Diffuse lamellar keratitis and flap margin epithelial healing after laser in situ keratomileusis

Naoko Asano-Kato, Ikuko Toda, Tomoko Tsuruya, Yoji Takano, Kazuo Tsubota

Research output: Contribution to journalArticle

8 Citations (Scopus)


PURPOSE: To evaluate whether wound healing of the corneal epithelium at the flap margin influences development of diffuse lamellar keratitis (DLK) after laser in situ keratomileusis (LASIK). METHODS: We examined prospectively 1928 eyes of 994 patients after LASIK. Condition of wound healing at the flap margin 1 day after LASIK was graded as gutter score from 0 to 3, according to the extent of fluorescein staining. Existence of DLK, gutter score, and the location of DLK and gutter were evaluated. RESULTS: Sixty-eight eyes (3.5%) developed DLK. The average gutter score was significantly higher in patients with DLK compared to those without DLK (P<.001). The location of DLK was identical to the location of gutter in 44 eyes (77.2%). CONCLUSION: Disruption of integrity of the epithelial barrier function at the flap margin was associcated with diffuse lamellar keratitis after laser in situ keratomileusis.

Original languageEnglish
Pages (from-to)30-33
Number of pages4
JournalJournal of Refractive Surgery
Issue number1
Publication statusPublished - 2003 Jan
Externally publishedYes


ASJC Scopus subject areas

  • Ophthalmology

Cite this