Diffuse lamellar keratitis and flap margin epithelial healing after laser in situ keratomileusis

Naoko Asano-Kato; Ikuko Toda; Tomoko Tsuruya; Yoji Takano; Kazuo Tsubota

Diffuse lamellar keratitis and flap margin epithelial healing after laser in situ keratomileusis

Naoko Asano-Kato, Ikuko Toda, Tomoko Tsuruya, Yoji Takano, Kazuo Tsubota

Research output: Contribution to journal › Article › peer-review

Abstract

PURPOSE: To evaluate whether wound healing of the corneal epithelium at the flap margin influences development of diffuse lamellar keratitis (DLK) after laser in situ keratomileusis (LASIK). METHODS: We examined prospectively 1928 eyes of 994 patients after LASIK. Condition of wound healing at the flap margin 1 day after LASIK was graded as gutter score from 0 to 3, according to the extent of fluorescein staining. Existence of DLK, gutter score, and the location of DLK and gutter were evaluated. RESULTS: Sixty-eight eyes (3.5%) developed DLK. The average gutter score was significantly higher in patients with DLK compared to those without DLK (P<.001). The location of DLK was identical to the location of gutter in 44 eyes (77.2%). CONCLUSION: Disruption of integrity of the epithelial barrier function at the flap margin was associcated with diffuse lamellar keratitis after laser in situ keratomileusis.

Original language	English
Pages (from-to)	30-33
Number of pages	4
Journal	Journal of Refractive Surgery
Volume	19
Issue number	1
Publication status	Published - 2003 Jan 1
Externally published	Yes

ASJC Scopus subject areas

Surgery
Ophthalmology

Fingerprint Dive into the research topics of 'Diffuse lamellar keratitis and flap margin epithelial healing after laser in situ keratomileusis'. Together they form a unique fingerprint.

Cite this

@article{a9ff755a9a3344adaafb3712031cee8a,

title = "Diffuse lamellar keratitis and flap margin epithelial healing after laser in situ keratomileusis",

abstract = "PURPOSE: To evaluate whether wound healing of the corneal epithelium at the flap margin influences development of diffuse lamellar keratitis (DLK) after laser in situ keratomileusis (LASIK). METHODS: We examined prospectively 1928 eyes of 994 patients after LASIK. Condition of wound healing at the flap margin 1 day after LASIK was graded as gutter score from 0 to 3, according to the extent of fluorescein staining. Existence of DLK, gutter score, and the location of DLK and gutter were evaluated. RESULTS: Sixty-eight eyes (3.5%) developed DLK. The average gutter score was significantly higher in patients with DLK compared to those without DLK (P<.001). The location of DLK was identical to the location of gutter in 44 eyes (77.2%). CONCLUSION: Disruption of integrity of the epithelial barrier function at the flap margin was associcated with diffuse lamellar keratitis after laser in situ keratomileusis.",

author = "Naoko Asano-Kato and Ikuko Toda and Tomoko Tsuruya and Yoji Takano and Kazuo Tsubota",

year = "2003",

month = jan,

day = "1",

language = "English",

volume = "19",

pages = "30--33",

journal = "Journal of Refractive Surgery",

issn = "0883-0444",

publisher = "Slack Incorporated",

number = "1",

}

TY - JOUR

T1 - Diffuse lamellar keratitis and flap margin epithelial healing after laser in situ keratomileusis

AU - Asano-Kato, Naoko

AU - Toda, Ikuko

AU - Tsuruya, Tomoko

AU - Takano, Yoji

AU - Tsubota, Kazuo

PY - 2003/1/1

Y1 - 2003/1/1

N2 - PURPOSE: To evaluate whether wound healing of the corneal epithelium at the flap margin influences development of diffuse lamellar keratitis (DLK) after laser in situ keratomileusis (LASIK). METHODS: We examined prospectively 1928 eyes of 994 patients after LASIK. Condition of wound healing at the flap margin 1 day after LASIK was graded as gutter score from 0 to 3, according to the extent of fluorescein staining. Existence of DLK, gutter score, and the location of DLK and gutter were evaluated. RESULTS: Sixty-eight eyes (3.5%) developed DLK. The average gutter score was significantly higher in patients with DLK compared to those without DLK (P<.001). The location of DLK was identical to the location of gutter in 44 eyes (77.2%). CONCLUSION: Disruption of integrity of the epithelial barrier function at the flap margin was associcated with diffuse lamellar keratitis after laser in situ keratomileusis.

AB - PURPOSE: To evaluate whether wound healing of the corneal epithelium at the flap margin influences development of diffuse lamellar keratitis (DLK) after laser in situ keratomileusis (LASIK). METHODS: We examined prospectively 1928 eyes of 994 patients after LASIK. Condition of wound healing at the flap margin 1 day after LASIK was graded as gutter score from 0 to 3, according to the extent of fluorescein staining. Existence of DLK, gutter score, and the location of DLK and gutter were evaluated. RESULTS: Sixty-eight eyes (3.5%) developed DLK. The average gutter score was significantly higher in patients with DLK compared to those without DLK (P<.001). The location of DLK was identical to the location of gutter in 44 eyes (77.2%). CONCLUSION: Disruption of integrity of the epithelial barrier function at the flap margin was associcated with diffuse lamellar keratitis after laser in situ keratomileusis.

UR - http://www.scopus.com/inward/record.url?scp=0037239644&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037239644&partnerID=8YFLogxK

M3 - Article

C2 - 12553602

AN - SCOPUS:0037239644

VL - 19

SP - 30

EP - 33

JO - Journal of Refractive Surgery

JF - Journal of Refractive Surgery

SN - 0883-0444

IS - 1

ER -