Differential roles for IFN-γ and IL-17 in experimental autoimmune uveoretinitis

Takeru Yoshimura, Koh Hei Sonoda, Yoshiyuki Miyazaki, Yoichiro Iwakura, Tatsuro Ishibashi, Akihiko Yoshimura, Hiroki Yoshida

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96 Citations (Scopus)

Abstract

IL-17-producing CD4+ T cells, so called Th17 cells, constitute a newly identified inflammatogenic cell population, which is critically involved in some inflammatory diseases. To explore the role of Th17 cells in murine experimental autoimmune uveoretinitis (EAU), a model of human autoimmune uveitis where Th1 responses predominantly participate in the pathogenesis, IL-17- mice were immunized with interphotoreceptor retinoid-binding protein peptide 1-20 for disease induction. Funduscopic examination revealed that EAU was induced in IL-17- mice just like in wild-type (WT) mice at early phases of the disease. However, at later/maintenance phases, the severity was significantly reduced in IL-17- mice. Expression of IFN-γ and MCP-1 was comparable between WT and IL-17- mice during the time course. In vivo blockade of IFN-γ and IL-4 resulted in exacerbation of EAU at later phases with augmented IL-17 production. Taken together, our data demonstrated that IL-17/Th17 participates in the late phases of EAU and also that Th1 and Th17 responses are differentially required for EAU.

Original languageEnglish
Pages (from-to)209-214
Number of pages6
JournalInternational immunology
Volume20
Issue number2
DOIs
Publication statusPublished - 2008 Feb

Keywords

  • Autoimmunity
  • Cytokines
  • Inflammation
  • T1
  • T17

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Yoshimura, T., Sonoda, K. H., Miyazaki, Y., Iwakura, Y., Ishibashi, T., Yoshimura, A., & Yoshida, H. (2008). Differential roles for IFN-γ and IL-17 in experimental autoimmune uveoretinitis. International immunology, 20(2), 209-214. https://doi.org/10.1093/intimm/dxm135