Abstract
IL-17-producing CD4+ T cells, so called Th17 cells, constitute a newly identified inflammatogenic cell population, which is critically involved in some inflammatory diseases. To explore the role of Th17 cells in murine experimental autoimmune uveoretinitis (EAU), a model of human autoimmune uveitis where Th1 responses predominantly participate in the pathogenesis, IL-17- mice were immunized with interphotoreceptor retinoid-binding protein peptide 1-20 for disease induction. Funduscopic examination revealed that EAU was induced in IL-17- mice just like in wild-type (WT) mice at early phases of the disease. However, at later/maintenance phases, the severity was significantly reduced in IL-17- mice. Expression of IFN-γ and MCP-1 was comparable between WT and IL-17- mice during the time course. In vivo blockade of IFN-γ and IL-4 resulted in exacerbation of EAU at later phases with augmented IL-17 production. Taken together, our data demonstrated that IL-17/Th17 participates in the late phases of EAU and also that Th1 and Th17 responses are differentially required for EAU.
Original language | English |
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Pages (from-to) | 209-214 |
Number of pages | 6 |
Journal | International immunology |
Volume | 20 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2008 Feb |
Externally published | Yes |
Keywords
- Autoimmunity
- Cytokines
- Inflammation
- T1
- T17
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology