Diffuse lamellar keratitis and flap margin epithelial healing after laser in situ keratomileusis

Naoko Asano-Kato; Ikuko Toda; Tomoko Tsuruya; Yoji Takano; Kazuo Tsubota

Diffuse lamellar keratitis and flap margin epithelial healing after laser in situ keratomileusis

Naoko Asano-Kato, Ikuko Toda, Tomoko Tsuruya, Yoji Takano, Kazuo Tsubota

Research output: Contribution to journal › Article

Abstract

PURPOSE: To evaluate whether wound healing of the corneal epithelium at the flap margin influences development of diffuse lamellar keratitis (DLK) after laser in situ keratomileusis (LASIK). METHODS: We examined prospectively 1928 eyes of 994 patients after LASIK. Condition of wound healing at the flap margin 1 day after LASIK was graded as gutter score from 0 to 3, according to the extent of fluorescein staining. Existence of DLK, gutter score, and the location of DLK and gutter were evaluated. RESULTS: Sixty-eight eyes (3.5%) developed DLK. The average gutter score was significantly higher in patients with DLK compared to those without DLK (P<.001). The location of DLK was identical to the location of gutter in 44 eyes (77.2%). CONCLUSION: Disruption of integrity of the epithelial barrier function at the flap margin was associcated with diffuse lamellar keratitis after laser in situ keratomileusis.

Original language	English
Pages (from-to)	30-33
Number of pages	4
Journal	Journal of Refractive Surgery
Volume	19
Issue number	1
Publication status	Published - 2003 Jan 1
Externally published	Yes

ASJC Scopus subject areas

Surgery
Ophthalmology

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Asano-Kato, N., Toda, I., Tsuruya, T., Takano, Y., & Tsubota, K. (2003). Diffuse lamellar keratitis and flap margin epithelial healing after laser in situ keratomileusis. Journal of Refractive Surgery, 19(1), 30-33.

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abstract = "PURPOSE: To evaluate whether wound healing of the corneal epithelium at the flap margin influences development of diffuse lamellar keratitis (DLK) after laser in situ keratomileusis (LASIK). METHODS: We examined prospectively 1928 eyes of 994 patients after LASIK. Condition of wound healing at the flap margin 1 day after LASIK was graded as gutter score from 0 to 3, according to the extent of fluorescein staining. Existence of DLK, gutter score, and the location of DLK and gutter were evaluated. RESULTS: Sixty-eight eyes (3.5%) developed DLK. The average gutter score was significantly higher in patients with DLK compared to those without DLK (P<.001). The location of DLK was identical to the location of gutter in 44 eyes (77.2%). CONCLUSION: Disruption of integrity of the epithelial barrier function at the flap margin was associcated with diffuse lamellar keratitis after laser in situ keratomileusis.",

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AU - Asano-Kato, Naoko

AU - Toda, Ikuko

AU - Tsuruya, Tomoko

AU - Takano, Yoji

AU - Tsubota, Kazuo

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N2 - PURPOSE: To evaluate whether wound healing of the corneal epithelium at the flap margin influences development of diffuse lamellar keratitis (DLK) after laser in situ keratomileusis (LASIK). METHODS: We examined prospectively 1928 eyes of 994 patients after LASIK. Condition of wound healing at the flap margin 1 day after LASIK was graded as gutter score from 0 to 3, according to the extent of fluorescein staining. Existence of DLK, gutter score, and the location of DLK and gutter were evaluated. RESULTS: Sixty-eight eyes (3.5%) developed DLK. The average gutter score was significantly higher in patients with DLK compared to those without DLK (P<.001). The location of DLK was identical to the location of gutter in 44 eyes (77.2%). CONCLUSION: Disruption of integrity of the epithelial barrier function at the flap margin was associcated with diffuse lamellar keratitis after laser in situ keratomileusis.

AB - PURPOSE: To evaluate whether wound healing of the corneal epithelium at the flap margin influences development of diffuse lamellar keratitis (DLK) after laser in situ keratomileusis (LASIK). METHODS: We examined prospectively 1928 eyes of 994 patients after LASIK. Condition of wound healing at the flap margin 1 day after LASIK was graded as gutter score from 0 to 3, according to the extent of fluorescein staining. Existence of DLK, gutter score, and the location of DLK and gutter were evaluated. RESULTS: Sixty-eight eyes (3.5%) developed DLK. The average gutter score was significantly higher in patients with DLK compared to those without DLK (P<.001). The location of DLK was identical to the location of gutter in 44 eyes (77.2%). CONCLUSION: Disruption of integrity of the epithelial barrier function at the flap margin was associcated with diffuse lamellar keratitis after laser in situ keratomileusis.

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