@article{ce1bf01705a24239b0caff4ecbcde8be,
title = "Differing impact of phosphoglycerate mutase 1-deficiency on brown and white adipose tissue",
abstract = "Brown adipose tissue (BAT) is a metabolically active organ that contributes to the thermogenic response to cold exposure. In addition, other thermogenic cells termed beige adipocytes are generated in white adipose tissue (WAT) by cold exposure. Although activation of brown/beige adipose tissue is associated with mobilization of both glucose and lipids, few studies have focused on the role of glycolytic enzymes in regulating adipose tissue function. We generated mouse models with specific deletion of the glycolytic enzyme phosphoglycerate mutase 1 (PGAM1) from adipose tissue. Deletion of Pgam1 from both BAT and WAT promoted whitening of BAT with beiging of visceral WAT, whereas deletion of Pgam1 from BAT alone led to whitening of BAT without beiging of WAT. Our results demonstrate a potential role of glycolytic enzymes in beiging of visceral WAT and suggest that PGAM1 would be a novel therapeutic target in obesity and diabetes.",
keywords = "Molecular biology, Molecular physiology, Physiology",
author = "Yohko Yoshida and Ippei Shimizu and Hsiao, {Yung Ting} and Masayoshi Suda and Goro Katsuumi and Masahide Seki and Yutaka Suzuki and Shujiro Okuda and Tomoyoshi Soga and Tohru Minamino",
note = "Funding Information: This work was supported by a Grant-in-Aid for Scientific Research (A) ( 20H00533 ) from MEXT , AMED under Grant Number JP20ek0210114 , and AMED-CREST under Grant Number JP20gm1110012 , and Moonshot Research and Development Program ( 21zf0127003s0201 ), MEXT Supported Program for the Scleroderma Research Foundation at Private Universities Japan , Private University Research Branding Project, and Leading Initiative for Excellent Young Researchers, and grants from the Science Research Promotion Fund, the Takeda Medical Research Foundation , the Vehicle Racing Commemorative Foundation , Ono Medical Research Foundation , and the Suzuken Memorial Foundation (to T.M.) as well as by a Grant-in-Aid for Scientific Research (C) (JSPS KAKENHI Grant Number 19K08974 ), Sakakibara Memorial Research Grant from The Japan Research Promotion Society for Cardiovascular Diseases, Astellas Foundation for Research on Metabolic Disorders, Japan Diabetes Foundation , TERUMO Life Science Foundation , Kanae Foundation (to Y.Y.) and by a grant from Bourbon (to T.M., I.S., and Y.Y.). Publisher Copyright: {\textcopyright} 2022 The Author(s)",
year = "2022",
month = may,
day = "20",
doi = "10.1016/j.isci.2022.104268",
language = "English",
volume = "25",
journal = "iScience",
issn = "2589-0042",
publisher = "Elsevier Inc.",
number = "5",
}
