Diffuse lamellar keratitis and flap margin epithelial healing after laser in situ keratomileusis

Naoko Asano-Kato, Ikuko Toda, Tomoko Tsuruya, Yoji Takano, Kazuo Tsubota

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

PURPOSE: To evaluate whether wound healing of the corneal epithelium at the flap margin influences development of diffuse lamellar keratitis (DLK) after laser in situ keratomileusis (LASIK). METHODS: We examined prospectively 1928 eyes of 994 patients after LASIK. Condition of wound healing at the flap margin 1 day after LASIK was graded as gutter score from 0 to 3, according to the extent of fluorescein staining. Existence of DLK, gutter score, and the location of DLK and gutter were evaluated. RESULTS: Sixty-eight eyes (3.5%) developed DLK. The average gutter score was significantly higher in patients with DLK compared to those without DLK (P<.001). The location of DLK was identical to the location of gutter in 44 eyes (77.2%). CONCLUSION: Disruption of integrity of the epithelial barrier function at the flap margin was associcated with diffuse lamellar keratitis after laser in situ keratomileusis.

Original languageEnglish
Pages (from-to)30-33
Number of pages4
JournalJournal of Refractive Surgery
Volume19
Issue number1
Publication statusPublished - 2003 Jan
Externally publishedYes

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Laser In Situ Keratomileusis
Keratitis
Wound Healing
Corneal Epithelium
Fluorescein
Staining and Labeling

ASJC Scopus subject areas

  • Ophthalmology

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Diffuse lamellar keratitis and flap margin epithelial healing after laser in situ keratomileusis. / Asano-Kato, Naoko; Toda, Ikuko; Tsuruya, Tomoko; Takano, Yoji; Tsubota, Kazuo.

In: Journal of Refractive Surgery, Vol. 19, No. 1, 01.2003, p. 30-33.

Research output: Contribution to journalArticle

Asano-Kato, Naoko ; Toda, Ikuko ; Tsuruya, Tomoko ; Takano, Yoji ; Tsubota, Kazuo. / Diffuse lamellar keratitis and flap margin epithelial healing after laser in situ keratomileusis. In: Journal of Refractive Surgery. 2003 ; Vol. 19, No. 1. pp. 30-33.
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