Diffusion-weighted MRI as an adjunct to mammography in women under 50 years of age

An initial study

Toshiki Kazama, Yoshifumi Kuroki, Mari Kikuchi, Yasunori Sato, Takeshi Nagashima, Yukimasa Miyazawa, Masahiro Sakakibara, Katsuhiko Kaneoya, Yumi Makimoto, Hideyuki Hashimoto, Ken Motoori, Hideyuki Takano

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Purpose: To evaluate diffusion-weighted magnetic resonance (DW) imaging as an adjunct to mammography for the detection of small invasive breast cancer. Materials and Methods: Institutional review board standards were followed for this retrospective study. We performed both breast DW imaging and mammography on 25 women under 50 years of age with pathologically proven T1 breast cancer and on 21 healthy women under 50 years of age. Four offsite radiologists blind to the clinical information independently interpreted the mammograms and DW images and then classified their confidence level regarding the presence of breast cancer. The composite area under receiver operating characteristic curve (AUC), of mammography alone, DW imaging alone, and the combination of DW imaging and mammography (DWI/Cal) were calculated. Results: The AUC of composite ROC curves of mammography, DW imaging, DWI/Cal combination, was 0.79 (95% CI, 0.72-0.87), 0.86 (95% CI, 0.84-0.87), and 0.96 (95% CI, 0.92-1.00), respectively. Conclusion: DW imaging may be a useful adjunct to mammography in the detection of small invasive breast cancer in women under 50 years of age.

Original languageEnglish
Pages (from-to)139-144
Number of pages6
JournalJournal of Magnetic Resonance Imaging
Volume36
Issue number1
DOIs
Publication statusPublished - 2012 Jul 1
Externally publishedYes

Fingerprint

Diffusion Magnetic Resonance Imaging
Mammography
Breast Neoplasms
ROC Curve
Area Under Curve
Research Ethics Committees
Breast
Retrospective Studies
Magnetic Resonance Imaging

Keywords

  • breast
  • diffusion-weighted image
  • mammography
  • MRI

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Kazama, T., Kuroki, Y., Kikuchi, M., Sato, Y., Nagashima, T., Miyazawa, Y., ... Takano, H. (2012). Diffusion-weighted MRI as an adjunct to mammography in women under 50 years of age: An initial study. Journal of Magnetic Resonance Imaging, 36(1), 139-144. https://doi.org/10.1002/jmri.23626

Diffusion-weighted MRI as an adjunct to mammography in women under 50 years of age : An initial study. / Kazama, Toshiki; Kuroki, Yoshifumi; Kikuchi, Mari; Sato, Yasunori; Nagashima, Takeshi; Miyazawa, Yukimasa; Sakakibara, Masahiro; Kaneoya, Katsuhiko; Makimoto, Yumi; Hashimoto, Hideyuki; Motoori, Ken; Takano, Hideyuki.

In: Journal of Magnetic Resonance Imaging, Vol. 36, No. 1, 01.07.2012, p. 139-144.

Research output: Contribution to journalArticle

Kazama, T, Kuroki, Y, Kikuchi, M, Sato, Y, Nagashima, T, Miyazawa, Y, Sakakibara, M, Kaneoya, K, Makimoto, Y, Hashimoto, H, Motoori, K & Takano, H 2012, 'Diffusion-weighted MRI as an adjunct to mammography in women under 50 years of age: An initial study', Journal of Magnetic Resonance Imaging, vol. 36, no. 1, pp. 139-144. https://doi.org/10.1002/jmri.23626
Kazama, Toshiki ; Kuroki, Yoshifumi ; Kikuchi, Mari ; Sato, Yasunori ; Nagashima, Takeshi ; Miyazawa, Yukimasa ; Sakakibara, Masahiro ; Kaneoya, Katsuhiko ; Makimoto, Yumi ; Hashimoto, Hideyuki ; Motoori, Ken ; Takano, Hideyuki. / Diffusion-weighted MRI as an adjunct to mammography in women under 50 years of age : An initial study. In: Journal of Magnetic Resonance Imaging. 2012 ; Vol. 36, No. 1. pp. 139-144.
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