Digital gene atlas of neonate common marmoset brain

Tomomi Shimogori, Ayumi Abe, Yasuhiro Go, Tsutomu Hashikawa, Noriyuki Kishi, Satomi S. Kikuchi, Yoshiaki Kita, Kimie Niimi, Hirozumi Nishibe, Misako Okuno, Kanako Saga, Miyano Sakurai, Masae Sato, Tsuna Serizawa, Sachie Suzuki, Eiki Takahashi, Mami Tanaka, Shoji Tatsumoto, Mitsuhiro Toki, Mami UYan Wang, Karl J. Windak, Haruhiko Yamagishi, Keiko Yamashita, Tomoko Yoda, Aya C. Yoshida, Chihiro Yoshida, Takuro Yoshimoto, Hideyuki Okano

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Interest in the common marmoset (Callithrix jacchus) as a primate model animal has grown recently, in part due to the successful demonstration of transgenic marmosets. However, there is some debate as to the suitability of marmosets, compared to more widely used animal models, such as the macaque monkey and mouse. Especially, the usage of marmoset for animal models of human cognition and mental disorders, is still yet to be fully explored. To examine the prospects of the marmoset model for neuroscience research, the Marmoset Gene Atlas (https://gene-atlas.bminds.brain.riken.jp/) provides a whole brain gene expression atlas in the common marmoset. We employ in situ hybridization (ISH) to systematically analyze gene expression in neonate marmoset brains, which allows us to compare expression with other model animals such as mouse. We anticipate that these data will provide sufficient information to develop tools that enable us to reveal marmoset brain structure, function, cellular and molecular organization for primate brain research.

Original languageEnglish
JournalNeuroscience Research
DOIs
Publication statusAccepted/In press - 2017

Fingerprint

Callithrix
Atlases
Brain
Genes
Animal Models
Primates
Cognition Disorders
Gene Expression
Macaca
Cellular Structures
Neurosciences
Molecular Structure
Research
Mental Disorders
Haplorhini
In Situ Hybridization

Keywords

  • Common marmoset
  • Comparative analysis
  • Digital atlas
  • High throughput ISH analysis
  • Mental disorder

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Shimogori, T., Abe, A., Go, Y., Hashikawa, T., Kishi, N., Kikuchi, S. S., ... Okano, H. (Accepted/In press). Digital gene atlas of neonate common marmoset brain. Neuroscience Research. https://doi.org/10.1016/j.neures.2017.10.009

Digital gene atlas of neonate common marmoset brain. / Shimogori, Tomomi; Abe, Ayumi; Go, Yasuhiro; Hashikawa, Tsutomu; Kishi, Noriyuki; Kikuchi, Satomi S.; Kita, Yoshiaki; Niimi, Kimie; Nishibe, Hirozumi; Okuno, Misako; Saga, Kanako; Sakurai, Miyano; Sato, Masae; Serizawa, Tsuna; Suzuki, Sachie; Takahashi, Eiki; Tanaka, Mami; Tatsumoto, Shoji; Toki, Mitsuhiro; U, Mami; Wang, Yan; Windak, Karl J.; Yamagishi, Haruhiko; Yamashita, Keiko; Yoda, Tomoko; Yoshida, Aya C.; Yoshida, Chihiro; Yoshimoto, Takuro; Okano, Hideyuki.

In: Neuroscience Research, 2017.

Research output: Contribution to journalArticle

Shimogori, T, Abe, A, Go, Y, Hashikawa, T, Kishi, N, Kikuchi, SS, Kita, Y, Niimi, K, Nishibe, H, Okuno, M, Saga, K, Sakurai, M, Sato, M, Serizawa, T, Suzuki, S, Takahashi, E, Tanaka, M, Tatsumoto, S, Toki, M, U, M, Wang, Y, Windak, KJ, Yamagishi, H, Yamashita, K, Yoda, T, Yoshida, AC, Yoshida, C, Yoshimoto, T & Okano, H 2017, 'Digital gene atlas of neonate common marmoset brain', Neuroscience Research. https://doi.org/10.1016/j.neures.2017.10.009
Shimogori, Tomomi ; Abe, Ayumi ; Go, Yasuhiro ; Hashikawa, Tsutomu ; Kishi, Noriyuki ; Kikuchi, Satomi S. ; Kita, Yoshiaki ; Niimi, Kimie ; Nishibe, Hirozumi ; Okuno, Misako ; Saga, Kanako ; Sakurai, Miyano ; Sato, Masae ; Serizawa, Tsuna ; Suzuki, Sachie ; Takahashi, Eiki ; Tanaka, Mami ; Tatsumoto, Shoji ; Toki, Mitsuhiro ; U, Mami ; Wang, Yan ; Windak, Karl J. ; Yamagishi, Haruhiko ; Yamashita, Keiko ; Yoda, Tomoko ; Yoshida, Aya C. ; Yoshida, Chihiro ; Yoshimoto, Takuro ; Okano, Hideyuki. / Digital gene atlas of neonate common marmoset brain. In: Neuroscience Research. 2017.
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