. 2. pp. 209-214.
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